Neuro-scientific measures of study (S) and test (T) presentation program effects

Izawa, Chizuko; Hayden, Robert G.; Franklin, Michael J.; Katkin, Edward S.

doi:10.1037/e537102012-487

Cited by 1 publication

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“…[31][32][33] Control over the stress during the draw enables preservation of the cross-sectional geometry of the preform, a macroscopic template of the fi nal device, while features are reduced by up to 200 times and the length is scaled accordingly, producing hundreds of meters of fi ber. [ 34 ]…”

Section: Design and Fabricationmentioning

confidence: 99%

Polymer Fiber Probes Enable Optical Control of Spinal Cord and Muscle Function In Vivo

Froriep

Koppes

et al. 2014

Adv Funct Materials

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Restoration of motor and sensory functions in paralyzed patients requires the development of tools for simultaneous recording and stimulation of neural activity in the spinal cord. In addition to its complex neurophysiology, the spinal cord presents technical challenges stemming from its flexible fibrous structure and repeated elastic deformation during normal motion. To address these engineering constraints, we developed highly flexible fiber probes, consisting entirely of polymers, for combined optical stimulation and recording of neural activity. The fabricated fiber probes exhibit low-loss light transmission even under repeated extreme bending deformations.Using our fiber probes, we demonstrate simultaneous recording and optogenetic stimulation of neural activity in the spinal cord of transgenic mice expressing the light sensitive protein channelrhodopsin 2 (ChR2). Furthermore, optical stimulation of the spinal cord with the polymer fiber probes induces on-demand limb movements that correlate with electromyographical (EMG) activity.

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Section: Design and Fabricationmentioning

confidence: 99%