Neuregulin-1 (Nrg1): An Emerging Regulator of Prolactin (PRL) Secretion

Zhao, Wenjin

doi:10.5772/54716

Cited by 4 publications

(5 citation statements)

References 47 publications

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“…Different from soluble NRG1, the membrane-tethered isoform contains a transmembrane (TM) domain and an intracellular domain (ICD). The ICD can be further characterized as ICD a, b, and c. The structure that bridges the extracellular and TM domains is called stem (S) and can be further divided into S1, S2 and S4 (Zhao, 2013a). Proteolysis of NRG1 precursor proteins is a highly regulated biological process, releasing soluble domains to form autocrine/paracrine loops.…”

Section: Structure Distribution and Biological Functions Of Neuregulinmentioning

confidence: 99%

“…Proteolysis of NRG1 precursor proteins is a highly regulated biological process, releasing soluble domains to form autocrine/paracrine loops. However, the recruitment of S3 containing stop codon terminates the extension of the extracellular domain into the cytoplasm, leading to the formation of non-membrane anchored NRG1 α/β (Zhao, 2013a; Figure 1).…”

Section: Structure Distribution and Biological Functions Of Neuregulinmentioning

confidence: 99%

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Neuregulins in Neurodegenerative Diseases

Lin

Zhao

2021

Front. Aging Neurosci.

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Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal loss and neurological dysfunctions in the nervous system, affecting both memory and motor functions. Neuregulins (NRGs) belong to the epidermal growth factor (EGF)-like family of extracellular ligands and they play an important role in the development, maintenance, and repair of both the central nervous system (CNS) and peripheral nervous system (PNS) through the ErbB signaling pathway. They also regulate multiple intercellular signal transduction and participate in a wide range of biological processes, such as differentiation, migration, and myelination. In this review article, we summarized research on the changes and roles of NRGs in neurodegenerative diseases, especially in AD. We elaborated on the structural features of each NRG subtype and roles of NRG/ErbB signaling networks in neurodegenerative diseases. We also discussed the therapeutic potential of NRGs in the symptom remission of neurodegenerative diseases, which may offer hope for advancing related treatment.

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Section: Structure Distribution and Biological Functions Of Neuregulinmentioning

confidence: 99%

Section: Structure Distribution and Biological Functions Of Neuregulinmentioning

confidence: 99%

Neuregulins in Neurodegenerative Diseases

Lin

Zhao

2021

Front. Aging Neurosci.

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“…Zhao [47] mentioned that this gene could influence the weaning weight as an emerging regulator of prolactin secretion.…”

Section: Discussionmentioning

confidence: 99%

Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle

Zepeda-Batista

Núñez-Domínguez

Ramírez‐Valverde

et al. 2021

Genes

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A genome-wide association study (GWAS) was performed to elucidate genetic architecture of growth traits in Braunvieh cattle. Methods: The study included 300 genotyped animals by the GeneSeek® Genomic Profiler Bovine LDv.4 panel; after quality control, 22,734 SNP and 276 animals were maintained in the analysis. The examined phenotypic data considered birth (BW), weaning (WW), and yearling weights. The association analysis was performed using the principal components method via the egscore function of the GenABEL version 1.8-0 package in the R environment. The marker rs133262280 located in BTA 22 was associated with BW, and two SNPs were associated with WW, rs43668789 (BTA 11) and rs136155567 (BTA 27). New QTL associated with these liveweight traits and four positional and functional candidate genes potentially involved in variations of the analyzed traits were identified. The most important genes in these genomic regions were MCM2 (minichromosome maintenance complex component 2), TPRA1 (transmembrane protein adipocyte associated 1), GALM (galactose mutarotase), and NRG1 (neuregulin 1), related to embryonic cleavage, bone and tissue growth, cell adhesion, and organic development. This study is the first to present a GWAS conducted in Braunvieh cattle in Mexico providing evidence for genetic architecture of assessed growth traits. Further specific analysis of found associated genes and regions will clarify its contribution to the genetic basis of growth-related traits.

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“…In cattle, NRG1 has been highly associated with organ development (Sweeney et al, 2001). Zhao (2013) mentioned that this gene could in uence the weaning weight as an emerging regulator of prolactin secretion.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Analysis for Liveweight Traits in Braunvieh Cattle

Zepeda-Batista

Núñez-Domínguez

Ramírez‐Valverde

et al. 2021

Preprint

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A genome-wide association study (GWAS) for liveweight traits of Braunvieh cattle was performed. The study included 300 genotyped animals by the GeneSeek® Genomic Profiler Bovine LDv.4 panel; after quality control, 22,734 SNP and 276 animals were maintained in the analysis. The examined phenotypic data considered birth, weaning, and yearling weights. The association analysis was performed using the principal components method via the egscore function of the GenABEL version 1.8-0 package in the R environment. The marker rs133262280 located in BTA 22 was associated with birth weight, and two SNPs were associated with weaning weight, rs43668789 (BTA 11) and rs136155567 (BTA 27). New QTL associated with these liveweight traits and four positional and functional candidate genes potentially involved in variations of the analyzed traits were identified. The most important genes in these genomic regions were MCM2 (minichromosome maintenance complex component 2), TPRA1 (transmembrane protein adipocyte associated 1), GALM (galactose mutarotase), and NRG1 (neuregulin 1), with relationships with embryonic cleavage, bone and tissue growth, cell adhesion, and organic development. This study is the first to present a GWAS conducted in Braunvieh cattle in Mexico and represents a basis for future research. Further analyses of found associated regions will clarify its contribution to the genetic basis of growth-related traits.

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Neuregulin-1 (Nrg1): An Emerging Regulator of Prolactin (PRL) Secretion

Cited by 4 publications

References 47 publications

Neuregulins in Neurodegenerative Diseases

Neuregulins in Neurodegenerative Diseases

Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle

Genome-Wide Association Analysis for Liveweight Traits in Braunvieh Cattle

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