Neuraxial drug delivery in pain management: An overview of past, present, and future

Yaksh, Tony L.; Santos, Gilson dos; Lemes, Júlia Borges Paes; Malange, Kauê Franco

doi:10.1016/j.bpa.2023.04.003

Cited by 2 publications

(1 citation statement)

References 181 publications

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“…Furthermore, the same receptors can produce neurotransmitters (thanks to a self-generation of electric potential) capable of altering the tissue they innervate [ 24 ]. In general, viscera-derived afferents cluster in the spinal dorsal root ganglia (DRG), but the molecular information released by visceral receptors can arrive in any medullary area and/or involve the sympathetic and parasympathetic systems [ 22 , 25 ]. Furthermore, in the neurophysiological reality of the living, the information coming from the visceral area is indistinguishable from the somatic one at the medullary level (due to the synaptic convergence of the viscera-soma), making it difficult to schematize a symptom that necessarily derives from the viscera or from the somatic structure [ 10 ].…”

Section: Reviewmentioning

confidence: 99%

Practice of Peritoneal Adhesions in Osteopathic Medicine: Part 2

Bordoni,

Girgenti,

Escher

2023

Cureus

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Peritoneal adhesions are an unwanted and frequent event following abdominal surgery, with a response rate that can reach 100%. The adhesions can be symptomatic, becoming a source of pain and discomfort for the patient, or asymptomatic, with possible chronic or acute visceral dysfunction. The article reviews what the diagnostic strategies are and discusses what could be the causes that lead to chronic pain in the presence of adhesions. The text reports the knowledge of the literature on the manual treatment of adhesions and illustrates possible symptoms that are not easily recognized by the clinician. To conclude, the article proposes osteopathic manual approaches derived from clinical experience and from what has been explained about the formation of peritoneal adhesions. Research must make further efforts to identify not only the causes triggering the formation of peritoneal neogenesis but also seek the most appropriate non-invasive treatments to help the patient.

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