Neuregulin-3 in the Mouse Medial Prefrontal Cortex Regulates Impulsive Action

Loos, Maarten; Mueller, Thomas; Gouwenberg, Yvonne; Wijnands, Ruud; Loo, Rolinka J. van der; Birchmeier, Carmen; Smit, August B.; Spijker, Sabine

doi:10.1016/j.biopsych.2014.02.011

Cited by 55 publications

(78 citation statements)

References 60 publications

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“…In fact, data from introgression mouse strains (recombinant inbred lines, chromosome substitution strains (Gora-Maslak et al, 1991;Singer et al, 2004;Threadgill et al, 2011)) suggest that variation in different chromosomes indeed has a substantial impact on the phenotypic expression of a given variation. For instance, substitution of chromosomes of A/J mice into Bl6 mouse genomes produced anxiety effects that together add up to much more than the difference between the parental strains (Singer et al, 2004), and recombinant inbred lines showed more phenotypic variation in impulsivity then the parental strains (Loos et al, 2014b). Hence, epistasis appears to be a dominant factor at least in mouse behavior.…”

Section: Discussionmentioning

confidence: 99%

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences

et al. 2015

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“…A risk SNP that lies within a DNA ultra-conserved element strongly predicts elevated brain expression of NRG3 splice isoforms in SZ patients and normal controls (Kao et al, 2010). In mice, Nrg3 expression in the prefrontal cortex and knockout increased and decreased, respectively, impulsivity, a symptom of schizophrenia (Loos et al, 2014). …”

Section: Susceptibility Genes For Schizophrenia Bipolar Disorder Andmentioning

confidence: 99%

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

Mei

Nave

2014

Neuron

495

464

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Summary Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor tyrosine kinases. NRGs and their receptors ERBBs have been identified as susceptibility genes for diseases such as schizophrenia (SZ) and bipolar disorder. Recent studies have revealed complex Nrg/Erbb signaling networks that regulate the assembly of neural circuitry, myelination, neurotransmission and synaptic plasticity. Evidence indicates there is an optimal level of NRG/ERBB signaling in the brain and deviation from it impairs brain functions. NRGs/ERBBs and downstream signaling pathways may provide therapeutic targets for specific neuropsychiatric symptoms.

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“…AAV serotype 2 (AAV2) particles that contained the CMV minimal promoter and the coding gene sequence of Bcan or green fluorescent protein (AAV-GFP) were produced and purified using a two-plasmid crosspackaging system as described previously (Loos et al, 2014). For intracranial injections, mice were anesthetized with isoflurane, received 0.1 mg/kg Temgesic (RB Pharmaceuticals, UK) and were mounted in a stereotactic frame.…”

Section: Aav2 Vectors and Intracranial Micro-injectionmentioning

confidence: 99%

The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference

Lubbers

Matos

Horn

et al. 2015

Neuropsychopharmacol

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Cocaine-associated environmental cues sustain relapse vulnerability by reactivating long-lasting memories of cocaine reward. During periods of abstinence, responding to cocaine cues can time-dependently intensify a phenomenon referred to as 'incubation of cocaine craving'. Here, we investigated the role of the extracellular matrix protein brevican in recent (1 day after training) and remote (3 weeks after training) expression of cocaine conditioned place preference (CPP). Wild-type and Brevican heterozygous knock-out mice, which express brevican at~50% of wild-type levels, received three cocaine-context pairings using a relatively low dose of cocaine (5 mg/kg). In a drug-free CPP test, heterozygous mice showed enhanced preference for the cocaine-associated context at the remote time point compared with the recent time point. This progressive increase was not observed in wild-type mice and it did not generalize to contextualfear memory. Virally mediated overexpression of brevican levels in the hippocampus, but not medial prefrontal cortex, of heterozygous mice prevented the progressive increase in cocaine CPP, but only when overexpression was induced before conditioning. Postconditioning overexpression of brevican did not affect remote cocaine CPP, suggesting that brevican limited the increase in remote CPP by altering neuro-adaptive mechanisms during cocaine conditioning. We provide causal evidence that hippocampal brevican levels control time-dependent enhancement of cocaine CPP during abstinence, pointing to a novel substrate that regulates incubation of responding to cocaine-associated cues.

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Neuregulin-3 in the Mouse Medial Prefrontal Cortex Regulates Impulsive Action

Cited by 55 publications

References 60 publications

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference

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