Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice

Emission patterns and risk assessment of polybrominated diphenyl ethers and bromophenols in water and sediments from the Beijiang River, South China

“…However, both additive and reactive TBBPA can be released into the environment from products which has been frequently detected in air, water, sediments, soil and human tissues (Nakao et al, 2015;Ni and Zeng, 2013;Wang et al, 2015a;Xiong et al, 2015). Several studies have demonstrated the toxic properties of TBBPA, including endocrine-disrupting activity, immunotoxicity, and neurotoxicity (Decherf et al, 2010;Hendriks et al, 2014;Nakajima et al, 2009).…”

Rapid determination of tetrabromobisphenol A and its main derivatives in aqueous samples by ultrasound-dispersive liquid–liquid microextraction combined with high-performance liquid chromatography

“…Available evidence indicates that TBBPA and TBBPA-bis (allyl ether) (TBBPA-BAE) lead to potentially toxic endocrine-disruptor effects, immunotoxicity, and neurotoxicity, all because their structures resemble the thyroid hormone thyroxin (T4) and bisphenol A [5][6][7]. Other studies have shown that TBBPA can be debrominated under anaerobic and aerobic conditions [8,9] to yield bisphenol A, a widely used compound with a disruptive endocrine function [10].…”

Synergistic neurotoxicity of oxygen-glucose deprivation and tetrabromobisphenol A in vitro: role of oxidative stress

“…Experiments performed in vivo have shown that the acute exposure of adult mice to TBBPA results in its selective accumulation in the striatum, which is accompanied by significant behavioral effects [24]. There are also indications that TBBPA may act as a developmental neurotoxin [20], although there has been a lack of consistency in studies describing the neurodevelopmental effects of TBBPA [38].…”