2003
DOI: 10.1016/s1471-4906(03)00002-4
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Neuro-immune connections: evidence for a neuro-immunological synapse

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Cited by 28 publications
(28 citation statements)
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“…Functionally, neurotransmitters including catecholamines and acetylcholine as well as neuropeptides including calcitonin gene-related peptide, vasoactive intestinal peptide, somatostatin, substance P, and pro-opiomelanocortin-derived peptides have been shown to modulate immune and inflammatory responses (54). Furthermore, evidence indicates that direct innervations may control immune responses (55), and the term "neuroimmunological synapse" has been proposed for contacts between neurons and APCs (56). Langerhans cells, a subtype of DC that were originally thought to originate in the nervous system because of their close contacts with nerve fibers (57), have recently been linked closely to calcitonin gene-related peptide/substance P-containing fibers in the skin (presumably nociceptive neurons) of humans (58 -60), primates (58), and rodents (58,61) as well as in the viscera (62).…”
Section: Discussionmentioning
confidence: 99%
“…Functionally, neurotransmitters including catecholamines and acetylcholine as well as neuropeptides including calcitonin gene-related peptide, vasoactive intestinal peptide, somatostatin, substance P, and pro-opiomelanocortin-derived peptides have been shown to modulate immune and inflammatory responses (54). Furthermore, evidence indicates that direct innervations may control immune responses (55), and the term "neuroimmunological synapse" has been proposed for contacts between neurons and APCs (56). Langerhans cells, a subtype of DC that were originally thought to originate in the nervous system because of their close contacts with nerve fibers (57), have recently been linked closely to calcitonin gene-related peptide/substance P-containing fibers in the skin (presumably nociceptive neurons) of humans (58 -60), primates (58), and rodents (58,61) as well as in the viscera (62).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, recent study suggested that the expression of Muscarinic Acetylcholine receptor M2 on dendritic cells could provide a way of prion neuroinvasion [33]. Neuroimmune synapses were suspected since a long time [49], but little proof was presented. Our study shows connections between dendritic cells and nerve endings or nerve fibres in lymphoid organs.…”
Section: Discussionmentioning
confidence: 99%
“…8B). Anyway, very recently evidence for a neuro-immunological synapse [34] and a virological synapse [35] emerged.…”
mentioning
confidence: 99%