Neuro-Insular Complexes in the Human Pancreas

Krivova, Yuliya; Proshchina, Alexandra; Barabanov, V. M.; Saveliev, S. V.

doi:10.5772/65059

Cited by 3 publications

(5 citation statements)

References 60 publications

(116 reference statements)

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“…The density of NIC distribution also gradually decreases at birth. Our quantitative data indicate that the largest number of NIC I was observed in the early and middle foetal periods, during the active morphogenesis of pancreatic islets, whereas at birth (in the late foetal period) and in the adult, NIC II became more prevalent [91]. During the middle and late foetal periods, the nervous system components also contact epithelial cells located in ducts or in clusters outside the ductal epithelium and form complexes with separate epithelial cells.…”

Section: Autonomic Nervous Systemmentioning

confidence: 76%

“…Already in the early foetal period, it was possible to identify NIC I (single insulin-or glucagon-containing cells in ganglia ( Supplementary Video 1) or ganglia associated with the islets) and NIC II (single endocrine cells in the nerve (Supplementary Video 2), nerve endings associated with single endocrine cells or with the islets) and make their 3D reconstruction. The analysis of three-dimensional reconstructions allowed us to show ganglia associated with two islets at once, islets associated simultaneously with two ganglia, and NIC of mixed (intermediate) type [91]. Moreover, in the foetal pancreas, starting from 13 weeks, we showed simultaneously neuro-insular complexes and contacts between the structures of nervous system and epithelial cells located in ducts as well as in cell clusters that were often connected with the ducts.…”

Section: Autonomic Nervous Systemmentioning

confidence: 88%

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Development of Human Pancreatic Innervation

Proshchina¹,

Krivova²,

Леонова³

et al. 2018

Autonomic Nervous System

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Human pancreatic innervation is of particular interest due to its possible role in the pathogenesis of such diseases as diabetes mellitus, pancreatitis and pancreatic cancer. Despite the clinical importance, data concerning pancreatic innervation during human ontogeny and in various disorders are very limited. In this chapter, we present a review on human pancreatic autonomic innervation on the basis of the literature data and our previous results. Special attention is paid to the innervation of the endocrine pancreas. Gradual branching of neural network was seen during human pancreatic development. Innervation of the foetal pancreas is more abundant than in adults. In agreement with previous observations, we have revealed a close integration and similarity between endocrine cells and nervous elements in the developing human pancreas. Moreover, simultaneous interactions between the nervous system components, epithelial cells and endocrine cells were detected in the pancreas during prenatal human development. It has been suggested that pancreatic innervation plays an important role not only in regulation of endocrine and exocrine activity but also in normal islet morphogenesis.

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Section: Autonomic Nervous Systemmentioning

confidence: 76%

Section: Autonomic Nervous Systemmentioning

confidence: 88%

Development of Human Pancreatic Innervation

Proshchina¹,

Krivova²,

Леонова³

et al. 2018

Autonomic Nervous System

Self Cite

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“…In the human foetal pancreas, epithelial ductal cells express numerous transcription factors that regulate endocrine cell differentiation [19]. tem may be for the migration of epithelial progenitors into creative islets [21] and that the nervous system directly regulates the weight of endocrine cells and their maturation.…”

Section: Discussionmentioning

confidence: 99%

“…In the foetal life, their stem cells are located in the epithelium of the pancreatic ductuli[15]. K i r o v o v a et al[21] demonstrated close integration between nervous system structures and endocrine cells in the human pancreas. As previously emphasized during the prenatal development of the pancreas, the nervous system regulates the proliferation and maturation of endocrine cells and contributes to the formation of islet architecture.…”

mentioning

confidence: 99%

Localisation of S100 Protein and Acetylated Tubulin in Sheep Pancreas

Marettová

Maretta

2021

Folia Veterinaria

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The pancreas plays a critical role in the control of nutritional homeostasis. It consists of two major parts, the exocrine pancreas, and the endocrine pancreas. In the present study S100 protein and acetylated α-tubulin were used to identify positive structures in both the exocrine and endocrine part of the ovine pancreas. In the exocrine part of the pancreas, a positive reaction to S100 protein was confined to centroacinar cells, intercalated, and intralobular ducts cells. In addition, the S100 protein was localized in the Schwann cells of nerve fibres. On the pancreatic islets, the S100 protein has been observed in Schwann cells of nerve axons, where they form a fine envelope that invests the islet surface. Inside the pancreatic islets, the Schwann cells positive for S100 protein envelope the endocrine cells of the islets. The difference in positivity of the S100 protein was found in relation to the endocrine cells. The relationship between endocrine cell positivity and positive exocrine duct cells was discussed. Acetylated α-tubulin (AT) was restricted to axons of the nerve fibres and was located within the connective tissue accompanying intralobular and inter-lobular ducts, and between secretory acini in close contact with secretory cells.

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“…Islet innervation starts at 12 weeks. Moreover, so-called neuro-insular complexes may be detected in the developing human pancreas starting at this time [59]. However, Jeon et al [8] have shown that large pancreatic islets of the mixed type, typical in adults, are formed only after 21 weeks of development.…”

Section: Prenatal Development Of the Human Pancreasmentioning

confidence: 97%

Ontogeny of the Human Pancreas

Proshchina¹,

Krivova²,

Гуревич³

et al. 2019

Comparative Endocrinology of Animals

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Pancreatic disorders are the most common pathologies in humans worldwide. Detailed information on pancreatic cytoarchitecture, vascularisation, innervation, morphogenesis, and cell differentiation is required for the development of new approaches to the treatment of these diseases. Currently, the majority of studies on pancreas development are performed on experimental animals (mainly rodents). Studies on human pancreatic prenatal development are restricted in number by ethical constraints and some technical difficulties. However, interspecies differences in pancreatic structure and development are considerable. Therefore, data obtained in experiments on animals and cell cultures must be supplemented with information obtained directly from human pancreatic autopsies. In this chapter, we summarise our previous results and the literature data on human pancreatic ontogeny. Special attention has been paid to the endocrine pancreas, which undergoes morphogenetic restructuring during human development. Several forms of structural organisation of the endocrine pancreas (single endocrine cells, small clusters of endocrine cells, mantle, bipolar, and mosaic islets) gradually appear during development. It is important that this restructuring is accompanied by changes in the ratio of pancreatic endocrine cells. The mechanisms of these changes are still unclear. The difficulties in identifying progenitor cells and tracking cell differentiation are the main problems associated with this issue.

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Neuro-Insular Complexes in the Human Pancreas

Cited by 3 publications

References 60 publications

Development of Human Pancreatic Innervation

Development of Human Pancreatic Innervation

Localisation of S100 Protein and Acetylated Tubulin in Sheep Pancreas

Ontogeny of the Human Pancreas

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