Neurobehavioral Effects of Amantadine After Pediatric Traumatic Brain Injury

Abstract

After traumatic brain injury, a 12-week course of AMH was safe and, according to parent report, improved behavior. AMH may have the potential to improve cognition in more recently injured children.

The Diagnosis and Management of Concussion in Children and Adolescents

“…131,132 Amantadine has been used for post-TBI cognitive and behavioral symptoms, but the results have also been inconsistent. 133,134 Moderate and severe TBI patients are included in some of these studies, highlighting the need for dedicated concussion treatment trials.…”

Contribution of Rating Scales to Intervention for Executive Dysfunction

“…For example, the BRIEF has been used to assess the effects of medications on executive functions in the everyday life of individuals with attention-deficit hyperactivity disorder (ADHD; Biederman et al, 2011;Dupaul et al, 2012;Findling, Ginsberg, Jain, & Gao, 2009;Maziade et al, 2009;Turgay et al, 2010;Yang et al, 2011), Tourette syndrome (Cummings, Singer, Krieger, Miller, & Mahone, 2002), traumatic brain injury (TBI; Beers, Skold, Dixon, & Adelson, 2005), hepatitis C virus (Rodrigue et al, 2011), major depressive disorder (Roth et al, 2012), and hypertension (Lande et al, 2010). It has also been employed to examine outcomes following interventions such as liver transplantation (Sorensen et al, 2011), chemotherapy in breast cancer (Kesler, Kent, & O'Hara, 2011;McDonald, Conroy, Smith, West, & Saykin, 2013), corticosteroid treatment in children with inflammatory bowel disease (Mrakotsky et al, 2013), and family-based intervention in TBI (Wade, Wolfe, Brown, & Pestian, 2005;Wade, Wolfe, & Pestian, 2004).…”

Pharmacological management of neurobehavioural sequelae of traumatic brain injury: A survey of current physiatric practice

“…However, in the last couple of decades only a handful of medications have been systematically studied. The few drugs that have been studied in experimental or quasi-experimental trials were methylphenidate [1,2], amantadine [3,4], Beers [5] propranolol, Meythaler [6,7] and cholinesterase inhibitors [8,9]. Given the dearth of randomized controlled trials and clinical practice guidelines, medication choices are thus empirical and based on anecdotal experience or on published case reports and series.…”

“…Valproic acid and its derivatives (VPA) (13) Lorazepam (9) Propranolol (8) Carbamazepine (8) Nadolol (6) Risperidone (8) Trazodone (6) Carbamazepine (5) Anger VPA (6) VPA (11) SSRI (5) Carbamazepine (7) Anxiety Buspirone (14) Buspirone (13) Paroxetine (7) Paroxetine (5) Depression Paroxetine (11) Paroxetine (11) Sertraline (10) Methylphenidate (5) Venlafaxine (10) Inattention…”