Neuroanatomical changes in early Parkinson’s disease with mild cognitive impairment: a VBM study; the Parkinson’s Disease Cognitive Impairment Study (PaCoS)

Donzuso, Giulia; Monastero, Roberto; Cicero, Calogero Edoardo; Luca, Antonina; Mostile, Giovanni; Giuliano, Loretta; Baschi, Roberta; Caccamo, M. L.; Gagliardo, Cesare; Palmucci, Stefano; Zappia, Mario

doi:10.1007/s10072-020-05034-9

Cited by 19 publications

(13 citation statements)

References 39 publications

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“…Compared with traditional region of interest (ROI) measurement, VBM can detect subtle brain structural abnormalities, thereby improving the statistical validity of morphological analysis (16). This method has been widely used in research on epilepsy, Parkinson's disease, Alzheimer's disease, and schizophrenia (17)(18)(19)(20), which can provide strong evidence to explain the underlying pathophysiological mechanisms of disease. Our research results can complement the previous imaging studies on anti-NMDAR encephalitis.…”

Section: Introductionmentioning

confidence: 99%

Cerebral gray matter volume changes in patients with anti-N-methyl-D-aspartate receptor encephalitis: A voxel-based morphometry study

Long

Zhao

et al. 2022

Front. Neurol.

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Background:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease with typical clinical features. Whether and how cerebral gray matter structural damage inherent to the disorder affects cognitive function in patients is still unclear. Therefore, this study aimed to explore the changes in cerebral gray matter volume and whether these alterations contribute to cognitive impairment and mood disorders.MethodsForty patients with anti-NMDAR encephalitis and forty healthy controls (HCs) matched for gender, age, and education were recruited. All participants underwent attention network tests (ANT), neuropsychological tests and magnetic resonance imaging (MRI). Voxel-based morphological analysis (VBM) and correlation analysis was performed on all participants. Finally, according to the course of disease, patients were divided into two groups: NMDARE_SD (short duration; course ≤ 2 years since diagnosis) and NMDARE_LD (long duration; course >2 years since diagnosis), to evaluate gray matter volume changes that differ as a function of disease course.ResultsCompared to HCs, patients with anti-NMDAR encephalitis showed decreased executive control ability and lower MoCA score, while increased anxiety and depression as reflected by HAMA and HAMD24 scores (all P < 0.05). In VBM analysis, patients showed decreased gray matter volume in bilateral thalamus, left medial prefrontal cortex (mPFC_L), left superior temporal gyrus (STG_L), and left rectus gyrus. In the analysis stratified by disease course, the NMDARE_LD group exhibited decreased gray matter volume in the left precuneus and right posterior cerebellar lobe compared to the NMDARE_SD group.ConclusionsPatients with anti-NMDAR encephalitis have cognitive, executive, and emotional dysfunction, and the sites of gray matter atrophy are concentrated in the thalamus, frontal lobe, and temporal lobe. These abnormalities may be involved in the process of cognitive and affective dysfunction.Patients with different courses of anti-NMDAR encephalitis have different brain atrophy sites. These results may help to clarify the contradiction between clinical and imaging manifestations of anti NMDAR encephalitis, which is worthy of further longitudinal studies.

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Section: Introductionmentioning

confidence: 99%

Cerebral gray matter volume changes in patients with anti-N-methyl-D-aspartate receptor encephalitis: A voxel-based morphometry study

Long

Zhao

et al. 2022

Front. Neurol.

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“…Previous reports have shown that the cerebellum is implicated in motor control ( De Zeeuw and Ten Brinke, 2015 ), emotion ( Koziol et al, 2014 ), and cognitive behavior ( Buckner, 2013 ). Research using VBM approaches have shown significant cerebellar GMV atrophy in patients with mild cognitive impairment ( Donzuso et al, 2021 ) and in those with major depressive disorder ( Depping et al, 2020 ). A previous study found reduced cerebellar degree centrality values in depressed patients with Parkinson’s disease ( Wang et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

The Predictive Potential of Altered Voxel-Based Morphometry in Severely Obese Patients With Meibomian Gland Dysfunction

Wang

Gao

et al. 2022

Front. Neurosci.

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ObjectiveTo investigate voxel-based morphometry (VBM) by using magnetic resonance imaging (MRI) in meibomian gland dysfunction patients with severe obesity (PATs) and to explore the application of VBM in the early diagnosis, prevention of cognitive impairment and targeted treatment of this disease.MethodsSixteen PATs and 12 healthy controls (HCs) were enrolled and underwent MRI. Whole-head images were analyzed using VBM and data were compared between groups using an independent samples t-test. Receiver operating characteristic (ROC) curves were utilized to assess the diagnostic value of this approach. Mini-mental state examination (MMSE) scores were used to assess cognitive impairment and were analyzed using an independent samples t-test.ResultsCompared with HCs, the VBM values in PATs were reduced in the left cerebellum and right thalamus but increased in the right brainstem, right precuneus and right paracentral lobule. The results of ROC curve analysis indicated that VBM may be useful in meibomian gland disease diagnosis. Comparison of MMSE scores between groups showed mild cognitive impairment in PATs.ConclusionPATs showed altered VBM values in some brain areas. These findings may provide information about the pathophysiology of meibomian gland dysfunction and may help to explain the underlying mechanisms of clinical manifestations in PATs, such as cognitive impairment. Abnormal VBM values in these brain areas may serve as predictive factors for development of meibomian gland disease in severely obese people and as indicators for individualized treatment.

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“…In fact, PD-MCI patients who converted to dementia in <3 (36) or 4 years (37) had greater widespread atrophy and cortical thinning in the frontal, insular, and left middle temporal lobes at baseline than non-converters, with frontal lobe atrophy being the strongest predictor of progression to dementia (37). These findings were reinforced by a cross-sectional study showing that patients who developed PD-MCI within 2 years of diagnosis exhibited greater atrophy in the superior frontal gyrus than those with later cognitive decline (40). In addition, longitudinal studies in PD-NC patients who converted to PD-MCI patients over time showed greater GM atrophy in the frontal, parietal, and temporal areas (32), as well as in the insular cortex and caudate nucleus (29,32,39).…”

Section: Grey Mattermentioning

confidence: 97%

Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease

et al. 2021

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Dementia and mild forms of cognitive impairment as well as neuropsychiatric symptoms (i. e., impulse control disorders) are frequent and disabling non-motor symptoms of Parkinson's disease (PD). The identification of changes in neuroimaging studies for the early diagnosis and monitoring of the cognitive and neuropsychiatric symptoms associated with Parkinson's disease, as well as their pathophysiological understanding, are critical for the development of an optimal therapeutic approach. In the current literature review, we present an update on the latest structural and functional neuroimaging findings, including high magnetic field resonance and radionuclide imaging, assessing cognitive dysfunction and impulse control disorders in PD.

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Neuroanatomical changes in early Parkinson’s disease with mild cognitive impairment: a VBM study; the Parkinson’s Disease Cognitive Impairment Study (PaCoS)

Cited by 19 publications

References 39 publications

Cerebral gray matter volume changes in patients with anti-N-methyl-D-aspartate receptor encephalitis: A voxel-based morphometry study

Cerebral gray matter volume changes in patients with anti-N-methyl-D-aspartate receptor encephalitis: A voxel-based morphometry study

The Predictive Potential of Altered Voxel-Based Morphometry in Severely Obese Patients With Meibomian Gland Dysfunction

Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease

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