Neuroanatomical and prognostic associations of depression in Parkinson’s disease
James B Badenoch,
Alvar Paris,
Benjamin Meir Jacobs
et al.
Abstract:BackgroundDepression is reported as a risk factor, prodromal feature and late consequence of Parkinson’s disease (PD). We aimed to evaluate the timing, neuroanatomy and prognostic implications of depression in PD.MethodsWe used data from 434 023 participants from UK Biobank with 14.1 years of follow-up. Multivariable regression models established associations of depression with incident PD and regional brain volumes. Cox proportional hazards models assessed prognostic associations of depression in PD with inci… Show more
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