Neuro-Ophthalmologic Manifestations of Systemic and Intracranial Disease

Brodsky, Michael C.

doi:10.1007/978-0-387-69069-8_11

Cited by 3 publications

(4 citation statements)

References 796 publications

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“…In general, posterior fossa tumors are more common than supratentorial tumors in children, although in infants the latter tend to be more frequent. 9 Consistent with this trend, in our series posterior fossa lesions were more common in older children and sellar/parasellar lesions were common in infants, although there were several older children with sellar/parasellar lesions [ Table 1 ].…”

Section: Discussionsupporting

confidence: 83%

Ophthalmic features of outpatient children diagnosed with intracranial space-occupying lesions by ophthalmologists

Alswaina¹,

Elkhamary²,

Shammari³

et al. 2015

Middle East Afr J Ophthalmol

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Introduction:Brain tumors in children often involve the visual system, but most retrospective series are by neurologists or oncologists. In this study we highlight the ophthalmic findings of outpatient children with visual complaints and/or strabismus who, based on ophthalmic examination, were suspected to and confirmed to harbor intracranial space-occupying lesions by magnetic resonance imaging (MRI).Materials and Methods:Retrospective case series of children (less than 18 years) who for visual complaints and/or strabismus underwent cranial MRI at a referral eye hospital (2005–2012), which revealed intracranial space-occupying lesions. Exclusion criteria were known preexisting orbital or ocular trauma, ocular tumor, or neurological disease.Results:For 26 patients (3 months-17 years; mean 7 years; median 9 years; and 14 boys), the most common clinical presentation was decreased vision with disc pallor (10) or swelling (three). Other presentations were strabismus with disc pallor or swelling (four; two of which were left sixth nerve palsies), acquired esotropia with diplopia (three; one bilateral and two left sixth nerve palsies), acquired exotropia (four; two of which were bilateral third nerve palsies, one of which was left partial third nerve palsy, and one of which was associated with headache), nystagmus (one), and disc swelling with headache (one). Most lesions were in the sellar/suprasellar space (10), posterior fossa (six), or optic nerve/chasm (four).Conclusions:The majority of outpatient children diagnosed by ophthalmologists with intracranial space-occupying lesions presented with disc swelling or pallor in the context of decreased vision or strabismus. Two strabismus profiles that did not include disc swelling or pallor were acquired sixth nerve palsy and acquired exotropia (with ptosis (third nerve palsy), nystagmus, or headache).

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Section: Discussionsupporting

confidence: 83%

Ophthalmic features of outpatient children diagnosed with intracranial space-occupying lesions by ophthalmologists

Alswaina¹,

Elkhamary²,

Shammari³

et al. 2015

Middle East Afr J Ophthalmol

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“…All these findings are comparable to the study on clinical presentation of supratentorial and infratentorial intracranial tumours in pediatric patients by Sánchez-Sánchez . [19] In older children, infratentorial tumours are more common than supratentorial tumours [4,20]. Consistent with the literature, in our series, 11 of 16 patients with posterior fossa tumours were older children.…”

Section: Discussionsupporting

confidence: 88%

“…In older children, infratentorial tumours are more common than supratentorial tumours [ 4 , 20 ]. Consistent with the literature, in our series, 11 of 16 patients with posterior fossa tumours were older children.…”

Section: Discussionmentioning

confidence: 99%

Neuroophthalmic Manifestations of Intracranial Tumours in Children

Kotecha

Gotecha

Chugh

et al. 2021

Case Reports in Ophthalmological Medicine

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Background. All children between 0 and 16 years presenting with brain tumours confirmed by Magnetic Resonance Imaging (MRI) and treated surgically in our institute were included in this study. Objective. The aim of this study is to evaluate the neuroophthalmic and clinical characteristics of intracranial space occupying lesions in children. Methods. Neuroophthalmic manifestations along with location of the tumour by contrast-enhanced MRI, type of surgical intervention, and postoperative histopathological diagnosis were evaluated. Results. In pediatric brain tumours, male preponderance was seen and supratentorial location was more common in general, while in older children, infratentorial tumours were more common than supratentorial tumours. Headache, vomiting, and cerebellar signs were the commonest neurological features. Diminution of vision, diplopia, and strabismus were the commonest ophthalmic symptoms. Papilledema, ophthalmoparesis, and nystagmus were the most frequent ophthalmological signs. Neurological manifestations of seizures, altered sensorium and motor deficits were more frequently seen in supratentorial tumours, while cranial nerve involvement and ataxia were seen in infratentorial tumours. Ophthalmological manifestations including diplopia, strabismus, ophthalmoparesis, and nystagmus were more frequently seen in infratentorial tumours. Astrocytoma was the most frequent histopathological diagnosis followed by medulloblastoma. Conclusion. Diagnosis of pediatric intracranial tumours is complex and requires a multidisciplinary approach for prompt management. An ophthalmologist should have a high index of suspicion for brain tumours especially in patients presenting with common ocular symptoms like diminution of vision, diplopia, and strabismus without any neurological symptoms.

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“…1 Reported ophthalmological features include conjunctival, retinal, choroidal, and orbital varicosities, secondary glaucoma, iris coloboma and heterochromia, and several neuro-ophthalmic manifestations, including strabismus. 3,4 To our knowledge, lymphangiectasia of the conjunctiva has not been reported in association with KTWS.…”

mentioning

confidence: 84%

Bilateral Conjunctival Lymphangiectasia in Klippel-Trénaunay-Weber Syndrome

Belliveau¹

2009

Arch Ophthalmol

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Bilateral Conjunctival Lymphangiectasia in Klippel-Trénaunay-Weber Syndrome K lippel-Trénaunay-Weber syndrome (KTWS) is a rare congenital malformation syndrome involving blood and lymphatic vessels as well as disturbed growth of soft tissues and bone. 1 The clinical features can be extremely variable, but most patients exhibit the triad of cutaneous capillary malformation, varicose veins, and hypertrophy of bone and soft tissue. 2 Thromboembolic events occur at an increased rate and may be fatal. 2 Most cases of KTWS are sporadic and no causative gene or etiology has been firmly established. 1 Reported ophthalmological features include conjunctival, retinal, choroidal, and orbital varicosities, secondary glaucoma, iris coloboma and heterochromia, and several neuro-ophthalmic manifestations, including strabismus. 3,4 To our knowledge, lymphangiectasia of the conjunctiva has not been reported in association with KTWS.

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Neuro-Ophthalmologic Manifestations of Systemic and Intracranial Disease

Cited by 3 publications

References 796 publications

Ophthalmic features of outpatient children diagnosed with intracranial space-occupying lesions by ophthalmologists

Ophthalmic features of outpatient children diagnosed with intracranial space-occupying lesions by ophthalmologists

Neuroophthalmic Manifestations of Intracranial Tumours in Children

Bilateral Conjunctival Lymphangiectasia in Klippel-Trénaunay-Weber Syndrome

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