Neurally mediated depressor hemodynamic response induced by intracoronary catheter balloon inflation in pigs

Cinca, Juan; Rodríguez‐Sinovas, Antonio; Anivarro, I; Moure, Cristina; Tresànchez, Màrius; Soler‐Soler, Jordi

doi:10.1016/s0008-6363(00)00010-9

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Sensory neurons are widely spread throughout the mammalian cardiovascular system and contain cardio-stimulatory neuropeptides. Among the neuropeptides, calcitonin gene-related peptide (CGRP), substance P and other neurokines play an intricate role in modulating cardiac function through local cardiac reflexes [94–96]. CGRP release is regulated by multiple factors such as brief ischemia, hyperthermia or autocoids [97–99].…”

Section: Circulating Mediators Of Ischemic Conditioningmentioning

confidence: 99%

Circulating mediators of remote ischemic preconditioning: search for the missing link between non-lethal ischemia and cardioprotection

et al. 2019

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Acute myocardial infarction (AMI) is one of the leading causes of mortality and morbidity worldwide. There has been an extensive search for cardioprotective therapies to reduce myocardial ischemia-reperfusion (I/R) injury. Remote ischemic preconditioning (RIPC) is a phenomenon that relies on the body's endogenous protective modalities against I/R injury. In RIPC, non-lethal brief I/R of one organ or tissue confers protection against subsequent lethal I/R injury in an organ remote to the briefly ischemic organ or tissue. Initially it was believed to be limited to direct myocardial protection, however it soon became apparent that RIPC applied to other organs such as kidney, liver, intestine, skeletal muscle can reduce myocardial infarct size. Intriguing discoveries have been made in extending the concept of RIPC to other organs than the heart. Over the years, the underlying mechanisms of RIPC have been widely sought and discussed. The involvement of blood-borne factors as mediators of RIPC has been suggested by a number of research groups. The main purpose of this review article is to summarize the possible circulating mediators of RIPC, and recent studies to establish the clinical efficacy of these mediators in cardioprotection from lethal I/R injury.

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Section: Circulating Mediators Of Ischemic Conditioningmentioning

confidence: 99%

Circulating mediators of remote ischemic preconditioning: search for the missing link between non-lethal ischemia and cardioprotection

et al. 2019

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“…Thus, in balloon-induced coronary occlusion, there is vagal predominance, which can represent a beneficial adaptive mechanism to increase coronary blood flow during myocardial ischemia. Conversely, when coronary perfusion is deficient, an increase in sympathetic activity occurs 27-29 . In the present study, an increase in the LF and HF components was observed, with no significant change in the LF/HF ratio, during stent implantation, as compared with the values of those variables before and after the procedure.…”

Section: Discussionmentioning

confidence: 99%

Spectral Analysis Related to Bare-Metal and Drug-Eluting Coronary Stent Implantation

Silva¹,

Silva²,

Greco³

et al. 2014

Arquivos Brasileiros De Cardiologia

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BackgroundThe autonomic nervous system plays a central role in cardiovascular regulation; sympathetic activation occurs during myocardial ischemia. ObjectiveTo assess the spectral analysis of heart rate variability during stent implantation, comparing the types of stent. MethodsThis study assessed 61 patients (mean age, 64.0 years; 35 men) with ischemic heart disease and indication for stenting. Stent implantation was performed under Holter monitoring to record the spectral analysis of heart rate variability (Fourier transform), measuring the low-frequency (LF) and high-frequency (HF) components, and the LF/HF ratio before and during the procedure. ResultsBare-metal stent was implanted in 34 patients, while the others received drug-eluting stents. The right coronary artery was approached in 21 patients, the left anterior descending, in 28, and the circumflex, in 9. As compared with the pre-stenting period, all patients showed an increase in LF and HF during stent implantation (658 versus 185 ms2, p = 0.00; 322 versus 121, p = 0.00, respectively), with no change in LF/HF. During stent implantation, LF was 864 ms2 in patients with bare-metal stents, and 398 ms2 in those with drug-eluting stents (p = 0.00). The spectral analysis of heart rate variability showed no association with diabetes mellitus, family history, clinical presentation, beta-blockers, age, and vessel or its segment. ConclusionsStent implantation resulted in concomitant sympathetic and vagal activations. Diabetes mellitus, use of beta-blockers, and the vessel approached showed no influence on the spectral analysis of heart rate variability. Sympathetic activation was lower during the implantation of drug-eluting stents.

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“…One can find more than 100 references involving the use of CLS in this species in the open literature. It is an anaesthetic that is specifically recommended for the different fields of cardiovascular research (Bardaji et al, 1990;Benharkate et al, 1993;Cinca et al, 1996Cinca et al, , 2000Seaberg et al, 2001) and when the baroreflex should be conserved or studied (Svendsen, 1998;Wiklund et al, 2002). CLS produces minimal cardiovascular and respiratory system depression (Flecknell, 1987).…”

Section: Pressor Effects Of Na and Anaesthesiamentioning

confidence: 99%

Swine models in the design of more effective medical countermeasures against organophosphorus poisoning

et al. 2007

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Neurally mediated depressor hemodynamic response induced by intracoronary catheter balloon inflation in pigs

Abstract: A depressor hemodynamic response subserved by pericoronary nerves worsens the LV dysfunction induced by brief coronary catheter balloon inflation in anesthetized pigs. Cholinergic fibers do not appear to play a major role.

Cited by 7 publications

References 27 publications

Circulating mediators of remote ischemic preconditioning: search for the missing link between non-lethal ischemia and cardioprotection

Circulating mediators of remote ischemic preconditioning: search for the missing link between non-lethal ischemia and cardioprotection

Spectral Analysis Related to Bare-Metal and Drug-Eluting Coronary Stent Implantation

Swine models in the design of more effective medical countermeasures against organophosphorus poisoning

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