Neuro-ophthalmological manifestations of sarcoidosis

Yates, William B.; McCluskey, Peter; Fraser, Clare L.

doi:10.1016/j.jneuroim.2022.577851

Cited by 7 publications

(10 citation statements)

References 42 publications

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“…Granulomatous vasculitis including sarcoidosis and Wegener’s granulomatosis was also found to be an independent risk factor for optic neuritis after adjusting for other confounders (adjusted OR: 18.28, 95% CI: 2.21–151.45, p = 0.0071). This finding is consistent with results of several previous studies which reports the association between optic neuritis and Wegener’s granulomatosis ( 10 , 18 – 20 ), or sarcoidosis ( 38 , 39 ). Sarcoidosis is a chronic multisystemic inflammatory disease that commonly affects the visual and neurological systems: the most common neuro-ophthalmic manifestation is optic neuropathy.…”

Section: Discussionsupporting

confidence: 93%

“…Optic neuritis has been considered as the most common manifestation of neuro-sarcoidosis ranging from 30 to 70% in a previous report ( 40 ). Sarcoid-related optic neuritis is an important differential diagnosis in typical demyelinating optic neuritis associated with multiple sclerosis and atypical optic neuritis, especially in the younger age group ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

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Association between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study

Jan,

Ho,

Sung

et al. 2024

Front. Neurol.

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PurposeOur study aimed to explore the correlation between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis.MethodsThis retrospective, nationwide, population-based, matched case–control investigation involved 33,190 individuals diagnosed with optic neuritis, identified using the International Classification of Diseases, Ninth Revision, Clinical Modification codes 377.30 for optic neuritis or 377.32 for retrobulbar neuritis. Patient data were extracted from the Taiwan National Health Insurance Research Database. Demographic characteristics, the presence of Sjögren syndrome, and pre-existing comorbid conditions were analyzed using univariate logistic regression. Continuous variables were assessed with a paired t-test. Adjusted logistic regression was employed to compare the prognosis odds ratio (OR) of patients with optic neuritis to controls.ResultsAfter adjusting for confounding variables, individuals with Sjögren syndrome exhibited a significantly higher likelihood of developing optic neuritis compared to controls (adjusted OR, 9.79; 95% confidence interval [CI], 7.28–12.98; p < 0.0001). Other conditions associated with increased odds of optic neuritis included rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, and granulomatous vasculitis (adjusted OR: 1.57, 95% CI: 1.33–1.86; adjusted OR: 2.02, 95% CI: 1.65–2.48; adjusted OR: 140.77, 95% CI: 35.02–565.85; adjusted OR: 2.38, 95% CI: 1.71–3.30; adjusted OR: 18.28, 95% CI: 2.21–151.45, respectively), as well as systemic infections such as human herpes viral infection and tuberculosis infection (adjusted OR: 1.50, 95% CI: 1.35–1.66; adjusted OR: 4.60, 95% CI: 3.81–5.56, respectively).DiscussionOur findings strongly support the existence of an association between Sjögren syndrome, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, granulomatous vasculitis, human herpes viral infection, tuberculosis, and optic neuritis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Association between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study

Jan,

Ho,

Sung

et al. 2024

Front. Neurol.

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“…The two abovementioned case reports describe patients with sarcoidosis complicated by optic neuritis. Neuro-sarcoidosis, a condition that affects up to 20% of sarcoidosis patients, can be found in any part of the central or peripheral nervous system and has important ophthalmic and neuro-ophthalmic manifestations [9][10][11]. Most commonly, sarcoidosis affects the uveal tract.…”

Section: Discussionmentioning

confidence: 99%

“…Typical clinical signs of optic neuritis associated with sarcoidosis include subacute or sudden onset of moderate to severe vision loss in the course of unilateral papilledema. Cranial MRI presents hyperintensity on T2 weighted images with contrast enhancement and the presence of granulomas along the optic nerve [10,12]. Due to unremarkable cranial CT scans, cerebral MRI in the first patient was not performed at the onset of the symptoms, hence there was no evaluation of the probable lesions on the optic nerve itself nor the sheath.…”

Section: Discussionmentioning

confidence: 99%

Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis

Zimna¹,

Szturmowicz²,

Sobiecka³

et al. 2023

Diagnostics

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Sarcoidosis is a systemic, granulomatous disease of unknown etiology, most often manifested by mediastinal and hilar lymph node enlargement and parenchymal nodules in the lungs. However, it may involve any other organ. Neuro-sarcoidosis, a condition that affects up to 20% of sarcoidosis patients, can be found in any part of the central or peripheral nervous system and has important ophthalmic and neuro-ophthalmic manifestations. We present two patients with sudden vision loss due to neurosarcoidosis. In both cases, biopsy of the mediastinal lymph node showed non-caseating granulomas consistent with sarcoidosis. Treatment involved high doses of methylprednisolone intravenously, followed by topical dexamethasone eye drops in the first case and a systemic steroid treatment in the second, resulting in symptom relief. Those two cases demonstrate that sarcoidosis should be considered as a differential diagnosis in cases of optic neuritis.

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“…Facial nerve paralysis can be unilateral or bilateral (simultaneous or sequential) and recurrent. Heerford's syndrome (parotiditis, fever, anterior uveitis, and peripheral nerve paralysis) is an uncommon manifestation of facial paralysis in sarcoidosis [11].…”

Section: Cranial Neuropathymentioning

confidence: 99%

Neurosarcoidosis: Review and Update of the Mimic Disease

Barbero Jimenez,

Rodríguez,

Barbero Jiménez

et al. 2023

SVOANE

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Sarcoidosis is a systemic inflammatory disorder characterized by non-caseating granulomas with variable involvement of the lungs, central nervous system (CNS), skin, liver, bone, and eye. Neurosarcoidosis is similarly heterogeneous with diverse anatomical manifestations and response to therapy. The diagnosis of neurosarcoidosis is established by the clinical syndrome, imaging and histopathological findings, and exclusion of other causes. In this narrative review, we summarize recent advances in the diagnosis and treatment of neurosarcoidosis.

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Neuro-ophthalmological manifestations of sarcoidosis

Cited by 7 publications

References 42 publications

Association between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study

Association between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study

Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis

Neurosarcoidosis: Review and Update of the Mimic Disease

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