Neuregulin Expression in PNS Neurons: Isoforms and Regulation by Target Interactions

Bermingham‐McDonogh, Olivia; Xu, Yi; Marchionni, Mark A.; Scherer, Steven S.

doi:10.1006/mcne.1997.0654

Cited by 64 publications

(58 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neuronal type III Nrg1 expression declines after axon transection, but is restored as axons reinnervate their targets and may therefore depend on target-derived growth factors (Bermingham-McDonogh et al, 1997). After axon destruction, type I Nrg1 expression in Schwann cells is transiently upregulated (Stassart et al, 2013).…”

Section: Nrg1 and Remyelination After Injurymentioning

confidence: 99%

Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair

Birchmeier

Bennett

2016

Current Topics in Developmental Biology

View full text Add to dashboard Cite

Myelin is essential for rapid and accurate conduction of electrical impulses by axons in the central and peripheral nervous system. Myelin is formed in the early postnatal period, and developmental myelination in the peripheral nervous system (PNS) depends on axonal signals provided by Nrg1/ErbB receptors. In addition, Nrg1 is required for effective nerve repair and remyelination in adulthood. We discuss here similarities and differences in Nrg1/ErbB functions in developmental myelination and remyelination after nerve injury.

show abstract

Section: Nrg1 and Remyelination After Injurymentioning

confidence: 99%

Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair

Birchmeier

Bennett

2016

Current Topics in Developmental Biology

View full text Add to dashboard Cite

show abstract

“…in those neurons that project into the periphery and are accompanied by Schwann cells (Bermingham-McDonogh et al, 1997;Ho et al, 1995;Meyer et al, 1997). Incidentally, this NRG1 isoform was first termed ''sensory and motor neuron derived factor'' or SMDF (Ho et al, 1995).…”

Section: Nrg1 Is a Growth Maturation And Motility Factor For Schwanmentioning

confidence: 99%

Neuregulin‐1, a key axonal signal that drives Schwann cell growth and differentiation

Birchmeier¹,

Nave

2008

Glia

215

167

View full text Add to dashboard Cite

Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed ''neuregulin'', promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by this factor is thus clearly astounding. V V C

show abstract

“…Guertin and coworkers examined the levels of erbB2 activation immediately following sciatic nerve transection and found that there is also an acute and transient increase in the levels of phosphorylated erbB2 and erbB3 in the first hour following injury, which decreases again by 3 h postinjury [80]. In chronically denervated sciatic nerves, expression levels of erbB receptors are much decreased [81].From 3 days postinjury a sustained increase in erbB2 and erbB3 expression is seen, and activation of these receptors is indicated by enhanced phosphorylation of erbB2; this is the time at which SCs undergo injury-induced proliferation [79].The expression of NRG1 type III by peripheral neurons initially decreases following nerve injury and then increases as axons begin to re-inner vate their targets [77,82]. Similar results were found in a facial nerve transection model where neuronal NRG1 type III levels were significantly downregulated and did not recover until 14 days postinjury [83].…”

mentioning

confidence: 99%

The Role of Neuregulin-1 In the Response To Nerve Injury

Fricker

Bennett

2011

Future Neurol.

View full text Add to dashboard Cite

Axons and Schwann cells exist in a highly interdependent relationship: damage to one cell type invariably leads to pathophysiological changes in the other. Greater understanding of communication between these cell types will not only give insight into peripheral nerve development, but also the reaction to and recovery from peripheral nerve injury. The type III isoform of neuregulin-1 (NRG1) has emerged as a key signaling factor that is expressed on axons and, through binding to erbB2/3 receptors on Schwann cells, regulates multiple phases of their development. In adulthood, NRG1 is dispensable for the maintenance of the myelin sheath; however, this factor is required for both axon regeneration and remyelination following nerve injury. The outcome of NRG1 signaling depends on interactions with other pathways within Schwann cells such as Notch, integrin and cAMP signaling. In certain circumstances, this signaling pathway may be maladaptive; for instance, direct binding of Mycobacterium leprae onto erbB2 receptors produces excessive activation and can actually promote demyelination. Attempts to modulate this pathway in order to promote nerve repair will therefore need to give consideration to the exact isoform used, as well as how it is processed and the context in which it is presented to the Schwann cell. Keywordsneuregulin-1; neuropathy; peripheral nerve injury; regeneration; remyelination; repair; Schwann cell Peripheral nerve injury causes significant morbidity and reduced quality of life as a consequence of weakness, sensory loss and neuropathic pain. In total, 6% of the elderly population suffer from peripheral neuropathy [1], which can be caused by metabolic diseases such as diabetes, inherited genetic disorders such as Charcot-Marie-Tooth disease, infectious and inflammatory disorders including Guillan-Barré syndrome and traumatic injury to the nerve (which alone effects up to 300,000 people in Europe per year [1,2]). In contrast to the CNS, peripheral nerves have a significant regenerative capacity [3]; however, in patients, regeneration and the clinical outcome are often poor. Axons regenerate at a rate of approximately 1 mm per day, depending on the site of the lesion. There may be a delay of months if not years before the target zone is re-innervated, and by this time, the target organ and supporting cells may have irreversibly changed, becoming much less receptive to reinnervation. The current approaches to peripheral nerve repair following nerve transection are either to surgically suture the nerve or to bridge the gap between the two cut ends. Financial & competing interests disclosureThe authors have no other rel evant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Europe PMC Funders Group NRGs & the PNSNRGs Neuregulins are a family of growth factors en...

show abstract

Neuregulin Expression in PNS Neurons: Isoforms and Regulation by Target Interactions

Cited by 64 publications

References 59 publications

Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair

Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair

Neuregulin‐1, a key axonal signal that drives Schwann cell growth and differentiation

The Role of Neuregulin-1 In the Response To Nerve Injury

Contact Info

Product

Resources

About