Neurobehavioral Status and Health-Related Quality of Life in Newly Diagnosed High-Grade Glioma Patients

Klein, Martin; Taphoorn, Martin J.B.; Heimans, Jan J.; Ploeg, Henk M. van der; Vandertop, W. Peter; Smit, Egbert F.; Leenstra, Sieger; Tulleken, C. A. F.; Boogerd, Willem; Belderbos, J.; Cleijne, Wilmy; Aaronson, Neil K.

doi:10.1200/jco.2001.19.20.4037

Cited by 241 publications

(175 citation statements)

References 32 publications

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“…HGG patients experience the same level of HRQOL as those with other neurological diseases of the central and peripheral nervous system [34]. When comparing HGG patients with other cancer patients, such as those with lung cancer, similar quality of life results were found [20].…”

Section: Hrqol In Glioma Patientssupporting

confidence: 59%

“…As one would expect, the majority of newly diagnosed HGG patients have a significantly impaired level of HRQOL, compared with healthy controls [20,21]. Systematic pretreatment evaluation of HRQOL in clinical trials illustrates clearly that the disease itself has a major negative impact and that treatment may improve HRQOL [22][23][24].…”

Section: Hrqol In Glioma Patientsmentioning

confidence: 99%

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Review on Quality of Life Issues in Patients with Primary Brain Tumors

2010

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Health-related quality of life (HRQOL) has become an important outcome measure in clinical trials in primary brain tumor (i.e., glioma) patients, because they have an incurable disease. HRQOL is assessed using self-reported, validated questionnaires, addressing physical, psychological, emotional, and social issues. In addition to generic HRQOL instruments, disease-specific questionnaires have been developed, including for brain tumor patients. For the analysis and interpretation of HRQOL measurements, low compliance and missing data are methodological challenges. HRQOL in glioma patients may be negatively affected by the disease itself as well as by side effects of treatment. But treatment with surgery, radiotherapy, and chemotherapy may improve patient functioning and HRQOL, in addition to extending survival.Although HRQOL has prognostic significance in brain tumor patients, it is not superior to well-known clinical parameters, such as age and performance status. In clinical practice, assessing HRQOL may be helpful in the communication between doctor and patient and may facilitate treatment decisions. The Oncologist 2010;15:618 -626

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Section: Hrqol In Glioma Patientssupporting

confidence: 59%

Section: Hrqol In Glioma Patientsmentioning

confidence: 99%

Review on Quality of Life Issues in Patients with Primary Brain Tumors

2010

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“…6,7 After surgical resection, the standard of care for patients with newly diagnosed glioblastoma and a good Karnofsky performance score (≥70, on a scale of 0 to 100, with higher numbers indicating better functioning) is concurrent radiotherapy and temozolomide, followed by adjuvant temozolomide. [8][9][10][11] The prognosis remains poor; no further improvements in outcomes have been doc umented since the introduction of radiotherapy-temozolomide therapy in 2005.…”

mentioning

confidence: 99%

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

Chinot¹,

Wick²,

Mason³

et al. 2014

N Engl J Med

2,136

1,618

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Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. Medicine, http://dx.doi.org/10.1056/NEJMoa1308345 New England Journal ofAccess to the published version may require subscription. N.B. When citing this work, cite the original published paper. Permanent link to this version:http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-89503T h e ne w e ngl a nd jou r na l o f m e dicine n engl j med 370;8 nejm

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“…Una de las manifestaciones clínicas más frecuentes en estos pacientes son los défi-cits cognitivos, que se asocian a su vez a elevada morbilidad y a una negativa en su calidad de vida (3)(4)(5) , los que convierte a los tumores cerebrales en una de las principales patologías neurológicas con este tipo de sintomatología (6) . Sin embargo, los datos de prevalencia sobre los déficits cognitivos en pacientes con tumores cerebrales son muy dispersos en función de los diferentes estudios, oscilando los porcentajes entre el 12% y el 90%, durante todo el proceso de la enfermedad (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) . En lo que sí parece haber acuerdo en la literatura, es respecto a los dominios cognitivos que presentan mayor afectación en estos enfermos (16,(18)(19)(20)(21)(22)(23) , entre los que cabe destacar: -Atención: velocidad de procesamiento de la información y atención alternante.…”

Section: Introductionunclassified

Rehabilitación neuropsicológica en pacientes con tumores cerebrales

Cortés¹,

Crespo

2014

Psicooncología

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ResumenLos déficits cognitivos son uno de los sínto-mas más frecuentes en pacientes con tumores cerebrales, principalmente en atención, memoria y funciones ejecutivas. Estas alteraciones impactan de forma negativa en al calidad de vida de los pacientes y en su reincorporación a su funcionamiento diario. En los últi-mos años se están desarrollando programas de Rehabilitación Neuropsicológica en pacientes adultos con tumores cerebrales, con resultados positivos. Así, los autores recomiendas que las intervenciones incluyan técnicas de psico-educación, estrategias de recuperación de los diferentes procesos atencionales y de ejecutivos (planificación y organización), así como técni-cas compensatorias para la memoria. Los trabajos publicados hasta la fecha muestran mejoría inmediatamente después de la intervención en atención y memoria. Sin embargo, no existen datos del impacto de estos programas de Rehabilitación en el rendimiento de estos pacientes a medio y largo plazo (más de seis meses). Futuros estudios necesitan evaluar la eficacia de este tipo de intervención en pacientes mayores con tumores cerebrales, así como diferenciar los resultados en función del tipo de tumor y de los tratamientos oncológicos aplicados, ya que estas dos características pueden afectar de forma significativa a los datos obtenidos.Palabras clave: tumores cerebrales, pacientes adultos, Rehabilitación Neuropsicológica. The authors recommend that interventions include psychoeducation techniques, recovery strategies of different attentional and executive processes (planning and organization) and compensatory techniques for memory. The studies published to date show improvement immediately after surgery in attention and memory. However, there are not data exist on the impact of these programs on performance rehabilitation of these patients in the medium and long term (over six months). The future studies need to evaluate the effectiveness of this intervention in elderly patients with brain tumors, and the results differ depending on the type of tumor and cancer treatments applied, as these two features can significantly affect the data obtained.

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Neurobehavioral Status and Health-Related Quality of Life in Newly Diagnosed High-Grade Glioma Patients

Cited by 241 publications

References 32 publications

Review on Quality of Life Issues in Patients with Primary Brain Tumors

Review on Quality of Life Issues in Patients with Primary Brain Tumors

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

Rehabilitación neuropsicológica en pacientes con tumores cerebrales

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