Neuro-Ophthalmology Annual Review

Golnik, Karl C.

doi:10.1097/apo.0000000000000147

Cited by 1 publication

(5 citation statements)

References 95 publications

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“…Therefore, if there is not a clear clinical diagnosis of typical ON, image tests should be done because a diagnosis`s delate may suppose a life threatening condition [13]. The treatment is basically etiological with antibiotics, corticosteroids and/ or surgery [10].…”

Section: Toxic and Nutritional Deficiency Optic Neuropathies Are Usuallymentioning

confidence: 99%

“…The main treatment consists in withdrawing the toxic agent (methanol, ethanol, etc.) and vitamins supplementation, but a lot more treatments are actually being investigated [10]. In a peripapillary edema without or minimal vision loss, we must suspect ICH.…”

Section: Toxic and Nutritional Deficiency Optic Neuropathies Are Usuallymentioning

confidence: 99%

“…Hereditary, post-traumatic and post-radiotherapy optic neuropathy has clear personal records. Nonetheless, some optic neuropathies considered hereditary, such as Leber's hereditary optic neuropathy (LHON), can onset without clear family records [10]. Nowadays, there is not an effective treatment for LHON [11].…”

Section: Toxic and Nutritional Deficiency Optic Neuropathies Are Usuallymentioning

confidence: 99%

“…Recently has been reported the significant correlation between RNFL thinning and atrophy of the posterior visual pathways and visual ina cross-sectional study with 100 patients with MS and posterior visual pathway damage [52]. Karl C Golnik suggests in a recent review that this could mean the possibility of transsynaptic degeneration [10]. Neither the presence or absence of disc edema, or it`s severity, have a prognosis value for visual outcome, RNFL thinning or VF defects in acute phase.…”

Section: Marques Et Al Have Recently Reported a Retrospectively Evalumentioning

confidence: 99%

“…The exact pathogenic mechanisms for either ischemic or inflammation of the optic nerve remains unknown. Nowadays, there is not an effective treatment in terms of recovery to normal visual acuity, visual field or contrast sensitivity in neither of them [10,12].…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis Approach of Optic Neuritis

Francisco¹,

Lorena²

2015

J Neurol Neurophysiol

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The approach of the etiology of an optic neuropathy can be difficult for both ophthalmologists and neurologists, because neither the appearance of the optic disc, the perimetry, or the findings in Optical Coherence Tomography (OCT) or Magnetic Resonance Imaging (MRI) are specific. Clinical features common to optic neuropathies are vision loss, visual fields scotomas and dyschromatopsia. Pain is a variable feature that, when is present, suggest an inflammatory disorder. Relative afferent pupilary defect is a required clinical finding for the diagnosis of unilateral optic neuropathy. The term "Typical optic neuritis" (ON) has been widely used to design a unilateral ON that presents in a young patient with an acute or subacute presentation, with pain worsened with eye movements and generally good prognosis. In this scenario, idiopathic or Multiple Sclerosis (MS) are the most likely etiologies. Therefore, in these cases, brain MRI with gadolinium contrast should be performed in order to establish the risk of conversion to MS. OCT is a useful test to evidence the retinal nerve fiber layer and ganglion cell-inner plexiform layer changes. Any modification of the mentioned clinical pattern should be consider "atypical" and further investigation is necessary in order to discard other possibilities such as ischemic, autoimmune, compressive-infiltrative, hereditary, toxic, nutritional deficiency, posttraumatic, postradiotherapy or intracraneal hypertension. Therefore, we must follow a rational algorism from the most common cause to the most unlikely in each case, with a well-defined previous distinction of the typical and atypical features, because both the early diagnosis and treatment are overriding in the second ones.

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Section: Toxic and Nutritional Deficiency Optic Neuropathies Are Usuallymentioning

confidence: 99%

Section: Toxic and Nutritional Deficiency Optic Neuropathies Are Usuallymentioning

confidence: 99%

Section: Toxic and Nutritional Deficiency Optic Neuropathies Are Usuallymentioning

confidence: 99%

Section: Marques Et Al Have Recently Reported a Retrospectively Evalumentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diagnosis Approach of Optic Neuritis

Francisco¹,

Lorena²

2015

J Neurol Neurophysiol

View full text Add to dashboard Cite

show abstract

Neuro-Ophthalmology Annual Review

Abstract: This review updates the comprehensive ophthalmologist on neuro-ophthalmic topics.

Cited by 1 publication

References 95 publications

Diagnosis Approach of Optic Neuritis

Diagnosis Approach of Optic Neuritis

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