Neurobehavioural Activity In Albino Wistar Rats In The Open Field Maze Following Long Term Tobacco Diet Ingestion

Mesembe, OE; Sa, Biswanath; Ekong, Moses B.; Ekeoma, AO

doi:10.5580/2405

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…The occurrence and the number of backward movements (Table 4 ) appeared to be random with no pattern between the treatments and days of LA analysis. Rearing (standing on hindlimbs without support) was not observed but the animals could stand on hindlimbs with forepaws placed on the cage wall for support, a feature referred to as walling (Mesembe et al 2012 ). The number of completed walling bouts did not significantly differ between all the treatment groups at any recording time point, except on day 1 (ANOVA: F (3, 31) = 4.3, p = 0.01), where walling bouts in the untreated controls were significantly higher than in LPS5 group (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In the open field, away from any support, these animals did not lift their forelimbs off the ground/floor to stand on hind limbs, a feature referred to as rearing. However, the animals did stand on rear limbs with the forepaws placed against the cage wall, a feature referred to as “walling” (Mesembe et al 2012 ). This could be due to the design of the locomotor apparatus of this animal that doesn’t allow lifting of the forelimbs without support.…”

Section: Discussionmentioning

confidence: 99%

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Bodyweight, locomotion, and behavioral responses of the naked mole rat (Heterocephalus glaber) to lipopolysaccharide administration

et al. 2022

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The naked mole rat has unique biologic characteristics that include atypical inflammatory responses. Lipopolysaccharide induces inflammation which triggers brain centers controlling feeding, and behavior to result in “sick animal behavior”. We characterized the bodyweight, locomotor, and other behavioral responses of this rodent to lipopolysaccharide administration. Lipopolysaccharide caused weight losses, which were not prevented by TAK 242. In the open field test, lipopolysaccharide did not depress locomotion, while urination, defecation, and activity freezing were rare. The animals exhibited walling but not rearing and fast backward movements that were unaffected by lipopolysaccharide. Failure to depress locomotion suggests either a unique immunity-brain crosstalk or motor responses/centers that tolerate depressive effects of inflammation. The absence of activity freezing and rarity of urination and defecation suggests that novel environments or lipopolysaccharide do not induce anxiety, or that anxiety is expressed differently in the animal. The absence of rearing could be due to the design of the animal’s locomotor apparatus while fast backward movement could be a mechanism for quick escape from threats in the tunnels of their habitat. Our results elucidate the unique biology of this rodent, which elicits interest in the animal as a model for inflammatory research, although the findings require mechanistic corroborations.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bodyweight, locomotion, and behavioral responses of the naked mole rat (Heterocephalus glaber) to lipopolysaccharide administration

et al. 2022

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Effect of Sub-Lethal Doses of Smokeless Tobacco (Snuff) on Some Haemato-Rheological Parameters Using Albino Wistar Rats

Adias¹,

Ajugwo²,

Erhabor³

et al. 2014

AJMSM

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The tobacco plant (Nicotiana tabacum) has been used globally for several years as chewing tobacco, kreteck, dry snuff and in pipe. Snuff is a form of tobacco that is processed to fine grains and packaged either in cans or pouches. This study was carried out to investigate the effect of sub-lethal concentrations of orogastricallyadministered tobacco on some haematological and haemorrheological parameters of albino Wistar rats. Nineteen young albino Wistar rats with weights between 110-170 g were used for the study. The oral LD50 for the tobacco snuff concentration was determined as 10 mg per 200 g rat body weight. The control group A was given 1 ml of distilled water, while the experimental groups (B, C, D) were administered with tobacco snuff concentrations of 2.24 mg, 4.67 mg, and 6.77 mg per body weight respectively, through an oral route with the aid of orogastric tube for 14 days. Blood samples were collected under chloroform anaesthesia and analysed for haematocrit, haemoglobin concentration, white blood cell (WBC), platelet counts, whole blood viscosity, plasma viscosity and serum viscosity. WBC was significantly increased (p<0.05) in group D (13.43±4.26 x10 9

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Neurobehavioural Activity In Albino Wistar Rats In The Open Field Maze Following Long Term Tobacco Diet Ingestion

Cited by 2 publications

References 22 publications

Bodyweight, locomotion, and behavioral responses of the naked mole rat (Heterocephalus glaber) to lipopolysaccharide administration

Bodyweight, locomotion, and behavioral responses of the naked mole rat (Heterocephalus glaber) to lipopolysaccharide administration

Effect of Sub-Lethal Doses of Smokeless Tobacco (Snuff) on Some Haemato-Rheological Parameters Using Albino Wistar Rats

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