Neurenteric cysts in children: 16 consecutive cases and review of the literature

Oliveira, Ricardo Santos de; Cinalli, Giuseppe; Roujeau, Thomas; Sainte‐Rose, Christian; Pierre-Kahn, Alain; Zérah, Michel

doi:10.3171/ped.2005.103.6.0512

Cited by 87 publications

(139 citation statements)

References 90 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…18 Of the neurenteric cysts described in the literature, about 50% are lined with gastrointestinal epithelium, and 17% with ciliated respiratory epithelium, while the remaining cysts share mixed characteristics of the above types and also may contain pancreatic or squamous epithelium. 7,8,12,13,15 Immunohistochemically, neurenteric cysts are known to stain positively for carcinoembryonic an ti gen, cytokeratin, and epithelial membrane antigen, while staining negatively for glial fibrillary acidic protein, neu ron-specific enolase, and vimentin; these features are con sistent with an endodermal, rather than ectodermal, origin of the cyst wall epithelium. 6,12,13,15 In the present case, the cyst displayed features of a mucin-secreting, respiratory-type epithelium in addition to squamous features.…”

Section: Discussionmentioning

confidence: 99%

“…13 To our knowledge, only 26 cases of intracranial neurenteric cysts, including the present case, have been identified in patients 18 years of age or younger (Table 1). 5,[8][9][10]12,14,16,17,20,21,[23][24][25][27][28][29][30][32][33][34] All of the pediatric cases previously reported in the literature involved children who presented with unilateral neurenteric cysts. Of the 25 patients, 10 were male and 15 were female; the patients' mean age was 7.27 years (range 1 day-18 years).…”

Section: Discussionmentioning

confidence: 99%

“…2,3,6 Although these lesions may occur anywhere in the central nervous system and represent 0.01% of all central nervous system tumors, they are most commonly located in the spine, particularly in the lower cervical and upper thoracic regions, and make up 0.3%-0.5% of all spinal tumors. [1][2][3]7,8 Intracranial neurenteric cysts are exceptionally rare and represent only about 10%-17.9% of all neurenteric cysts. 31 According to a recent (2012) review by Gauden et al, 13 only 140 patients with intracranial neurenteric cysts have been reported in the literature since 1952.…”

Section: ©Aans 2013mentioning

confidence: 99%

See 2 more Smart Citations

Staged bilateral far-lateral approach for bilateral cervicomedullary junction neurenteric cysts in a 10-year-old girl

Patel

Liu²

2013

PED

View full text Add to dashboard Cite

Neurenteric cysts are rare and benign lesions that consist of ectopic alimentary tissue residing in the central nervous system. They tend to occur most frequently in an intraspinal rather than intracranial location. Intracranial neurenteric cysts are a rare occurrence in the pediatric population. These lesions typically present as unilateral cystic structures in the lower cerebellopontine angle and craniocervical junction. To the authors' knowledge, there have been no reported cases of bilateral localization of intracranial neurenteric cysts. In this report, they present an unusual case of a 10-year-old girl who was found to have bilateral intracranial neurenteric cysts at the pontomedullary junction. The patient was successfully treated with staged, bilateral far-lateral transcondylar resection of the cysts. The authors also provide a brief overview of the literature describing intracranial neurenteric cysts in children.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: ©Aans 2013mentioning

confidence: 99%

See 1 more Smart Citation

Staged bilateral far-lateral approach for bilateral cervicomedullary junction neurenteric cysts in a 10-year-old girl

