Neurobehavioral Techniques to Assess the Effects of Chemicals on the Nervous System

Tilson, Hugh A.; Mitchell, Clifford L.

doi:10.1146/annurev.pa.24.040184.002233

Cited by 55 publications

(14 citation statements)

References 58 publications

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“…Standard behavioral tests were selected to evaluate motor function in PBGD -/-mice (12). The rotorod test measures motor coordination and proprioceptive sensitivity.…”

Section: Methodsmentioning

confidence: 99%

Motor neuropathy in porphobilinogen deaminase–deficient mice imitates the peripheral neuropathy of human acute porphyria

Lindberg¹,

Martini²,

Baumgartner³

et al. 1999

J. Clin. Invest.

103

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“…Standard behavioral tests were selected to evaluate motor function in PBGD -/-mice (12). The rotorod test measures motor coordination and proprioceptive sensitivity.…”

Section: Methodsmentioning

confidence: 99%

Motor neuropathy in porphobilinogen deaminase–deficient mice imitates the peripheral neuropathy of human acute porphyria

Lindberg¹,

Martini²,

Baumgartner³

et al. 1999

J. Clin. Invest.

103

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“…Mindful of the guidelines for behavioral neurotoxicology testing set forth by the U.S. Environmental Protection Agency, the National Toxicology Program, and others (Off ice of Prevention, 1998aPrevention, , 1998bPryor, Uyeno, Tilson, & Mitchell, 1983;Reiter, 1978;Reiter & MacPhail, 1979;Tilson, 1987Tilson, , 1990Tilson & Mitchell, 1984;Tilson & Moser, 1992), three behavior paradigms targeting a variety of brain-behavior interactions were chosen for the pilot studies presented here: open-field activity, rotorod, and habituation of acoustic startle. Unlike the radial arm maze or most conditioning tasks, each of these tests requires a single, relatively short test session to be administered.…”

mentioning

confidence: 99%

Behavioral consequences of radiation exposure to simulated space radiation in the C57BL/6 mouse: Open field, rotorod, and acoustic startle

Pecaut

Haerich

Zuccarelli

et al. 2002

Cognitive, Affective, & Behavioral Neuroscience

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Two experiments were carried out to investigate the consequences of exposure to proton radiation, such as might occur for astronauts during space flight. C57BL/6 mice were exposed, either with or without 15-g/cm 2 aluminum shielding, to 0-, 3-, or 4-Gy proton irradiation mimicking features of a solar particle event. Irradiation produced transient direct deficits in open-field exploratory behavior and acoustic startle habituation. Rotorod performance at 18 rpm was impaired by exposure to proton radiation and was impaired at 26 rpm, but only for mice irradiated with shielding and at the 4-Gy dose. Long-term (>2 weeks) indirect deficits in open-field activity appeared as a result of impaired experiential encoding immediately following exposure. A 2-week recovery prior to testing decreased most of the direct effects of exposure, with only rotorod performance at 26 rpm being impaired. These results suggest that the performance deficits may have been mediated by radiation damage to hippocampal, cerebellar, and possibly, forebrain dopaminergic function.

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“…Deficits in learning and remembering are commonly reported symptoms of human exposure to a diverse range of industrial and agricultural chemicals (Anger & Johnson, 1985;Tilson & Mitchell, 1984). Because of the vast number of chemicals existing in the environment that have not been assessed for potential neurotoxic properties, a need exists for tests of chemical effects on the acquisition of behavioral control in laboratory animals.…”

mentioning

confidence: 99%

Effects of Scopolamine on Repeated Acquisition of Radial‐arm Maze Performance by Rats

Peele

Baron²

1988

J Exper Analysis Behavior

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Rats repeatedly acquired the performance of selecting only the four baited arms in an automated eight-arm radial maze, with the arms containing food pellets randomly assigned prior to each session. During each 14-trial (trial: obtain all four pellets) daily session, the number of errors (selecting nonbaited arms or repeating arm selections) showed a within-session decline, and choice accuracy for the first four arm selections showed a positive acceleration across trials for all rats. An index-ofcurvature statistic, calculated for total errors, was used to quantify both the within-and betweensession improvement of performance. Scopolamine (0.03 to 0.3 mg/kg, ip), but not methylscopolamine (0.3 mg/kg), reduced the accuracy of the first four selections of each trial and increased total withinsession errors for all rats. Session times also were increased by scopolamine. An examination of withinsession accuracy showed only slight signs of improvement at the higher dosages of scopolamine. The results indicate that behavior in transition states maintained by reinforcement contingencies in the radial maze is similar to that maintained by extended chained schedules, despite the fact that some of the stimuli controlling behavior in the maze are absent at the moment behavior is emitted.

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Neurobehavioral Techniques to Assess the Effects of Chemicals on the Nervous System

Cited by 55 publications

References 58 publications

Motor neuropathy in porphobilinogen deaminase–deficient mice imitates the peripheral neuropathy of human acute porphyria

Motor neuropathy in porphobilinogen deaminase–deficient mice imitates the peripheral neuropathy of human acute porphyria

Behavioral consequences of radiation exposure to simulated space radiation in the C57BL/6 mouse: Open field, rotorod, and acoustic startle

Effects of Scopolamine on Repeated Acquisition of Radial‐arm Maze Performance by Rats

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