Neural systems and the inhibitory modulation of agonistic behavior: A comparison of mammalian species

Albert, D.J.; Walsh, M.L.

doi:10.1016/0149-7634(84)90017-4

Cited by 115 publications

(40 citation statements)

References 201 publications

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“…Major projection targets of EW include the lateral septum and dorsal raphe, both of which are heavily involved in the regulation of social behaviors, including pair bonding in voles [Albert and Walsh, 1984;Bachtell, Weitemier, and Ryabinin, 2004;Bittencourt, Vaughan, Arias, Rissman, Vale, and Sawchenko, 1999;Czlonkowski, Kostowski, Markowska, Markiewicz, and Wisniewska, 1975;File and Deakin, 1980;. Blockade of vasopressin receptors in the lateral septum prevents partner preference formation in prairie voles [Liu, Curtis, and Wang, 2001].…”

Section: Discussionmentioning

confidence: 99%

Distribution of Corticotropin-Releasing Factor and Urocortin 1 in the Vole Brain

et al. 2006

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Brain receptor patterns for the corticotropin-releasing factor (CRF) receptors, CRF1 and CRF2, are dramatically different between monogamous and promiscuous vole species, and CRF physiologically regulates pair bonding behavior in the monogamous prairie vole. However, little is known whether species differences also exist in the neuroanatomical distribution of the endogenous ligands for the CRF1 and CRF2 receptors, such as CRF and urocortin-1 (Ucn1). We compared the expression of CRF and Ucn1 in four vole species, monogamous prairie and pine voles, and promiscuous meadow and montane voles, using in situ hybridization of CRF and Ucn1 mRNA. Our results reveal that CRF mRNA expression patterns in all four vole species appear highly conserved throughout the brain, including the olfactory bulb, nucleus accumbens, bed nucleus of the stria terminalis, medial preoptic area, central amygdala, hippocampus, posterior thalamus, and cerebellum. Similarly, Ucn1 mRNA primarily localized to the Edinger-Westphal nucleus in all four vole species. Immunocytochemistry in prairie and meadow voles confirmed localization of CRF and Ucn1 protein to these previously identified brain regions. These data demonstrate a striking dichotomy between the extraordinary species diversity of brain receptor patterns when compared to the highly conserved brain distributions of their respective ligands. Our findings generate novel hypotheses regarding the evolutionary mechanisms underlying the neural circuitry of species-typical social behaviors. KeywordsCorticotropin-releasing hormone; CRF1; CRF2; median raphe; nucleus accumbens; EdingerWestphal nucleus List of AbbreviationsCRF Corticotropin-releasing factor; Ucn1 Urocortin 1; OB olfactory bulb; NAcc nucleus accumbens; BnST bed nucleus of stria terminalis; MPOA medial preoptic area; PVN paraventricular nucleus of the hypothalamus; hippo hippocampus; CeA central nucleus of the amygdala; thal posterior thalamus; MR median raphe nucleus; CBg cerebellum granular layer; EW Edinger-Westphal nucleus

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Section: Discussionmentioning

confidence: 99%

Distribution of Corticotropin-Releasing Factor and Urocortin 1 in the Vole Brain

et al. 2006

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“…Offensive and defensive aggression appear to be controlled through separate neural sites in rodents [Albert and Walsh, 1984;Blanchard and Blanchard, 1988]. In hamsters, a number of areas have been implicated in the control of offensive aggression, primarily through lesions and electrical stimulation studies.…”

Section: Introductionmentioning

confidence: 99%

Neural Connections of the Anterior Hypothalamus and Agonistic Behavior in Golden Hamsters

2000

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In male golden hamsters, offensive aggression is regulated by an interaction between arginine-vasopressin and serotonin at the level of the anterior hypothalamus. The present studies were conducted to study a neural network underlying this interaction. The connections of the anterior hypothalamus were examined by retrograde and anterograde tracing in adult male hamsters. Several limbic areas were found to contain both types of tracing suggesting reciprocal connections with the anterior hypothalamus. Their functional significance relating to the consummation of aggression was tested by comparing neuronal activity (examined through quantification of c-Fos-immunolabeling) in two groups of animals. Experimental animals were sacrificed after attacking an intruder. Control animals were sacrificed after exposure to a woodblock carrying the odor of an intruder that elicited behaviors related to offensive aggression without its consummation. An increased density of Fos-immunoreactivity was found in experimental animals within the medial amygdaloid nucleus, ventrolateral hypothalamus, bed nucleus of the stria terminalis and dorsolateral part of the midbrain central gray. These data suggest that these areas are integrated in a neural network centered on the anterior hypothalamus and involved in the consummation of offensive aggression. Finally, c-Fos-immunoreactivity was combined with labeling of serotonin and vasopressin neurons to identify sub-populations particularly associated with offensive aggression. Vasopressin neurons in the nucleus circularis and medial division of the supraoptic nucleus showed increased neuronal activity in the fighters, supporting their role in the control of offensive aggression.

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“…Since the physiological systems that sustain aggression (Albert and Walsh, 1984;Umukoro et al, 2012) and stress (de Kloet, 2010) are highly preserved throughout evolution, several animal models have been proposed to study the development of human aggressive behavior using rodents. However, very few models have included non-lactating females, possibly because aggressive behavior in female rodents is considered in general rare unless the females are protecting their offspring (for review, see Umukoro et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Long-term programming of enhanced aggression by peripuberty stress in female rats

Cordero

Ansermet

Sandi

2013

Psychoneuroendocrinology

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Summary Human literature has linked adverse early life experiences with an increased risk to develop violent behaviors in both boys and girls. We have previously shown that male rats submitted to stress during the peripuberty period display as adults abnormal aggressive behavior against both male intruders and female partners. In the present study, we examined whether the same stress protocol would affect the development of aggressive behaviors in female rats. We evaluated the behavior of these peripuberty stressed female rats when confronted, at adulthood, with either female or male intruders, and during their cohabitation with male partners. Given that estrus cycle influences mood and aggressive behaviors, female aggressive behavior was assessed at different estrus cycle phases: estrus and diestrus, and during pregnancy and lactancy. Additionally, we evaluated postpartum plasma levels of vasopressin, oxytocin and corticosterone, hormones associated with aggression and the regulation of social behavior. Compared to control females, females submitted to stressful events during puberty exhibited higher and more sustained rates of aggression during adulthood independently on the estrus cycle or the sex of the intruder, and they had higher levels of plasma vasopressin. Significant correlations between plasma levels of vasopressin and corticosterone and aggressive behavior were also found. Strikingly, our results showed opposite intragroup correlations suggesting a different role of these hormones on aggression depending on life experiences. We provide here an animal model, devoid of cultural influences strongly supporting a role for biological factors in the development of aggressive behaviors following exposure to stressful events at puberty in females. #

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Neural systems and the inhibitory modulation of agonistic behavior: A comparison of mammalian species

Cited by 115 publications

References 201 publications

Distribution of Corticotropin-Releasing Factor and Urocortin 1 in the Vole Brain

Distribution of Corticotropin-Releasing Factor and Urocortin 1 in the Vole Brain

Neural Connections of the Anterior Hypothalamus and Agonistic Behavior in Golden Hamsters

Long-term programming of enhanced aggression by peripuberty stress in female rats

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