Neuro-protective and Neuro-curative effect of Vernonia Amygdalina in rat model of neurodegenerative disease

Neurobehavioral, histopathological and immunohistochemical effects of Ginkgo biloba and Cichorium intybus hydro-alcoholic extracts in experimentally alzheimer rats

“…Hippocampus plays a vital role in memory formation and retrieval. While traditionally believed to primarily contribute to declarative memory, current studies suggest that it may also have a role in other cognitive functions such as short-term memory, creativity, and decision-making, which are not directly associated with declarative memory (Ajeleti et al, 2023) [2] .…”

“…According to Ajeleti et al (2023) [2] the functions of certain learning and memory have been associated with different areas of the brain such as the hippocampus and cerebellum. While the hippocampus is associated with memory of new words, faces, place and event, cerebellum has been associated with memory of learning new skills like playing an instrument etc.…”

“…Many reports suggest that Aβ is a major pathological characteristic of AD additionally, tau protein is hyperphosphorylated in AD and accumulates in neurons. This causes abnormal mitochondrial dynamics, which, in turn, decrease the dendritic protein and dendritic spines, resulting in hippocampal-based learning and memory impairment (Ajeleti et al, 2023) [2] . This is because ALCL3 reduces cerebral glucose uptake, dulls brain insulin receptors, reduces PI3K-AKT signaling activity, and raises the activity of glycogen synthase kinase 3β (Adeli et al, 2019) [1] .…”