Neuroanatomical Study of the A11 Diencephalospinal Pathway in the Non-Human Primate

Barraud, Quentin; Obeid, Ibrahim; Aubert, Incarnation; Barrière, Grégory; Contamin, Hugues; McGuire, Stephen A.; Ravenscroft, Paula; Porras, Grégory; Tison, François; Bézard, Erwan; Ghorayeb, Imad

doi:10.1371/journal.pone.0013306

Cited by 86 publications

(74 citation statements)

References 94 publications

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“…In rats, we did not find cells labeled in A11 following tracer or virus injection in the MLR. Importantly, A11 DA neurons do not express DAT in rats (46), primates (45), and humans (47), thus confirming that the DAT + innervation of the MLR that we report here in rats and humans does not originate from A11. However, the diencephalo-spinal dopaminergic projection originating from A11 could play a role in locomotor control (for review, see ref.…”

Section: Discussionsupporting

confidence: 86%

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A descending dopamine pathway conserved from basal vertebrates to mammals

Ryczko

Cone

Alpert

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

104

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Dopamine neurons are classically known to modulate locomotion indirectly through ascending projections to the basal ganglia that project down to brainstem locomotor networks. Their loss in Parkinson's disease is devastating. In lampreys, we recently showed that brainstem networks also receive direct descending dopaminergic inputs that potentiate locomotor output. Here, we provide evidence that this descending dopaminergic pathway is conserved to higher vertebrates, including mammals. In salamanders, dopamine neurons projecting to the striatum or brainstem locomotor networks were partly intermingled. Stimulation of the dopaminergic region evoked dopamine release in brainstem locomotor networks and concurrent reticulospinal activity. In rats, some dopamine neurons projecting to the striatum also innervated the pedunculopontine nucleus, a known locomotor center, and stimulation of the dopaminergic region evoked pedunculopontine dopamine release in vivo. Finally, we found dopaminergic fibers in the human pedunculopontine nucleus. The conservation of a descending dopaminergic pathway across vertebrates warrants re-evaluating dopamine's role in locomotion.D opaminergic neurons represent a vital neuromodulatory component essential for vertebrate motor control, and their loss in neurodegenerative disease is devastating. The meso-diencephalic dopamine (DA) neurons are known to provide ascending projections to the basal ganglia, which, in turn, provide input to cortical structure in mammals but also project caudally to the mesencephalic locomotor region (MLR), a highly conserved structure that controls locomotion in all vertebrates investigated to date (1-7; for review, see ref. 8). A growing body of evidence supports the view that basal ganglia connectivity is highly conserved among vertebrates, from lampreys to mammals (9-11; for review, see ref. 12), with some interspecies differences recently highlighted (13). As such, the homology between DA cell populations remains to be resolved in vertebrates. As a general rule, DA neurons from the meso-diencephalon send projections to the striatum in all vertebrates. In lampreys and teleosts, those neurons are located only in the diencephalon (posterior tuberculum), but in tetrapods and cartilaginous fishes (14) they are located in both the diencephalon and the mesencephalon. An increasing number of authors seem to agree with the hypothesis that at least some of the mesodiencephalic DA neurons located in the diencephalon are homologous in all vertebrates, and thus, homologous to at least a portion of the mammalian substantia nigra pars compacta (SNc)/ ventral tegmental area (VTA) (13, 15-19; for review, see ref. 20). Alternatively, it was suggested that the posterior tuberculum DA neurons projecting to the striatum in zebrafish are homologs of the mammalian DA neurons of the A11 group (21). This will be discussed below in light of the results of the present study.In lampreys, only a few meso-diencephalic DA neurons send ascending projections to the striatum (9, 22); the majority ...

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Section: Discussionsupporting

confidence: 86%

“…Another group of DA neurons, located in the hypothalamus (A11), sends descending projections to the spinal cord in lamprey (41), zebrafish (42), mice (43), rats (44), and primates (45) (Fig. S3B)] was transiently evoked following PT activation.…”

Section: Discussionmentioning

confidence: 99%

A descending dopamine pathway conserved from basal vertebrates to mammals

Ryczko

Cone

Alpert

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

104

View full text Add to dashboard Cite

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“…Finally, MPTP toxicity outside the brain should also be considered. Impact of MPTP on DA system in spinal cord (Barraud et al 2010) and even the enteric nervous system has been analyzed in that respect (Chaumette et al 2009).…”

Section: Mptp-induced Anatomo-pathologymentioning

confidence: 99%

Modeling Parkinson's Disease in Primates: The MPTP Model

Porras¹,

Li²,

Bézard³

2011

Cold Spring Harbor Perspectives in Medicine

151

107

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The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate models of Parkinson's disease (PD) reproduce most, although not all, of the clinical and pathological hallmarks of PD. The present contribution presents the possibilities offered by the MPTP monkey models of PD to readers with minimal knowledge of PD, emphasizing the diversity of species, route and regimen of administration, symptoms and pathological features. Readers would eventually find out that there is not a single MPTP monkey model of PD but instead MPTP monkey models of PD, each addressing a specific experimental need.

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“…MPTP-treated monkeys respond well to antiparkinsonian treatments like L-DOPA or apomorphine and, like human pathology, after the treatment develop dyskinesias. Recently, some studies have been taken in order to study and evaluate the nonmotor symptoms of the disease using this model [56][57][58][59][60][61]. This model has also been used for electrophysiological studies, leading to important findings, including the emergence of deep brain stimulation, which is currently the best surgical method to ameliorate symptoms in PD patients [62,63].…”

Section: Mptpmentioning

confidence: 99%

The Effect of Treadmill Exercise on Expression of α-synuclein and miRNA in MPTP Induced-mouse Models of Parkinson’s Disease

Moon¹,

Choi²,

Oh³

et al. 2017

Exerc Sci

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Neurological disorders can be modeled in animals so as to recreate specific pathogenic events and behavioral outcomes. Parkinson's Disease (PD) is the second most common neurodegenerative disease of an aging population, and although there have been several significant findings about the PD disease process, much of this process still remains a mystery. Breakthroughs in the last two decades using animal models have offered insights into the understanding of the PD disease process, its etiology, pathology, and molecular mechanisms. Furthermore, while cellular models have helped to identify specific events, animal models, both toxic and genetic, have replicated almost all of the hallmarks of PD and are useful for testing new neuroprotective or neurorestorative strategies. Moreover, significant advances in the modeling of additional PD features have come to light in both classic and newer models. In this review, we try to provide an updated summary of the main characteristics of these models as well as the strengths and weaknesses of what we believe to be the most popular PD animal models. These models include those produced by 6-hydroxydopamine (6-OHDA), 1-methyl-1,2,3,6-tetrahydropiridine (MPTP), rotenone, and paraquat, as well as several genetic models like those related to alpha-synuclein, PINK1, Parkin and LRRK2 alterations.

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Neuroanatomical Study of the A11 Diencephalospinal Pathway in the Non-Human Primate

Cited by 86 publications

References 94 publications

A descending dopamine pathway conserved from basal vertebrates to mammals

A descending dopamine pathway conserved from basal vertebrates to mammals

Modeling Parkinson's Disease in Primates: The MPTP Model

The Effect of Treadmill Exercise on Expression of α-synuclein and miRNA in MPTP Induced-mouse Models of Parkinson’s Disease

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