Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 and Its Vaccination: A Narrative Review

Feizi, Mohadeseh; Isen, Danielle R; Tavakoli, Mehdi

doi:10.18502/jovr.v18i1.12731

Cited by 5 publications

(10 citation statements)

References 89 publications

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“…Tonic pupils or Horner syndrome were also noted as a neuro-ophthalmic manifestation in 4 patients with COVID-19 123–127 . Tonic pupils were reported to develop after COVID-19 infection with sluggish pupillary reaction to light with vermiform movement and segmental constriction.…”

Section: Neuro-ophthalmic Manifestationsmentioning

confidence: 99%

“…Tonic pupils or Horner syndrome were also noted as a neuro-ophthalmic manifestation in 4 patients with COVID-19. [123][124][125][126][127] Tonic pupils were reported to develop after COVID-19 infection with sluggish pupillary reaction to light with vermiform movement and segmental constriction. Notably, near response was also impaired in reported cases of tonic pupils contrary to the typical presentation in noninfectious cases, 123,124 and the diagnosis was confirmed by hypersensitivity to 0.1% pilocarpine with pupillary constriction in the affected eyes.…”

Section: Pupillary Abnormalitiesmentioning

confidence: 99%

See 1 more Smart Citation

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Lin,

Sen,

Gupta

et al. 2023

Asia-Pacific Journal of Ophthalmology

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The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 was one of the most devastating public health issues in recent decades. The ophthalmology community is as concerned about the COVID-19 pandemic as the global public health community is, as COVID-19 was recognized to affect multiple organs in the human body, including the eyes, early in the course of the outbreak. Ophthalmic manifestations of COVID-19 are highly variable and could range from mild ocular surface abnormalities to potentially sight and life-threatening orbital and neuro-ophthalmic diseases. Furthermore, ophthalmic manifestations may also be the presenting or the only findings in COVID-19 infections. Meanwhile, global vaccination campaigns to attain herd immunity in different populations are the major strategy to mitigate the pandemic. As novel vaccinations against COVID-19 emerged, so were reports on adverse ophthalmic reactions potentially related to such. As the world enters a post-pandemic state where COVID-19 continues to exist and evolve as an endemic globally, the ophthalmology community ought to be aware of and keep abreast of the latest knowledge of ophthalmic associations with COVID-19 and its vaccinations. This review is a summary of the latest literature on the ophthalmic manifestations of COVID-19 and the adverse ophthalmic reactions related to its vaccinations.

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Section: Neuro-ophthalmic Manifestationsmentioning

confidence: 99%

Section: Pupillary Abnormalitiesmentioning

confidence: 99%

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Lin,

Sen,

Gupta

et al. 2023

Asia-Pacific Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…In these cases, patients were reported to develop a gradual loss of vision one to two weeks after severe COVID infection unilaterally or bilaterally; females tended to suffer from ON and retinal complications. [ 56 , 57 , 63 ]…”

Section: Introductionmentioning

confidence: 99%

Acute Optic Neuritis: An Update on Approach and Management

Jamali Dogahe,

Pakravan,

Pakravan

2023

JOVR

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This review discusses the physical examination and diagnostic tests necessary to diagnose optic neuritis (ON) and provides an update on the approach and management of acute ON. A comprehensive search of the PubMed database was conducted, limited to English-language journals and recent publications. A total of 160 articles were initially screened by title, of which 73 articles were included in the narrative synthesis. ON is an inflammation of the optic nerve that can be caused by different systemic and neurological disorders. It is commonly presented as a subacute unilateral painful vision loss, and based on its clinical manifestation, it can be classified as typical or atypical. Atypical ON is bilateral with visual acuity of worse than 20/200 or has an atypical demographic presentation for demyelination, such as a non-Caucasian male with optic disc swelling, for which neuromyelitis optica spectrum disorder (NMOSD), myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD), or other etiologies should be considered. Steroids and immunosuppressants are the main treatment options for ON, and timely treatment initiation is critical to preventing irreversible vision loss, especially in atypical cases.

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“…

We read with interest the narrative review by Feizi et al about the neuro-ophthalmologic complications of SARS-CoV-2 infections and vaccinations. [1] It was concluded that SARS-CoV-2 infections and all SARS-CoV-2 vaccines can affect the afferent and efferent visual pathways due to papillophlebitis, idiopathic intracranial, hypertension, optic neuritis, ischemic stroke, pupillomotor pathway impairment, and cranial nerve dysfunction. [1] The study is comprehensive, but has limitations that are a cause for concern and should be discussed.Headaches should not always be classified as the neuro-ophthalmologic manifestation of SARS-CoV-2 infections or vaccinations.

…”

mentioning

confidence: 99%

“…[1] It was concluded that SARS-CoV-2 infections and all SARS-CoV-2 vaccines can affect the afferent and efferent visual pathways due to papillophlebitis, idiopathic intracranial, hypertension, optic neuritis, ischemic stroke, pupillomotor pathway impairment, and cranial nerve dysfunction. [1] The study is comprehensive, but has limitations that are a cause for concern and should be discussed.Headaches should not always be classified as the neuro-ophthalmologic manifestation of SARS-CoV-2 infections or vaccinations. Headache, though regarded as one of the most common…”

mentioning

confidence: 99%