Neuro-steroids: 3β-hydroxy-δ5-derivatives in rat and monkey brain

Röbel, P; Bourreau, Eliane; Corpéchot, C.; Dang, D. C.; Halberg, F; Clarke, Christine L.; Haug, Marc; Schlegel, M. L.; Synguélakis, Monique; Vourc’h, Claire; Baulieu, Étienne-Émile

doi:10.1016/0022-4731(87)90133-6

Cited by 174 publications

(64 citation statements)

References 12 publications

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“…3) during nervous system activity, thus ensuring near-optimal modulation oftranscription ofIEGs requiredforfacilitation ofthe plastic changes in memory processes. P and PS, major steroidal constituents of mammalian brain, are formed in oligodendrocytes and probably also in astrocytes (44)(45)(46)(47)(48) from cholesterol by the side-chain cleaving enzyme, cytochrome P-450,CC, independently of peripheral sources. High levels of P, PS, DHEA, and DHEAS were found in cranial nerves and in various regions of human brain (49).…”

Section: I0mentioning

confidence: 99%

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

Flood

Morley

Roberts

1992

Proc. Natl. Acad. Sci. U.S.A.

395

184

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Immediate post-training intracerebroventricular administration to male mice of pregnenolone (P), pregnenolone sulfate (PS), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, or aldosterone caused improvement of retention for footshock active avoidance training, while estrone, estradiol, progesterone, or 16.8-bromoepiandrosterone did not. Dose-response curves were obtained for P, PS, DHEA, and testosterone. P and PS were the most potent, PS showing significant effects at 3.5 fmol per mouse. The active steroids did not show discernible structural features or known membrane or biochemical effects that correlated with their memory-enhancing capacity. The above, together with the findings that DHEA acted even when given at 1 hr after training and that P, PS, and DHEA improved retention over a much wider dose range than do excitatory memory enhancers, led to the suggestion that the effects of the active steroids converge at the facilitation of transcription of immediate-early genes. P and PS, for which receptors have not yet been demonstrated, may exert their effects by serving as precursors for the formation of a panoply of different steroids, ensuring near-optimal modulation of transcription of immediate-early genes required for achieving the plastic changes of memory processes. Low serum levels of P in aging and the increases of cancer and behavioral disorders in individuals receiving drugs that block synthesis of cholesterol, the immediate precursor of P, suggest possible clinical utility for P.

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Section: I0mentioning

confidence: 99%

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

Flood

Morley

Roberts

1992

Proc. Natl. Acad. Sci. U.S.A.

395

184

View full text Add to dashboard Cite

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“…The new concept that steroids could be synthesized de novo in the brain derived from observations made by Baulieu and colleagues. They found that several steroids such as pregnenolone, dehydroepiandrosterone, and their sulfate and lipoidal esters highly accumulated within the brain of several mammalian species (Corpéchot et al, 1981(Corpéchot et al, , 1983Robel and Baulieu, 1985;Lanthier and Patwardhan, 1986;Robel et al, 1986Robel et al, , 1987Jo et al, 1989;Mathur et al, 1993). The brain content of these steroids remained constant even after the removal of peripheral steroids by procedures such as adrenalectomy, castration and hypophysectomy.…”

Section: Introduction To Neurosteroid Research (1) Classical Concept:mentioning

confidence: 92%

Biosynthesis and Biological Actions of Neurosteroids in Brain Neurons

Tsutsui

2001

Zoological Science

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“…The synthesis of neurosteroids in central nervous system have been well documented (14,46,47,67). Neurosteroids have been widely recognized to modulate brain cell properties and functions (3, 10, 17, 36).…”

mentioning

confidence: 99%

A new strategy in treatment of neurodegenerative diseases: Neurosteroids

Unknown¹

2013

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:Steroid synthesized from cholesterol in the central nervous system independently of gonads and adrenal glands has been defined as neurosteroids. Neurosteroids are synthesized in many species of vertebrate and invertebrate nervous systems. Neurosteroids affects the many brain functions. The expression of enzymes catalyzing the synthesis of neurosteroids and the neurosteroid levels are changes in diseases of the nervous system. It has been well documented that neurosteroids protective role on the neurons. Neurosteroids reduces the disorders associated with nervous system in neurodegenerative diseases and can be used as preventive and therapeutic in these diseases.

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Neuro-steroids: 3β-hydroxy-δ5-derivatives in rat and monkey brain

Cited by 174 publications

References 12 publications

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

Biosynthesis and Biological Actions of Neurosteroids in Brain Neurons

A new strategy in treatment of neurodegenerative diseases: Neurosteroids

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