Neurobehavioral functioning after cessation of manganese exposure: A follow‐up after 14 years

Abstract

Manganese exposure was associated with persistent deficits for certain neuromotor functions, cognitive flexibility, and adVerse mood states, while recovery occurred for other functions.

Neuromotor function in ship welders after cessation of manganese exposure

“…Numerous studies of workers exposed to Mn have revealed poorer performance and/or associations between performance and exposure in neuromotor tests evaluating motor speed, eye-hand coordination, manual dexterity, and rapid alternating movements (Bast-Pettersen et al 2004;Beuter et al 1994;Bouchard et al 2007;Bowler et al 2003Bowler et al , 2006Bowler et al , 2007Chang et al 2009;Chia et al 1993;Ellingsen et al 2008;Hochberg et al 1996;Hua and Huang 1991;Iregren 1990;Lucchini et al 1995Lucchini et al , 1997Lucchini et al , 1999Mergler et al 1994;Roels et al 1987Roels et al , 1992Roels et al , 1999Sjögren et al 1996;Wennberg et al 1991). Impairment in hand steadiness and alterations in tremor parameters are also common findings (Bast-Pettersen et al 2004;Bowler et al 2007;Chang et al 2009;Crump and Rousseau 1999;Hochberg et al 1996;Lucchini et al 1999;Mergler et al 1994;Roels et al 1987Roels et al , 1992Roels et al , 1999.…”

“…However, some studies are essentially negative (Gibbs et al 1999;Myers et al 2003a, b). It is still unclear whether some of these effects may persist even long after cessation of exposure (Beuter et al 1994;Bouchard et al 2007;Hochberg et al 1996;Roels et al 1999).…”

Health effects of manganese exposures for welders in Qingdao City, China

“…Although it is an element needed for proper bodily function, too much manganese may lead to significant neurologic disease, even death. No serious scientific questions have been raised regarding the effects of MN among manganese miners [2] and foundry workers [3,4] but there is some continuing controversy about the potential effects of MN from welding rods and its ability to cause disease among welders [5]. One of the difficulties in making this assessment has been the confusion about terminology.…”

Longitudinal and contemporaneous manganese exposure in apartheid-era South Africa: Implications for the past and future

“…Manganese affects human health at the acute level (manganism), and the chronic, sub-clinical level (He and Niu, 2004). Acute exposure is generally characterised by severe neurological disturbance and with Parkinson's like pathology (tremors, loss of coordination, motor skill deficits) whereas chronic exposure can result in milder motor skills deficits and mood disturbances (Bouchard et al, 2007;Bouchard et al, 2011;Bowler et al, 1999;Mergler et al, 1999;Roels et al, 2012). Manganese affects neurological development and the central nervous system by interfering with the function of the neurotransmitter dopamine (Aschner and Aschner, 1991;Butterworth et al, 1995;Normandin and Hazell, 2002;Verity, 1999).…”