Patel

Liu²

2013

PED

View full text Add to dashboard Cite

show abstract

“…Most intraspinal NECs are localized in the intradural extramedullary (IDEM) compartment of the cervicothoracic junction and are associated with bone, soft-tissue, and visceral abnormalities. 10,17,26 However, NECs rarely occur in an intramedullary location, and intramedullary NECs represent < 5% of intraspinal NECs. 22 To our knowledge, only 38 cases of NEC (with or without concurrent malformations) have been described since the publication of the earliest report in 1954.…”

mentioning

confidence: 99%

“…22 To our knowledge, only 38 cases of NEC (with or without concurrent malformations) have been described since the publication of the earliest report in 1954. [2][3][4]8,10,[12][13][14]16,[18][19][20][21][22][24][25][26][27][29][30][31][32][33][34][35][37][38][39][40][41][42]44,45 Most previous publications regarding intramedullary NECs have been case reports. Therefore, the optimal management for this lesion has not been fully determined.…”

mentioning

confidence: 99%

Clinical presentation and surgical outcomes of intramedullary neurenteric cysts

Yang¹,

Wu²,

Fang

et al. 2015

SPI

View full text Add to dashboard Cite

OBJECT Intramedullary neurenteric cysts (NECs) are exceedingly rare lesions and have been previously reported in case reports. The aim of this study was to determine the clinical manifestations, radiological features, and long-term prognosis of patients with such lesions. METHODS The authors retrospectively reviewed the records of 13 patients with an intramedullary NEC. Each patient underwent MRI, laminotomy, and microsurgery. The accurate diagnosis was based on imaging and pathology findings. Each patient's follow-up status was determined through individual office visits and a structured telephone interview. RESULTS The series included 7 male and 6 female patients. Progressive or intermittent motor deficit was the main symptom associated with or without pain or sensory disturbance. Five cysts were located in the cervical cord, 1 in the cervicothoracic cord, 3 in the thoracic cord, and 4 in the conus medullaris. Concurrent malformations included scoliosis (3 cases), fusion of rib (1 case), enlarged spinal canal (1 case), tethered spinal cord (1 case), and ectocardia (1 case). Gross-total resection of the cyst was achieved in 8 cases, and subtotal resection (STR) was achieved in 5 cases. All patients were followed up, with a mean duration of 66.5 months. Cyst recurrence was observed in 4 cases after STR. In 2 cases the patients underwent reoperation; the other 2 patients remained clinically stable and did not undergo reoperation. At the last evaluation, neurological function was improved in 11 patients and remained stable in 2 patients. CONCLUSIONS Intramedullary NECs should be considered in the differential diagnosis of a middle-aged patient with intermittent neurological symptoms and concurrent malformations. Early surgery is advocated to prevent permanent neurological deficits. When gross-total resection cannot be achieved, maximally safe removal under the protection of intraoperative neuromonitoring is advised. Because of the high risk of cyst recurrence, routine follow-up MRI is needed. If a residual cyst shows obvious regrowth and results in neurological deficits, timely reoperation with a goal of STR should be performed.

show abstract

The role of clofarabine in hematologic and solid malignancies—Development of a next‐generation nucleoside analog

Faderl

Gandhi

Keating

et al. 2005

Cancer

View full text Add to dashboard Cite

Clofarabine is a new-generation nucleoside analog that has been synthesized to combine the most favorable pharmacokinetic properties of its congeners fludarabine and cladribine. In addition to inhibition of DNA polymerases and DNA synthesis, clofarabine acts as a strong inhibitor of ribonucleotide reductase (RnR), an enzyme involved in regulating intracellular deoxynucleotide pools, and has a high affinity to the enzyme deoxycytidine kinase (dCyd), the rate-limiting step in nucleoside phosphorylation.A review of the English literature was performed that included original articles and related reviews from the MEDLINE (PubMed) data base and from abstracts based on the publication of meeting materials.Although it was synthesized early in the 1980s, the development of clofarabine was stalled until

show abstract

Neurenteric cysts in children: 16 consecutive cases and review of the literature

Cited by 87 publications

References 90 publications

Staged bilateral far-lateral approach for bilateral cervicomedullary junction neurenteric cysts in a 10-year-old girl

Staged bilateral far-lateral approach for bilateral cervicomedullary junction neurenteric cysts in a 10-year-old girl

Clinical presentation and surgical outcomes of intramedullary neurenteric cysts

The role of clofarabine in hematologic and solid malignancies—Development of a next‐generation nucleoside analog

Contact Info

Product

Resources

About