Neuro-otological Findings After Radiosurgery for Acoustic Neurinomas

Ito, Ken; Kurita, Hiroki; Sugasawa, Keiko; Okuno, Taeko; Mizuno, Masahiro; Sasaki, Tomio

doi:10.1001/archotol.1996.01890230075014

Cited by 30 publications

(13 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 74 articles, involving 5,825 patients, met the criteria of the established protocol and were evaluated (Supplementary Table 1), 2,4,5,10,17,19,26,29,35,41,[43][44][45][46]53,[56][57][58]60,[62][63][64] and the overall rate of hearing preservation in these studies was 57% (Table 1). 1,[11][12][13]28,39,47,55,62,63,[94][95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110]<...>…”

Section: Systematic Analysismentioning

confidence: 99%

“…Because of the numerous variables associated with assessing hearing preservation after radiosurgery in the literature, the hearing preservation rate after radiosurgery is not well defined. 37,53,54 The reported rates of hearing preservation vary between 11% and 77%, with most recent reports between 50% and 70% range. 4,11,18,[28][29][30]35,39,44,46,[53][54][55][56][57][58][59][60][61][62][63][64] Clearly, the reported outcomes do not provide the clinician with a consensus estimate of expected hearing preservation outcomes when counseling patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hearing preservation after stereotactic radiosurgery for vestibular schwannoma: A systematic review

Yang

Aranda

Han

et al. 2009

Journal of Clinical Neuroscience

130

View full text Add to dashboard Cite

Section: Systematic Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hearing preservation after stereotactic radiosurgery for vestibular schwannoma: A systematic review

Yang

Aranda

Han

et al. 2009

Journal of Clinical Neuroscience

130

View full text Add to dashboard Cite

“…The results of gamma knife radiosurgery (GKRS) in vestibular schwannoma (VS) are, in terms of hearing preservation, generally comparable to, or better than, those of microsurgery. [1][2][3] Furthermore, significant correlations exist between hearing loss, tumor size and treatment dose. 1,2,4 However, the significance of electrophysiological findings such as auditory brainstem responses (ABR) have not been investigated previously.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Furthermore, significant correlations exist between hearing loss, tumor size and treatment dose. 1,2,4 However, the significance of electrophysiological findings such as auditory brainstem responses (ABR) have not been investigated previously. In this prospective study we analyzed hearing outcomes after GKRS for VS and sought to identify the relevant preoperative prognostic factors.…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors of hearing preservation after gamma knife radiosurgery for vestibular schwannoma

Kim

Chung

Kong

et al. 2010

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

“…Stereotactic radiosurgery (SRS) is associated with an increased toxicity to the facial and trigeminal nerves, as compared with FSRT. With FSRT, rates of treatment-related toxicity to the facial nerve of 0-3% can be found in the literature [15][16][17][18][19][20][21][22]. With microsurgery, the rate of cranial nerve toxicity depends strongly on the size of the vestibular schwannoma.…”

Section: Discussionmentioning

confidence: 99%

Tomotherapy for neurofibromatosis Type 2: case report and review of the literature

Lee

Sl²,

Huang³

et al. 2010

BJR

View full text Add to dashboard Cite

ABSTRACT. Neurofibromatosis 2 (NF2) results in multiple central nervous system tumours. In this case report, the patient has one vestibular schwannoma, one trigeminal schwannoma and two meningiomas developed before the age of 30. Aiming to treat three targets at one fraction with minimal interaction and overlapping doses to normal tissue, the sophisticated equipment of tomotherapy was utilised for frameless stereotaxy; tomotherapy delivered intensity-modulated, rotational radiation therapy using a fan-beam delivery. Daily CT scans with the inbuilt CT scanner were also performed as part of the image-guided radiotherapy. The course of fractionated stereotactic radiotherapy consisted of eight fractions given three times per week with an overall treatment time of 17 days. For the meningioma over left parietal vertex, 4.5 Gy per fraction was given at 36 Gy/8 Fr/17 days. For the meningioma over anterior cerebral falx, 4 Gy per fraction was given at 32 Gy/8 Fr/17 days. For the two schwannomas as one target, 5 Gy per fraction was given at 40 Gy/8 Fr/17 days. The acute effect of the treatment was alopecia and mild headache. Subsequent follow-up confirmed clinical improvement. This is the first reported case of clinical experience with tomotherapy in the management of NF2. Neurofibromatosis 2 (NF2) is a slow-growing and nonmalignant inherited cancer syndrome with an estimated incidence of 1:40 000 [1]. The diagnosis is often made in the second or third decade of life. All patients have been found to have some mutation of the same gene located on chromosome 22. Statistically, one-half of cases are inherited and one-half are the result of de novo mutations. Inactivation of the NF2 gene and loss of expression of its products, merlin or schwannomin, has been reported for all NF2-associated tumours [2]. The autosomal dominant genetic predisposition to the development of various neural crest cell neoplasms is characteristic [3]. The principal treatment for symptomatic NF2 in our institute consists of surgical intervention accompanied by either radiotherapy for residual tumours or observation. Radiotherapy can be reserved for recurrence. There is no therapy for the underlying disorder of cell function caused by the genetic mutation.Multiple central nervous system (CNS) tumours are often the consequence of the development of NF2. In most applications of radiotherapy, including arc therapy, stereotactic radiosurgery and Gamma Knife, different dosage for different lesions in one single treatment course is not achievable. By contrast, tomotherapy is able to carry out the task of giving different doses to different lesions with minimal overlapping to reduce significant sequelae [4][5][6]. Case reportA 37-year-old woman presented to our Radiation Oncology outpatient department with increased frequency and intensity of headache, vertigo, unsteadiness and left facial numbness. Tracing her history back 10 years, when she initially developed tinnitus along with hearing impairment, MRI of the head then revealed a mass in the left cerebello...

show abstract

Neuro-otological Findings After Radiosurgery for Acoustic Neurinomas

Cited by 30 publications

References 15 publications

Hearing preservation after stereotactic radiosurgery for vestibular schwannoma: A systematic review

Hearing preservation after stereotactic radiosurgery for vestibular schwannoma: A systematic review

Prognostic factors of hearing preservation after gamma knife radiosurgery for vestibular schwannoma

Tomotherapy for neurofibromatosis Type 2: case report and review of the literature

Contact Info

Product

Resources

About