Neuroactive steroids, negative affect, and nicotine dependence severity in male smokers

Marx, Christine E.; Trost, William T.; Shampine, Lawrence J.; Behm, Frédérique M.; Giordano, Louis A.; Massing, Mark W.; Rose, Jed E.

doi:10.1007/s00213-005-0226-x

Cited by 47 publications

(39 citation statements)

References 89 publications

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“…Interestingly, IV cocaine also stimulated significant increases in DHEA and cortisol that were similar in time course and magnitude to smoking a high-nicotine cigarette (Mendelson et al, , 2003. We have suggested previously that the significant nicotine-induced increases in cortisol and DHEA may contribute to the abuse-related effects of cigarette smoking (Mendelson et al, 2005) and DHEA has also been suggested as a potential medication for smoking cessation (Marx et al, 2006).…”

Section: Tolerance To Nicotine's Biological and Subjective Effectsmentioning

confidence: 58%

“…Although the role of cortisol in nicotine dependence is unclear, a decrease in cortisol after smoking cessation appears to predict a higher risk for relapse (al'Absi et al, 2004;Rasmusson et al, 2006). DHEA has recently been suggested as a medication to facilitate smoking cessation, in part because levels of its sulfated derivative, DHEAs, were inversely correlated with several measures of nicotine dependence and negative affect in smokers (Marx et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Smoking Successive Low- and High-Nicotine Cigarettes on Hypothalamic–Pituitary–Adrenal Axis Hormones and Mood in Men

Mendelson

Goletiani

Sholar

et al. 2007

Neuropsychopharmacol

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Smoking one cigarette produces rapid nicotine dose-related increases in hypothalamic-pituitary-adrenal (HPA) axis hormones, mood, and heart rate, but relatively little is known about the effects of smoking several cigarettes successively. Twenty-four healthy adult men who met Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria for nicotine dependence provided informed consent. After overnight abstinence from smoking, men smoked three low-or high-nicotine cigarettes for 4 min each at 60 min intervals. Samples for nicotine and hormone analysis, Visual Analog Scale (VAS) ratings of subjective effects and heart rate were collected at 4, 8, 12, 16, 20, 30, 40, and 50 min after each cigarette. After low-nicotine cigarettes, nicotine levels, adrenocorticotropin hormone, and heart rate did not increase significantly, cortisol and dehydroepiandrosterone decreased significantly, and positive VAS ratings were lower but parallel to ratings after high-nicotine cigarette smoking. After high-nicotine cigarettes, peak nicotine levels increased monotonically. HPA axis hormones increased after smoking, but peak levels did not differ significantly after successive high-nicotine cigarettes. Positive VAS ratings and heart rate increased after each high-nicotine cigarette, but peak levels were lower after smoking the second and third cigarette. 'Craving' decreased significantly after smoking both low-and high-nicotine cigarettes, then gradually increased during the 60 min interval between cigarettes. These data are consistent with clinical reports that the first cigarette after overnight nicotine abstinence is most salient. Tolerance to the subjective and cardiovascular effects of nicotine developed rapidly during repeated cigarette smoking, but nicotine-stimulated increases in HPA axis hormones did not change significantly.

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Section: Tolerance To Nicotine's Biological and Subjective Effectsmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Effects of Smoking Successive Low- and High-Nicotine Cigarettes on Hypothalamic–Pituitary–Adrenal Axis Hormones and Mood in Men

Mendelson

Goletiani

Sholar

et al. 2007

Neuropsychopharmacol

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“…The intra-assay coefficient of variation (CV) is 4.7 percent, and the interassay CV is 8.4 percent. Plasma levels of ALLO were measured by gas chromatography-mass spectrometry (GC-MS) after separation of the steroids by high-performance liquid chromatography using previously published methods [43][44]. ALLO levels were identified based on their GC-MS retention time characteristics; the definitive structural identification of each neurosteroid is provided by its unique mass fragmentation pattern.…”

