Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review

Malone, Samantha G.; Shaykin, Jakob D.; Stairs, Dustin J.; Bardo, Michael T.

doi:10.1016/j.pbb.2022.173471

Cited by 10 publications

(5 citation statements)

References 117 publications

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“…The beneficial effects of EE are mediated by the brain's intrinsic ability to adapt to environmental changes through structural, biochemical, and functional alterations. More specifically, EE increases brain weight and enhances neurogenesis, synaptic plasticity, and dendritic growth (Malone et al., 2022; Manosso et al., 2022; Rostami et al., 2021). Furthermore, EE increases astrocyte proliferation after brain injury, as indicated by the number of hippocampal GFAP positive cells (Chen et al., 2017; Durán‐Carabali et al., 2019; Zhang et al., 2020) and alters astrocytic morphology, changes that are associated with synapse formation (Nilsson & Pekny, 2007; Viola et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Dandi,

Theotokis,

Petri

et al. 2023

Developmental Psychobiology

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This study aims at investigating whether environmental enrichment (EE) initiated in adolescence can alter chronic unpredictable stress (CUS)‐associated changes in astroglial and synaptic plasticity markers in male and female rats. To this end, we studied possible alterations in hippocampal glial fibrillary acidic protein (GFAP) and synaptophysin (SYN) in CUS rats previously housed in EE. Wistar rats on postnatal day (PND) 23 were housed for 10 weeks in standard housing (SH) or enriched conditions. On PND 66, animals were exposed to CUS for 4 weeks. SYN and GFAP expressions were evaluated in CA1 and CA3 subfields and dentate gyrus (DG). CUS reduced the expression of SYN in all hippocampal areas, whereas lower GFAP expression was evident only in CA1 and CA3. The reduced expression of SYN in DG and CA3 was evident to male SH/CUS rats, whereas the reduced GFAP expression in CA1 and CA3 was limited to SH/CUS females. EE housing increased the hippocampal expression of both markers and protected against CUS‐associated decreases. Our findings indicate that the decreases in the expression of SYN and GFAP following CUS are region and sex‐specific and underline the neuroprotective role of EE against these CUS‐associated changes.

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Section: Introductionmentioning

confidence: 99%

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Dandi,

Theotokis,

Petri

et al. 2023

Developmental Psychobiology

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“…[16] Studies have reported that peer group pressure, environment factors, parental background and unemployment contribute to drug abuse practices. [20][21][22][23] The findings from this study suggest that the percentage distribution of positive and negative behavioural perception can be ascribed to peer group, environment, parental background and unemployment, as a higher proportion agreed that these factors influence drug abuse. This agrees with the reports that these factors influence individuals' behavioural perceptions and attitudes.…”

Section: Discussionmentioning

confidence: 67%

A Community-Based Study of Behavioural Perception of Psychoactive Drug Abuse in Southern Nigeria

Ajuzie¹,

Martin²,

Onwuka

2023

Ann Health Res

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Background: Behavioural therapy is an effective intervention for drug abuse. Assessing the behavioural perception of drug abuse may reveal practices and focus points that require interventional sensitisation programs. Objective: To ascertain the pattern of behavioural perception of psychoactive drug abuse. Methods: This descriptive study was carried out between May and August 2022, among randomly selected residents of a community in Southern Nigeria using a structured questionnaire. Results: Out of a total of 120 participants, 41.7% agreed that drugs are necessary to maintain their status in the society, 46.7% agreed that drugs could be taken to promote social gathering effectively, 46.7% agreed that there is no wrong in taking drugs while 62.5% agreed that drugs could kill. Forty per cent agreed that drugs are necessary for validation agreements, while 22.5% agreed that drugs are meant for frustrated people. Over half (58.3%) disagreed that drug addicts indulge in criminal acts, 75.0% disagreed that drugs should be avoided because it distorts their sense of judgment, and 66.6% of the respondents agreed that young individuals see drug use as a means of escapism. Conclusions: The distribution of the participants with positive or negative behavioural perceptions of drug abuse is approximately equal with a slight increase in the negative perception group. Behavioural therapy for drug abuse is required to reduce the burden in the studied environment. Furthermore, this study forms the basis for creating more health intervention schemes to reduce the drug abuse burden.

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“…These changes in locomotion can be explained by observed alterations in the animals’ dopaminergic system resulting from chronic methylphenidate treatment and the environmental conditions (standard vs. enriched) in which they are raised ( Gill et al, 2013 ). Environmental enrichment has been shown to influence animals’ sensitization to modify their locomotion in response to methylphenidate ( Malone et al, 2022 ). Given the potential of this variable, it is relevant to continue studying whether an enriched environment can reverse the effects of a psychostimulant on animal locomotion.…”

Section: Introductionmentioning

confidence: 99%

Role of environmental enrichment on social interaction, anxiety, locomotion, and memory in Wistar rats under chronic methylphenidate intake

Herrera-Isaza,

Zárate-Guerrero,

Corredor

et al. 2023

Front. Behav. Neurosci.

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IntroductionChronic use of various compounds can have long-lasting effects on animal behavior, and some of these effects can be influenced by the environment. Many environmental enrichment protocols have the potential to induce behavioral changes.AimThe aim of the present study was to investigate how environmental enrichment can mitigate the effects of chronic methylphenidate consumption on the behavior of Wistar rats.MethodsThe animals were housed for 20 days under either an environmental enrichment protocol (which included tubes of different shapes) or standard housing conditions. After seven days, half of the rats received 13 days of oral administration of methylphenidate (2 mg/kg). After seven days, the rats underwent behavioral tests, including the elevated plus maze (anxiety), open field (locomotion), object-in-place recognition test (spatial memory), and a test for social interaction (social behavior).ResultsThe results showed that the enriched environmental condition reversed the enhanced time in the open arms of the elevated plus maze induced by methylphenidate (F[1,43] = 4.275, p = 0.045). Methylphenidate also enhanced exploratory rearing in the open field (F[1,43] = 4.663, p = 0.036) and the time spent in the open area of the open field (H[3] = 8.786, p = 0.032). The enriched environment mitigated the inhibition of social interaction with peers induced by methylphenidate (H[3] = 16.755, p < 0.001) as well as the preference for single exploratory behavior (H[3] = 9.041, p = 0.029).DiscussionThese findings suggest that environmental enrichment can counteract some of the effects of methylphenidate. These results are relevant for the clinical treatment of the long-lasting secondary effects associated with methylphenidate pharmacological treatment.

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Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review

Cited by 10 publications

References 117 publications

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

A Community-Based Study of Behavioural Perception of Psychoactive Drug Abuse in Southern Nigeria

Role of environmental enrichment on social interaction, anxiety, locomotion, and memory in Wistar rats under chronic methylphenidate intake

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