Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis

Pezzoli, Stefania; Sánchez‐Valle, Raquel; Solanes, Aleix; Kempton, Matthew J.; Bandmann, Oliver; Smıth, Lee; Cagnin, Annachiara; Goldman, Jennifer G.; Merkitch, Doug; Firbank, Michael; Pagonabarraga, Javier; Kulisevsky, Jaime; Blanc‬, ‪Frederic; Verdolini, Norma; Venneri, Annalena; Raduà, Joaquim

doi:10.1016/j.neubiorev.2021.06.030

Cited by 27 publications

(39 citation statements)

References 130 publications

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“…In 20 % of the studies, it is not specified whether participants were taking levodopa medication ( Pezzoli et al, 2021b , Shine et al, 2015 ). In the rest of the studies, participants were under treatment for motor symptoms.…”

Section: Resultsmentioning

confidence: 99%

A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations

Spinosa

Brattico

Campo

et al. 2022

NeuroImage: Clinical

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Section: Resultsmentioning

confidence: 99%

A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations

Spinosa

Brattico

Campo

et al. 2022

NeuroImage: Clinical

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“…Contrasting findings may be due to methodological and clinical differences between studies, including those not distinguishing between hallucinations in different sensory modalities [14,24,25]. Occipital/occipito-temporal atrophy has been related to VH in previous studies of patients with AD and PD, and hypometabolism/hypoperfusion in these regions was found in hallucinating patients with PD and DLB [21,22,29,47,48]. In the present study, although the results of the independent comparisons of both AD sub-groups with CN participants seem to suggest a trend of divergent structural and metabolic alterations in VH and NVH patients (i.e., primarily occipital and temporal in VH and temporal in NVH), we detected no significant differences in the direct comparison between patients with and without VH contrary to our hypothesis.…”

Section: Discussionmentioning

confidence: 99%

A Multimodal Neuroimaging and Neuropsychological Study of Visual Hallucinations in Alzheimer’s Disease

Pezzoli

Manca

Cagnin

et al. 2022

JAD

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Background: Hallucinations in Alzheimer’s disease (AD) have been linked to more severe cognitive and functional decline. However, research on visual hallucinations (VH), the most common type of hallucinations in AD, is limited. Objective: To investigate the cognitive and cerebral macrostructural and metabolic features associated with VH in AD. Methods: Twenty-four AD patients with VH, 24 with no VH (NVH), and 24 cognitively normal (CN) matched controls were selected from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Differences in regional gray matter (GM) volumes and cognitive performance were investigated with whole brain voxel-based morphometry analyses of MRI structural brain scans, and analyses of neuropsychological tests. Glucose metabolic changes were explored in a subsample of patients who had FDG-PET scans available. Results: More severe visuoconstructive and attentional deficits were found in AD VH compared with NVH. GM atrophy and hypometabolism were detected in occipital and temporal areas in VH patients in comparison with CN. On the other hand, NVH patients had atrophy and hypometabolism mainly in temporal areas. No differences in GM volume and glucose metabolism were found in the direct comparison between AD VH and NVH. Conclusion: In addition to the pattern of brain abnormalities typical of AD, occipital alterations were observed in patients with VH compared with CN. More severe visuoconstructive and attentional deficits were found in AD VH when directly compared with NVH, and might contribute to the emergence of VH in AD.

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“…Complex visual hallucinations are a frequent feature of Parkinson’s disease and Lewy body dementia ( O'Brien et al, 2020 ), where they may be caused by a combination of visual and attentional deficits. Structural imaging studies in these conditions have found complex VH associated with reduced grey matter in occipital, inferior temporal and midline cortex ( Pezzoli et al, 2021 ) with some reports of reduced hippocampal volume ( Ibarretxe-Bilbao et al, 2008 , Watanabe et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Investigation of structural brain changes in Charles Bonnet Syndrome

Firbank

Morgan

Collerton

et al. 2022

NeuroImage: Clinical

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Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis

Cited by 27 publications

References 130 publications

A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations

A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations

A Multimodal Neuroimaging and Neuropsychological Study of Visual Hallucinations in Alzheimer’s Disease

Investigation of structural brain changes in Charles Bonnet Syndrome

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