Neuro-immune Interactions in the Tissues

Chu, Coco; Artis, David; Chiu, Isaac M.

doi:10.1016/j.immuni.2020.02.017

Cited by 171 publications

(117 citation statements)

References 97 publications

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“…Several neuropeptides and neurotransmitters have been shown to govern immunological functions through discrete subsets of immune cells [228]. SP, a highly conserved neuropeptide that mediates ENS signaling as well as immune cell proliferation and cytokine production, is elevated in IBD and there is evidence of increased numbers of SP-positive neurons in the myenteric plexus of UC patients [229][230][231].…”

Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

The enteric nervous system in gastrointestinal disease etiology

Holland

Bon-Frauches

Keszthelyi

et al. 2021

Cell. Mol. Life Sci.

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A highly conserved but convoluted network of neurons and glial cells, the enteric nervous system (ENS), is positioned along the wall of the gut to coordinate digestive processes and gastrointestinal homeostasis. Because ENS components are in charge of the autonomous regulation of gut function, it is inevitable that their dysfunction is central to the pathophysiology and symptom generation of gastrointestinal disease. While for neurodevelopmental disorders such as Hirschsprung, ENS pathogenesis appears to be clear-cut, the role for impaired ENS activity in the etiology of other gastrointestinal disorders is less established and is often deemed secondary to other insults like intestinal inflammation. However, mounting experimental evidence in recent years indicates that gastrointestinal homeostasis hinges on multifaceted connections between the ENS, and other cellular networks such as the intestinal epithelium, the immune system, and the intestinal microbiome. Derangement of these interactions could underlie gastrointestinal disease onset and elicit variable degrees of abnormal gut function, pinpointing, perhaps unexpectedly, the ENS as a diligent participant in idiopathic but also in inflammatory and cancerous diseases of the gut. In this review, we discuss the latest evidence on the role of the ENS in the pathogenesis of enteric neuropathies, disorders of gut–brain interaction, inflammatory bowel diseases, and colorectal cancer.

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Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

The enteric nervous system in gastrointestinal disease etiology

Holland

Bon-Frauches

Keszthelyi

et al. 2021

Cell. Mol. Life Sci.

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“…As a particular subset of primary sensory neurons, nociceptors can respond to pain stimuli and subsequently convert the stimuli into nerve impulses to inform brain to produce the sensation of pain ( 31 ). Once receiving the stimuli, nociceptors can regulate the immune cell response activity at the tissue by releasing neuropeptides which were stored at the dense-core vesicles both in nociceptors’ synaptic terminals at the CNS and in the nerve endings within the peripheral tissues ( 32 ). The transducers of noxious stimuli are voltage-gated and ligand-gated ion channels expressed on the nociceptor nerve terminals, such as transient receptor potential vanilloid subfamily member 1 (TRPV1), transient receptor potential ankyrin 1 (TRPA1), Nav (Voltage-gated sodium channels)1.7, Nav1.8, and Nav1.9 ( 33 ).…”

Section: γδ T Cells Interact With the Peripheral Nervous Systemmentioning

confidence: 99%

γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde

Zhang

Zeng

2021

Front. Immunol.

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γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance. Recently, accumulating researches have highlighted the crosstalk between γδ T cells and nervous systems. In these reports, γδ T cells maintain some physiological functions of central nervous system by secreting interleukin (IL) 17, and neurons like nociceptors can in turn regulate the activity of γδ T cells. Moreover, γδ T cells are involved in neuroinflammation such as stroke and multiple sclerosis. This review illustrates the relationship between γδ T cells and nervous systems in physiological and pathological conditions.

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“…Most recently, Teratani et al reported the biological mechanism by which bacterial information from the intestinal tract is integrated in the liver and transmitted to the brain to control the production of intestinal regulatory T cells through the vagal nerve reflex [73]. Thus, several experimental approaches have been reported on autonomic innervation of immune organs and neuroimmune modulation [74].…”

Section: Gut Dysbiosis In Agidmentioning

confidence: 99%

Autoimmune gastrointestinal dysmotility: the interface between clinical immunology and neurogastroenterology

Nakane

Mukaino

Ihara

et al. 2020

Immunological Medicine

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Autoimmune gastrointestinal dysmotility (AGID), an idiopathic or paraneoplastic phenomenon, is a clinical form of limited autoimmune dysautonomia. The symptoms of AGID and gastrointestinal manifestations in patients with autoimmune rheumatic diseases are overlapping. Antineuronal autoantibodies are often detected in patients with AGID. Autoantibodies play a key role in GI dysmotility; however, whether they cause neuronal destruction is unknown. Hence, the connection between the presence of these autoantibodies and the specific interference in synaptic transmission in the plexus ganglia of the enteric nervous system has to be determined. The treatment options for AGID are not well-defined. However, theoretically, immunomodulatory therapies have been shown to be effective and are therefore used as the first line of treatment. Nonetheless, diverse combined immunomodulatory therapies should be considered for intractable cases of AGID. We recommend comprehensive autoimmune evaluation and cancer screening for clinical diagnosis of AGID. Univocal diagnostic criteria, treatment protocols, and outcome definitions for AGID are required for prompt diagnosis and treatment and appropriate management of immunotherapy, which will circumvent the need for surgeries and improve patient outcome. In conclusion, AGID, a disease at the interface of clinical immunology and neurogastroenterology, requires further investigations and warrants cooperation among specialists, especially clinical immunologists, gastroenterologists, and neurologists.

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Neuro-immune Interactions in the Tissues

Cited by 171 publications

References 97 publications

The enteric nervous system in gastrointestinal disease etiology

The enteric nervous system in gastrointestinal disease etiology

γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde

Autoimmune gastrointestinal dysmotility: the interface between clinical immunology and neurogastroenterology

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