Neuro-Ophthalmic Complications of COVID-19 Infection and Vaccination

Alotaibi, Kholoud; Badeeb, Nooran; Karanjia, Rustum

doi:10.1016/j.yaoo.2023.03.004

Cited by 3 publications

(1 citation statement)

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“…Several individual case reports of optic neuritis following COVID-19 vaccination have been published in the literature, with optic neuritis being considered the most commonly reported neuro-ophthalmic event following COVID-19 vaccination. [25][26][27][28] Jaffrey et al calculated the reporting rates of optic neuritis, collecting cases from the Vaccine Adverse Event Reporting System, and divided them into the pre-pandemic, COVID-19 pandemic and COVID-19 vaccine periods. 28 The authors showed no significant increase in the reporting rate of optic neuritis following COVID-19 vaccination when compared with the range of incidence in the general population.…”

Section: Discussionmentioning

confidence: 99%

Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK

Testi,

Soomro,

Pavesio

et al. 2023

Br J Ophthalmol

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Background/aimsThe UK Medicines and Healthcare products Regulatory Agency (MHRA) has published suspected adverse drug reactions to vaccines against COVID-19. Ocular inflammatory events following COVID-19 vaccination have been reported worldwide.MethodsWe analysed MHRA data on spontaneous reports of suspected ocular inflammatory events following COVID-19 vaccination between January 2021 and September 2022.ResultsThe MHRA received 300 UK spontaneous suspected reports of ocular inflammatory events following COVID-19 vaccination, with a calculated prevalence of 6.6 events per 1 000 000 vaccinated individuals. Anterior uveitis was the most common phenotype (58.3%), followed by optic neuritis in 39.3%. Median number of days between vaccination and onset was 8 days. Resolution of the event was seen in 52.3%.ConclusionOcular inflammatory events following COVID-19 vaccination have a very rare prevalence in the UK. There is no increase in the reporting rate of uveitis, optic neuritis and scleritis following COVID-19 vaccination when compared with the range of incidence in the UK population. The Yellow Card System represents a vital instrument within the domain of pharmacovigilance, empowering patients and healthcare professionals to contribute to the ongoing monitoring of medication safety.

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