Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants

Grandjean, Philippe; Weihe, Pál; Burse, Virlyn W.; Needham, Larry L.; Storr-Hansen, E.; Heinzow, Birger; Debes, Fróði; Murata, Katsuyuki; Simonsen, Henrik Toft; Ellefsen, P; Budtz‐Jørgensen, Esben; Keiding, Niels; White, Roberta F.

doi:10.1016/s0892-0362(01)00155-6

Cited by 319 publications

(239 citation statements)

References 40 publications

(22 reference statements)

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“…At age 7 years, 21 prolongations of the peak I latency occurred as a result of 14 middle ear infection, but at age 14 years this trait was absent. A s p r e v i o u s l y r e p o r t e d f o r t h e r e s u l t s a t a g e 7 y e a r s , 26 concomitant prenatal exposure to PCBs, which occur in whale blubber sometimes eaten in the Faroes, did not influence the BAEP outcomes. Developmental exposure to PCBs is now thought to affect primarily cochlear function and impact on BAEP amplitudes rather than latencies.…”

Section: T H E M E H G -A S S O C I a T E D P R O L O N G A T I O N Omentioning

confidence: 87%

“…These results parallel those obtained at age 7 years. 26 All BAEP latencies were recorded with a sound pressure adjusted for audiometry results; no association between hearing thresholds and BAEP latencies was detected, except for peak I at a single sound frequency on one side only. Although deafness has been reported in severe congenital MeHg poisoning cases, 2 hearing loss is not a uniform finding in less serious childhood poisonings or in adult cases.…”

Section: E S P I T E T H E D E L a Y E D B A E P L A Tencies The Amentioning

confidence: 98%

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Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury

Murata

Weihe

Budtz‐Jørgensen

et al. 2004

The Journal of Pediatrics

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218

133

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Section: T H E M E H G -A S S O C I a T E D P R O L O N G A T I O N Omentioning

confidence: 87%

Section: E S P I T E T H E D E L a Y E D B A E P L A Tencies The Amentioning

confidence: 98%

Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury

Murata

Weihe

Budtz‐Jørgensen

et al. 2004

The Journal of Pediatrics

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218

133

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“…These findings were robust in analyses controlled for age, sex and confounders, and they persisted after exclusion of high-exposure participants (i.e., maternal hair-mercury concentrations above 10 μg/g) [18]. Ingestion of whale blubber causes exposure to lipophilic contaminants, notably polychlorinated biphenyls (PCBs), but the possible neurotoxic influence of this exposure did not explain the MeHg-associated neurobehavioral deficits [6,16,29]. The examination at age 14 years that is described in this paper included a clinical test battery similar to the one applied at age 7 years.…”

Section: Introductionmentioning

confidence: 95%

Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years

Debes

Budtz‐Jørgensen

Weihe

et al. 2006

Neurotoxicology and Teratology

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249

165

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A cohort of 1022 consecutive singleton births was generated during [1987][1988] in the Faroe Islands, where increased methylmercury exposure occurs from traditional seafood diets that include pilot whale meat. The prenatal exposure level was determined from mercury analyses of cord blood, cord tissue, and maternal hair. At age 14 years, 878 of 1010 living cohort members underwent detailed neurobehavioral examination. Eighteen participants with neurological disorders were excluded. Blood and hair samples obtained from the participants were analyzed for mercury. The neuropsychological test battery was designed based on the same criteria as applied at the examination at age 7 years. Multiple regression analysis was carried out and included adjustment for confounders. Indicators of prenatal methylmercury exposure were significantly associated with deficits in finger tapping speed, reaction time on a continued performance task, and cued naming. Postnatal methylmercury exposure had no discernible effect. These findings are similar to those obtained at age 7 years, and the relative contribution of mercury exposure to the predictive power of the multiple regression models was also similar. An analysis of the test score difference between results at 7 and 14 years suggested that mercury-associated deficits had not changed between the two examinations. In structural equation model analyses, the neuropsychological tests were separated into five groups; methylmercury exposure was significantly associated with deficits in motor, attention, and verbal tests. These findings are supported by independent assessment of neurophysiological outcomes. The effects on brain function associated with prenatal methylmercury exposure therefore appear to be multi-focal and permanent.

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“…The first cohort (Cohort 1) was formed between 1986 and 1987 [16,20], one (Cohort 3) was formed between 1997 and 2000 [21–23] and the most recent cohort, with necessary exposure data (Cohort 5), was formed between 2007 and 2009 [24–26]. …”

Section: Methodsmentioning

confidence: 99%

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

Timmermann¹,

Choi

Petersen

et al. 2017

International Journal of Circumpolar Health

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This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother–child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p’-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0–16%), 7% (95% CI = 0–14%) and 9% (95% CI = 2–17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention.

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Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants

Cited by 319 publications

References 40 publications

Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury

Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury

Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

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