Neural Tube Defects: Distribution and Associated Anomalies Diagnosed by Prenatal Ultrasonography in Iranian Fetuses

Moradi, Behnaz; Katouli, Fatemeh Shakki; Gity, Masoumeh; Kazemi, Mohamad Ali; Shakiba, Madjid; Masrour, Farzaneh Fattahi

doi:10.5812/jogcr.64382

Cited by 4 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anencephaly was the most common (50%) congenital malformations among central nervous system in the present study. It was comparable with the study of Sunethri et al 14 (50%), Moradi et al 15 (50%), Kulkarni et al 16 (45%) and Saiyad & Jadav 17 (41.38%). According to Parthasaraty A 18 incidence of anencephaly was observed 1 in 1000 births.…”

Section: Discussionsupporting

confidence: 91%

Pattern of malformations in central nervous system and its association with other congenital anomalies in perinates

2020

IJCAP

View full text Add to dashboard Cite

Introduction:The congenital malformations of the central nervous system is one of the leading causes of perinatal mortality in this region of the country. It may present as an isolated defect or may be associated with other organ system malformations. Aims and Objectives: Aim of the present study was to find out the pattern of congenital malformations in the central nervous system both in live and still born perinates. Our main objective was to ascertain its association with other organ systems most commonly involved. Materials and Methods: The prospective study was carried out on 76 perinates having congenital anomalies out of 15,970 births (15,614 live born and 356 stillborn) ranging from 28th weeks of gestation to 7 days after birth. Twenty, out of 76 were born with central nervous system malformations. Results and Observations:The congenital malformations of central nervous system were found to be 26.31%. Anencephaly was the most common malformation ( 50%) observed amongst the central nervous system in the study with a female preponderance 1.5:1, followed by spina bifida with meningomyelocele (35%), hydrocephalus (10%) and holoprosencephaly (5%). Anencephaly was associated with occipital meningoencephalocele in 10% cases. Conclusion: Anencephaly is the most common malformations in the study, followed by spina bifida and meningomyelocele. The other malformations found in the central nervous system are hydrocephalus, meningoencephalocele and holoprosencephaly. The incidence of congenital malformations in present study is comparatively lower than in other parts of India and abroad.

show abstract

Section: Discussionsupporting

confidence: 91%

Pattern of malformations in central nervous system and its association with other congenital anomalies in perinates

2020

IJCAP

View full text Add to dashboard Cite

show abstract

“…Population differences might begin to explain variability in previous estimates of non-isolated NTD prevalence. The proportion of NTDs described as having comorbid malformations in community- or hospital-based studies ranges from 9.1% to 66% 13–19 . Our previous pathological anatomy study showed that 75.8% of NTD cases had additional malformations, of which the majority were musculoskeletal or visceral defects 20 .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-isolated neural tube defects with comorbid malformations are responsive to population-level folic acid supplementation in Northern China

Che

Liu

Galea

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective: Comorbid congenital malformation of multiple organs may indicate shared genetic/teratogenic causality. Folic acid supplementation reduces population-level prevalance of isolated neural tube defects (NTDs), but whether complex cases involving independent malformtions are also repsonsive is unknown. We aimed to describe the epidemiology of NTDs with comorbid malformations in a Chinese population and assess the impact of folic acid supplementation. Study Design: Data from five counties in northern China were obtained between 2002 to 2021 through a population-based birth defects surveillance system. All live births, stillbirths, and terminations because of NTDs at any gestational age were recorded. NTDs were classified as spina bifida, anaecephaly or encephalocele. Isolated NTDs included spina bifida cases with presumed secondary malformations (hydrocephalus, hip dislocation, talipes). Non-isolated NTDs were those with independent concomittant malformations. Results: A total of 296,306 births and 2,031 cases of NTDs were recorded in 2002-2021. 4.8 % of NTDs (97/2031) had comorbid defects, which primarily affected the abdominal wall (25/97), musculoskeletal system (24/97), central nervous system (22/97), and face (15/97). The relative risk of cleft lip or/and palate, limb reduction defects, hip dislocation, gastroschisis, omphalocele, hydrocephalus and urogenital system defects was significantly greater in infants with NTDs than the general population. Population-level folic acid supplementation significantly reduced the prevalence of both isolated and non-isolated NTDs. Conclusion: Epidemiologically, non-isolated NTDs follow similar trends as isolated cases and are responsive to primary prevention by folic acid supplementation. Various clinically-important congenital malformations are over-represented in individuals with NTDs, suggesting common etiology.

show abstract

“…Population differences might begin to explain variability in previous estimates of non-isolated NTD prevalence. The proportion of NTDs described as having comorbid malformations in community- or hospital-based studies ranges from 9.1% to 66% [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Our previous pathological anatomy study showed that 75.8% of NTD cases had additional malformations, of which the majority were musculoskeletal or visceral defects [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Isolated Neural Tube Defects with Comorbid Malformations Are Responsive to Population-Level Folic Acid Supplementation in Northern China

Che

Liu

Galea

et al. 2022

Biology

View full text Add to dashboard Cite

Objective: Comorbid congenital malformation of multiple organs may indicate a shared genetic/teratogenic causality. Folic acid supplementation reduces the population-level prevalence of isolated neural tube defects (NTDs), but whether complex cases involving independent malformations are also responsive is unknown. We aimed to describe the epidemiology of NTDs with comorbid malformations in a Chinese population and assess the impact of folic acid supplementation. Study Design: Data from five counties in Northern China were obtained between 2002 and 2021 through a population-based birth defects surveillance system. All live births, stillbirths, and terminations because of NTDs at any gestational age were recorded. NTDs were classified as spina bifida, anencephaly, or encephalocele. Isolated NTDs included spina bifida cases with presumed secondary malformations (hydrocephalus, hip dislocation, talipes). Non-isolated NTDs were those with independent concomitant malformations. Results: A total of 296,306 births and 2031 cases of NTDs were recorded from 2002–2021. A total of 4.8% of NTDs (97/2031) had comorbid defects, which primarily affected the abdominal wall (25/97), musculoskeletal system (24/97), central nervous system (22/97), and face (15/97). The relative risk of cleft lip and/or palate, limb reduction defects, hip dislocation, gastroschisis, omphalocele, hydrocephalus, and urogenital system defects was significantly greater in infants with NTDs than in the general population. Population-level folic acid supplementation significantly reduced the prevalence of both isolated and non-isolated NTDs. Conclusion: Epidemiologically, non-isolated NTDs follow similar trends as isolated cases and are responsive to primary prevention by folic acid supplementation. Various clinically-important congenital malformations are over-represented in individuals with NTDs, suggesting a common etiology.

show abstract

Neural Tube Defects: Distribution and Associated Anomalies Diagnosed by Prenatal Ultrasonography in Iranian Fetuses

Cited by 4 publications

References 20 publications

Pattern of malformations in central nervous system and its association with other congenital anomalies in perinates

Pattern of malformations in central nervous system and its association with other congenital anomalies in perinates

Non-isolated neural tube defects with comorbid malformations are responsive to population-level folic acid supplementation in Northern China

Non-Isolated Neural Tube Defects with Comorbid Malformations Are Responsive to Population-Level Folic Acid Supplementation in Northern China

Contact Info

Product

Resources

About