Neural substrates of suicide and suicidal behaviour: from a neuroimaging perspective

Balcıoğlu, Yasin Hasan; Köse, Samet

doi:10.1080/24750573.2017.1420378

Cited by 38 publications

(28 citation statements)

References 116 publications

(153 reference statements)

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“…Not surprisingly, alterations in both the dorsal and the ventral striatum have been associated with depression and suicidality (Quevedo et al ., 2016 ). In contrast to research suggesting that alterations in the ventral striatum are indicative of risk for developing depression (Luking et al ., 2016 ), some researchers have posited that alterations in the dorsal striatum are implicated in suicidality (Balcioglu and Kose, 2017 ); this is consistent with our findings that reduced GMV of the dorsal striatum predicts implicit SI above and beyond the effect of depressive symptoms. Given the complex role of the putamen and caudate in both reward processing and motor response generation, one possibility is that aberrations in the dorsal striatum increase suicide-related risk through altered reward processing and diminished hedonic capacity (i.e.…”

Section: Discussionsupporting

confidence: 92%

Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents

Cichocki

Gifuni

et al. 2018

Social Cognitive and Affective Neuroscience

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Suicidal ideation (SI), a potent risk factor for suicide attempts, increases in adolescence. While alterations in dopaminergic functioning have been implicated in suicidal acts—particularly in adults—we do not know whether morphological alterations in dopamine-rich regions of the brain, such as the striatum, are vulnerability factors for the emergence of SI in adolescents. At baseline, a community sample of 152 adolescents (89 female; mean age: 11.41 ± 1.01 years) completed a magnetic resonance imaging (MRI) scan that was used to estimate gray matter volumes (GMVs) of three striatal structures: caudate, nucleus accumbens and putamen. At a 24 month follow-up session, participants completed a self-report measure of SI frequency [Suicidal Ideation Questionnaire (SIQ)] and the death version of the Implicit Association Test (IAT). Robust linear regression models were conducted to predict SIQ and IAT scores from striatal GMV. Bilateral putamen and left caudate GMV significantly predicted IAT scores (all Ps < 0.03). No other associations were significant (all Ps > 0.05). Our finding of reduced dorsal striatal GMV predicting implicit SI may indicate that downstream dopaminergic dysfunction is implicated in the development of overt suicidal behaviors. Self-reported SI was not associated with striatal GMV, suggesting that biological correlates of suicide risk may correlate specifically with objective measurements of SI in adolescents.

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Section: Discussionsupporting

confidence: 92%

Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents

Cichocki

Gifuni

et al. 2018

Social Cognitive and Affective Neuroscience

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“…The lifetime probability of suicide attempts is 20-25% among people with major mood disorders 117 . Prior studies had identified structural brain alterations in individuals with MDD and a history of suicidal thoughts and behaviors, with most consistent evidence for structural deficits in the ventromedial and ventrolateral PFC, dorsomedial and dorsolateral PFC, ACC, insula and posterior structures including PCC, temporal regions, and the cerebellum (for recent reviews, see [118][119][120][121][122][123] ). Findings of structural alterations in subcortical regions, including the amygdala, hippocampus and striatal regions have been less-consistent across studies.…”

Section: Suicidal Thoughts and Behaviorsmentioning

confidence: 97%

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

et al. 2020

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A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of largescale data sharing for mental health research.

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“…1). In the last 10 years, a number of excellent reviews on aspects of this research have emerged [6][7][8][9][10]. Here we review research across structural, functional, and neurochemical neuroimaging modalities, providing a narrative review of 131 neuroimaging studies with a focus on the most researched brain circuitries and findings that converge across studies.…”

Section: Introductionmentioning

confidence: 99%

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

et al. 2019

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Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within this narrative review, we conducted a comprehensive review of neuroimaging studies of STBs published to date and summarize the progress achieved on elucidating neurobiological substrates of STBs, with a focus on converging findings across studies. We review neuroimaging evidence across differing mental disorders for structural, functional, and molecular alterations in association with STBs, which converges particularly in regions of brain systems that subserve emotion and impulse regulation including the ventral prefrontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in the connections between these brain areas. The reviewed literature suggests that impairments in medial and lateral VPFC regions and their connections may be important in the excessive negative and blunted positive internal states that can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors. A combination of VPFC and DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning. The dorsal anterior cingulate cortex and insula may play important roles in switching between these VPFC and DPFC systems, which may contribute to the transition from suicide thoughts to behaviors. Future neuroimaging research of larger sample sizes, including global efforts, longitudinal designs, and careful consideration of developmental stages, and sex and gender, will facilitate more effectively targeted preventions and interventions to reduce loss of life to suicide.

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Neural substrates of suicide and suicidal behaviour: from a neuroimaging perspective

Cited by 38 publications

References 116 publications

Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents

Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

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