Neuroactive steroids in pregnancy: Key regulatory and protective roles in the foetal brain

Hirst, Jonathan J.; Kelleher, Meredith A.; Walker, David; Palliser, Hannah K.

doi:10.1016/j.jsbmb.2013.04.002

Cited by 77 publications

(56 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, 3xTg-AD mice did not show the positive correlations in the levels of PREG and DHP and in the levels of THP and isopregnanolone that were detected in young and older WT mice, respectively [186]. In addition, THP, and therefore 5α-Rs, participates in brain maturation and protection during late gestation and in newborns [195].…”

Section: Effects Of 5α-ri Therapy On Neurobehavioral Functions and Nementioning

confidence: 78%

Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know?

Traish

Melcangi

Bortolato

et al. 2015

Rev Endocr Metab Disord

View full text Add to dashboard Cite

Steroids are important physiological orchestrators of endocrine as well as peripheral and central nervous system functions. One of the key processes for regulation of these molecules lies in their enzymatic processing by a family of 5α-reductase (5α-Rs) isozymes. By catalyzing a key rate-limiting step in steroidogenesis, this family of enzymes exerts a crucial role not only in the physiological control but also in pathological events. Indeed, both 5α-R inhibition and supplementation of 5α-reduced metabolites are currently used or have been proposed as therapeutic strategies for a wide array of pathological conditions. In particular, the potent 5α-R inhibitors finasteride and dutasteride are used in the treatments of benign prostatic hyperplasia (BPH), as well as in male pattern hair loss (MPHL) known as androgenetic alopecia (AGA). Recent preclinical and clinical findings indicate that 5α-R inhibitors evoke not only beneficial, but also adverse effects. Future studies should investigate the biochemical and physiological mechanisms that underlie the persistence of the adverse sexual side effects to determine why a subset of patients is afflicted with such persistence or irreversible adverse effects. Also a better focus of clinical research is urgently needed to better define those subjects who are likely to be adversely affected by such agents. Furthermore, research on the non-sexual adverse effects such as diabetes, psychosis, depression, and cognitive function are needed to better understand the broad spectrum of the effects these drugs may elicit during their use in treatment of AGA or BPH. In this review, we will summarize the state of art on this topic, overview the key unresolved questions that have emerged on the pharmacological targeting of these enzymes and their products, and highlight the need for further studies to ascertain the severity and duration of the adverse effects of 5α-R inhibitors, as well as their biological underpinnings.

show abstract

Section: Effects Of 5α-ri Therapy On Neurobehavioral Functions and Nementioning

confidence: 78%

Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know?

Traish

Melcangi

Bortolato

et al. 2015

Rev Endocr Metab Disord

View full text Add to dashboard Cite

show abstract

“…Neuroactive steroids act as important physiological regulators of nervous function with roles in mood, behavior, reproduction, and cognition and act as protective agents in models of injury and disease, including experimental models of Alzheimer ' s disease (AD), traumatic brain injury, stroke, autism, and mood disorders (Melcangi et al, 2008;Panzica et al, 2012;Schumacher et al, 2012). Moreover, neuroactive steroids exert key regulatory and protective roles in the fetal brain (Hirst et al, 2013). Recently, many groups have initiated research in the field of neuroactive steroid-induced neuroprotection.…”

Section: Introductionmentioning

confidence: 99%

17β-estradiol attenuates ketamine-induced neuroapoptosis and persistent cognitive deficits in the developing brain

Wang

et al. 2014

Brain Research

View full text Add to dashboard Cite

“…During late gestation, Allo concentrations are elevated in the fetal brain. Because stress can influence Allo levels (Hirst et al, 2014), the results reported here suggest that GS attenuated Allo levels in a sex-specific fashion.…”

Section: Sex-based Differences In the Effects Of Gestational Stress Omentioning

confidence: 53%

Consequences of gestational stress on GABAergic modulation of respiratory activity in developing newborn pups

Delhaes

Fournier

Tolsa

et al. 2014

Respiratory Physiology & Neurobiology

View full text Add to dashboard Cite

Neuroactive steroids in pregnancy: Key regulatory and protective roles in the foetal brain

Cited by 77 publications

References 96 publications

Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know?

Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know?

17β-estradiol attenuates ketamine-induced neuroapoptosis and persistent cognitive deficits in the developing brain

Consequences of gestational stress on GABAergic modulation of respiratory activity in developing newborn pups

Contact Info

Product

Resources

About