Section: Neurohormone Assaysmentioning

confidence: 99%

Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study

Scioli-Salter¹,

Forman

Otis³

et al. 2016

J Rehabil Res Dev

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Abstract-This pilot study assessed the effects of cardiopulmonary exercise testing and cardiorespiratory fitness on plasma neuropeptide Y (NPY), allopregnanolone and pregnanolone (ALLO), cortisol, and dehydroepiandrosterone (DHEA), and their association with pain sensitivity. Medication-free traumaexposed participants were either healthy (n = 7) or experiencing comorbid chronic pain/posttraumatic stress disorder (PTSD) (n = 5). Peak oxygen consumption (VO 2 ) during exercise testing was used to characterize cardiorespiratory fitness. Peak VO 2 correlated with baseline and peak NPY levels (r = 0.66, p < 0.05 and r = 0.69, p < 0.05, respectively), as well as exercise-induced changes in ALLO (r = 0.89, p < 0.001) and peak ALLO levels (r = 0.71, p < 0.01). NPY levels at the peak of exercise correlated with pain threshold 30 min after exercise (r = 0.65, p < 0.05), while exercise-induced increases in ALLO correlated with pain tolerance 30 min after exercise (r = 0.64, p < 0.05). In contrast, exercise-induced changes in cortisol and DHEA levels were inversely correlated with pain tolerance after exercise (r = -0.69, p < 0.05 and r = -0.58, p < 0.05, respectively). These data suggest that cardiorespiratory fitness is associated with higher plasma NPY levels and increased ALLO responses to exercise, which in turn relate to pain sensitivity. Future work will examine whether progressive exercise training increases cardiorespiratory fitness in association with increases in NPY and ALLO and reductions in pain sensitivity in chronic pain patients with PTSD.Abbreviations: ALLO = allopregnanolone and pregnanolone, ANOVA = analysis of variance, BMI = body mass index, CPT = cold pressor test, CPX = cardiopulmonary exercise testing, CSF = cerebrospinal fluid, CSU = clinical studies unit, CV = coefficient of variation, DHEA = dehydroepiandrosterone, DHEA(S) = DHEA-sulfate, DSM-IV = Diagnostic and Statistical Manual of Mental Disorders-4th Edition, EKG = electrocardiogram, GABA = gamma-aminobutyric acid, GC-MS = gas chromatography-mass spectrometry, IV = intravenous line, NPY = neuropeptide Y, OEF = Operation Enduring Freedom, OIF = Operation Iraqi Freedom, PTSD = posttraumatic stress disorder, RIA = radioimmunoassay, TC = trauma-exposed healthy control, VA = Department of Veterans Affairs, VO 2 = oxygen consumption.

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“…However, alcohol-dependent patients were almost all nicotine-dependent while controls were not. Although a previous study reported that cigarette smoking in abstinent alcohol-dependent subjects did not alter the pituitary-adrenal response to a pharmacological challenge (Anthenelli et al, 2001), a more recent study found that 3α,5α-THP levels may be up-regulated in smokers and dehydroepiandrosterone sulfate levels may predict nicotine dependence (Marx et al, 2006). Indeed, acute administration of nicotine alters pregnenolone, progesterone, 3α,5α-THP and 3α,5α-THDOC levels in rat brain and plasma (Porcu et al, 2003).…”

Section: Discussionmentioning

confidence: 92%

Differential hypothalamic–pituitary–adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects

Porcu

O'Buckley

Morrow

et al. 2008

Psychoneuroendocrinology

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SummaryEthanol and the neuroactive steroids have interactive neuropharmacological effects and chronic ethanol administration blunts the ethanol-induced increase in neuroactive steroid levels in rodent plasma and brain. Few studies have explored neuroactive steroid regulation in alcohol-dependent human subjects. In fact, the regulation of adrenal neuroactive steroids has not been well defined in healthy controls. We thus explored the regulation of two neuroactive steroids, pregnenolone sulfate (PREG-S) and deoxycorticosterone, by pharmacological challenges to the hypothalamic-pituitaryadrenal (HPA) axis in healthy controls and one-month abstinent alcohol-dependent patients with cooccurring nicotine dependence. Plasma levels of PREG-S and deoxycorticosterone were measured by radioimmunoassay in controls and alcohol-dependent patients after challenges of naloxone, ovine corticotrophin releasing hormone (oCRH), dexamethasone, cosyntropin, and cosyntropin following high-dose dexamethasone. In addition, basal diurnal measures of both hormones were obtained. PREG-S plasma levels in healthy controls were increased by cosyntropin challenge (with and without dexamethasone pretreatment) and decreased by dexamethasone challenge. However, PREG-S concentrations were not altered by naloxone or oCRH challenges, suggesting that PREG-S is not solely regulated by hypothalamic or pituitary stimulation. Deoxycorticosterone, in contrast, is regulated by HPA challenge stimulation in a manner similar to cortisol. Alcohol-dependent patients had a blunted PREG-S response to cosyntropin (with and without dexamethasone pretreatment). Furthermore, the time to peak deoxycorticosterone response following oCRH was delayed in alcoholdependent patients compared to controls. These results indicate that plasma PREG-S and deoxycorticosterone levels are differentially regulated by HPA axis modulation in human plasma. Further, alcohol-dependent patients show a blunted PREG-S response to adrenal stimulation and a delayed deoxycorticosterone response to oCRH challenge.

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Neuroactive steroids, negative affect, and nicotine dependence severity in male smokers

Cited by 47 publications

References 89 publications

Effects of Smoking Successive Low- and High-Nicotine Cigarettes on Hypothalamic–Pituitary–Adrenal Axis Hormones and Mood in Men

Effects of Smoking Successive Low- and High-Nicotine Cigarettes on Hypothalamic–Pituitary–Adrenal Axis Hormones and Mood in Men

Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study

Differential hypothalamic–pituitary–adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects

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