Neuregulins

Seroogy, Kim B.; Dickerson, Jonathan W.; Cassella, Sarah N.; Zhang-Auberson, Lixin

doi:10.1016/b978-0-12-385095-9.00223-2

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…The Nrg1 gene has many splice variants that encode functionally distinct proteins across a variety of cell types 61 . Type I Nrg1 is upregulated within SCs after injury 62 , raising the question of how this factor could be a signal of axon damage that controls Mitf localization?…”

Section: Discussionmentioning

confidence: 99%

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Daboussi

Costaguta

Gullo

et al. 2022

Preprint

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Schwann cells respond to acute axon damage by transiently transdifferentiating into specialized repair cells that restore sensorimotor function. However, the molecular systems controlling repair cell formation and function are not well defined and consequently it is unclear whether this form of cellular plasticity has a role in peripheral neuropathies. Here we identify Mitf as a transcriptional sensor of axon damage under the control of Nrg-ErbB-PI3K-PI5K-mTorc2 signaling. Mitf regulates a core transcriptional program for generating functional repair Schwann cells following injury and during peripheral neuropathies caused by CMT4J and CMT4D. In the absence of Mitf, core genes for epithelial-to-mesenchymal transition, metabolism and dedifferentiation are misexpressed and nerve repair is disrupted. Taken together, our findings demonstrate that Schwann cells monitor axonal health using a phosphoinositide signaling system that controls Mitf, which is critical for activating cellular plasticity and counteracting neural disease.

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Section: Discussionmentioning

confidence: 99%

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Daboussi

Costaguta

Gullo

et al. 2022

Preprint

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“…Hence, this EGF-like domain is both necessary and sufficient for the biological activity of NRG proteins. The alternative splice variants of this domain give rise to α/β transcripts [ 82 ].…”

Section: Neuregulins Ggf2 and Future Therapeutic Perspectives For Pos...mentioning

confidence: 99%

“…The expression and emerging neurotrophic, neuroprotective, and neuromodulatory roles of NRGs in the central nervous system are well documented [ 82 ]. Multiple experimental investigations, focusing especially on central nervous system degenerative diseases, such as multiple sclerosis or Alzheimer’s disease, have already reported relatively promising results [ 83 ].…”

Section: Neuregulins Ggf2 and Future Therapeutic Perspectives For Pos...mentioning

confidence: 99%

Rats, Neuregulins and Radical Prostatectomy: A Conceptual Overview

Novacescu

Neşiu

Bardan

et al. 2023

JCM

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In the contemporary era of early detection, with mostly curative initial treatment for prostate cancer (PC), mortality rates have significantly diminished. In addition, mean age at initial PC diagnosis has decreased. Despite technical advancements, the probability of erectile function (EF) recovery post radical prostatectomy (RP) has not significantly changed throughout the last decade. Due to virtually unavoidable intraoperative cavernous nerve (CN) lesions and operations with younger patients, post-RP erectile dysfunction (ED) has now begun affecting these younger patients. To address this pervasive limitation, a plethora of CN lesion animal model investigations have analyzed the use of systemic/local treatments for EF recovery post-RP. Most promisingly, neuregulins (NRGs) have demonstrated neurotrophic effects in both neurodegenerative disease and peripheral nerve injury models. Recently, glial growth factor 2 (GGF2) has demonstrated far superior, dose-dependent, neuroprotective/restorative effects in the CN injury rat model, as compared to previous therapeutic counterparts. Although potentially impactful, these initial findings remain limited and under-investigated. In an effort to aid clinicians, our paper reviews post-RP ED pathogenesis and currently available therapeutic tools. To stimulate further experimentation, a standardized preparation protocol and in-depth analysis of applications for the CN injury rat model is provided. Lastly, we report on NRGs, such as GGF2, and their potentially revolutionary clinical applications, in hopes of identifying relevant future research directions.

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“…Neuregulins (NRGs) are a family of signalling proteins 5,6 , that are synthesised and secreted mainly in muscle 6 , but can also be produced in liver and adipose tissue [7][8][9] . There are 4 isoforms (NRG1 to NRG4) 10 .…”

Section: Introductionmentioning

confidence: 99%

“…There are 4 isoforms (NRG1 to NRG4) 10 . NRG1 plays an important role in the liver, heart, skeletal muscle and nervous system 5,6 . NRG4 is highly expressed in adipose tissue 7,9,11 .…”

Section: Introductionmentioning

confidence: 99%

High fat diet- induced obesity decreases ErbB receptors expression in liver and adipose tissue in C57BL/6 mice

Tapia,

Escobedo,

Campos

et al. 2024

Rev. chil. nutr.

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Neuregulins (NRGs) are a family of signaling proteins that bind to receptor tyrosine kinases of the ErbB family (ErbB2 to ErbB4), which can homo-or heterodimerize depending on their structural features and cell type. Many studies have proposed that decreased NRG levels are a common characteristic of obesity. In liver and adipose tissue, the increase in NRG expression has protective effects against obesity. However, it is still unknown whether ErbBs expression is altered in this pathology. We hypothesized that high fat diet-induced obesity downregulates ErbB receptors expression in obese mice compared to normal weight mice. Males C57BL/6 mice (n=6-7 for each group) were fed for 12 weeks and divided into: (i) control diet (CD; 10%-kcal fat, 20%-kcal protein, 70%-kcal carbohydrates), and (ii) high fat diet (HFD; 60%-kcal fat, 20%-kcal protein, 20%-kcal carbohydrates). General parameters and ErbBs expression (qPCR, immunohistochemistry and Western blot) were evaluated. We observed a significant increase in final body weight (47%), adipose tissue to body weight ratio (244%) and HOMA-IR (69%), among other parameters, in obese mice. In HFD group significantly decreased ErbB2 (48%) and ErbB3 (66%) mRNA levels in liver (no change in ErbB4), and ErbB2 (43%), ErbB3 (76%) and ErbB4 (35%) in adipose tissue, compared to CD. Furthermore, ErbB2 and ErbB3 protein levels decreased significantly in HFD group compared to the CD in liver. Therefore, our results suggest that HFD-induced obesity significantly decreases ErbBs expression in liver and adipose tissue in this murine model, that may be associated with alterations in the NRG pathway in obese mice.

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Neuregulins

Cited by 5 publications

References 34 publications

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Rats, Neuregulins and Radical Prostatectomy: A Conceptual Overview

High fat diet- induced obesity decreases ErbB receptors expression in liver and adipose tissue in C57BL/6 mice

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