Neuro‐immune interactions and the role of Mas‐related G protein‐coupled receptors in the gastrointestinal tract

Abstract

Over the past decade, the research field dealing with the role of a new family of Rhodopsin A-like G protein-coupled receptors, that is, the family of Mas-related G protein-coupled receptors (Mrgprs) has expanded enormously. A plethora of recent studies have provided evidence that Mrgprs are key players in itch and pain, as well as in the initiation and modulation of inflammatory/allergic responses in the skin. Over the years, it has become clear that this role is not limited to the skin, but extends to other mucosal surfaces such as the respiratory tract and the gastrointestinal (GI) tract. In the GI tract, Mrgprs have emerged as novel interoceptive sensory pathways linked to health and disease, and are in close functional association with the gut's immune system. This review aims to provide an update of our current knowledge on the expression, distribution and function of members of this Mrgpr family in intrinsic and extrinsic neuro-immune pathways related to the GI system.

Renin-Angiotensin System: Updated Understanding and Role in Physiological and Pathophysiological States

“…MrgD is widely expressed in the central nervous system, heart, kidney, sensory neurons of dorsal root and trigeminal ganglia, gastrointestinal tract, respiratory tract, and skin [159][160][161][162]. However, the downstream effects of MrgD remain to be elucidated.…”

Expanding understanding of the autonomic nervous system with a dash of Flemish charm, Belgian beer, and unrelenting camaraderie: The Anatomical Record raises a glass to J‐P Timmermans

“…Following the halcyon days of John Ladman, J‐P's wisdom was shared with EIC's Roger Markwald, co‐author Kurt Albertine, and co‐author Heather Smith. J‐P's scholarly excellence has also regularly graced the pages of our journal (he has been a frequent author reporting his own novel science and served as Guest Editor for Anatomical Record Special and Thematic Paper Issues; e.g., Abdellah et al, 2018; Adriaensen et al, 2003; Alpaerts et al, 2015; Bagyanszki et al, 2010; Geerts et al, 2008; Klimaschewski & Timmermans, 2019; Scheuerman et al, 1989; Timmermans & Geertz, 2005; Timmermans, Hens, & Adriaensen, 2001; Timmermans, Markwald, & Litke, 2001, 2003; Van Remoortel et al, 2023). We are most appreciative of his heartfelt efforts and support.…”

From anatomy to immunity in the gastrointestinal system

“…The article by van Remoortel et al (2022) gives a fascinating view about recent concepts on the functions of Mas‐related G protein‐coupled receptors (Mrgprs) in the gastrointestinal tract. Initially discovered in the spine and trigeminal ganglia, thus associated with neural pathways involved in itch and nociception, it is clear today that Mrgprs constitute a large family with multiple members and widespread tissue expression, potentially supporting a wide array of important functions that have only started to emerge.…”