Neural substrates in secondary somatosensory area for the perception of different tactile sensations

Lee, Stephanie D.; Jung, Yujin; Chung, Yong An; Lee, Wonhye

doi:10.1002/ima.22160

Cited by 7 publications

(12 citation statements)

References 39 publications

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“…Prior to the FUS procedures, functional MRI (fMRI) was performed (on a separate day) to map the individual-specific SI and SII areas in the left hemisphere that are functionally eloquent for four different non-painful sensory stimuli—(1) vibrotactile, (2) pressure, (3) warmth, and (4) coolness [27]. Anatomical MRI and computed tomography (CT) scans of the head were also acquired on the same day.…”

Section: Methodsmentioning

confidence: 99%

“…Then, blood oxygenation level dependent (BOLD)-fMRI was conducted for each subject to map the individual-specific SI and SII areas, functionally eloquent for four different tactile stimulations of the right hand—(1) vibrotactile, (2) pressure, (3) warmth, and (4) coolness. The detailed stimulation paradigm for the fMRI and the image processing schemes are reported elsewhere [27]. …”

Section: Methodsmentioning

confidence: 99%

“…Individual-specific coordinates of the SI and SII in the left hemisphere were identified based on our previous study on the same participants [27]. Within the SI, local maxima of the activations corresponding to different tactile stimuli were closely clustered and overlapped each other; therefore, a single sonication target was assigned representing the SI area.…”

Section: Methodsmentioning

confidence: 99%

“…Within the SI, local maxima of the activations corresponding to different tactile stimuli were closely clustered and overlapped each other; therefore, a single sonication target was assigned representing the SI area. On the other hand, the locations of activation in the SII associated with different tactile stimuli showed a degree of spatial distributions (having a radius of 5.3 ± 2.6 mm; as identified from the local maximum in the activation probability) while a degree of individual variability existed (i.e., ranged from 2.1 to 10.3 mm; a group-level spatial distribution of the SII sub-regions was described elsewhere [27]). Thus, the SII areas were divided into four different spatial locations to be targeted by FUS.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, we were motivated to deliver neurostimulatory FUS to the SII, and to examine the outcomes in terms of subjective sensations felt by the individuals. The existence of spatially-distinct sub-regions within the SII for processing different types of tactile sensations [23, 27] prompted us to further explore the possibility that FUS stimulation of sensation-specific SII areas (i.e., vibrotactile, pressure, warmth, and coolness) may also induce corresponding types of tactile sensations. The FUS was also administered to both SI and SII simultaneously, and its effects were assessed.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound

et al. 2016

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BackgroundTranscranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcranial magnetic stimulation or transcranial direct current stimulation. We examined the presence of tactile sensations elicited by FUS stimulation of two separate brain regions in humans—the primary (SI) and secondary (SII) somatosensory areas of the hand, as guided by individual-specific functional magnetic resonance imaging data.ResultsUnder image-guidance, acoustic stimulations were delivered to the SI and SII areas either separately or simultaneously. The SII areas were divided into sub-regions that are activated by four types of external tactile sensations to the palmar side of the right hand—vibrotactile, pressure, warmth, and coolness. Across the stimulation conditions (SI only, SII only, SI and SII simultaneously), participants reported various types of tactile sensations that arose from the hand contralateral to the stimulation, such as the palm/back of the hand or as single/neighboring fingers. The type of tactile sensations did not match the sensations that are associated with specific sub-regions in the SII. The neuro-stimulatory effects of FUS were transient and reversible, and the procedure did not cause any adverse changes or discomforts in the subject’s mental/physical status.ConclusionsThe use of multiple FUS transducers allowed for simultaneous stimulation of the SI/SII in the same hemisphere and elicited various tactile sensations in the absence of any external sensory stimuli. Stimulation of the SII area alone could also induce perception of tactile sensations. The ability to stimulate multiple brain areas in a spatially restricted fashion can be used to study causal relationships between regional brain activities and their cognitive/behavioral outcomes.Electronic supplementary materialThe online version of this article (doi:10.1186/s12868-016-0303-6) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound

et al. 2016

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Altered functional connectivity differs in stroke survivors with impaired touch sensation following left and right hemisphere lesions

Goodin

Lamp

Vidyasagar

et al. 2018

NeuroImage: Clinical

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One in two survivors experience impairment in touch sensation after stroke. The nature of this impairment is likely associated with changes associated with the functional somatosensory network of the brain; however few studies have examined this. In particular, the impact of lesioned hemisphere has not been investigated. We examined resting state functional connectivity in 28 stroke survivors, 14 with left hemisphere and 14 with right hemisphere lesion, and 14 healthy controls. Contra-lesional hands showed significantly decreased touch discrimination. Whole brain functional connectivity (FC) data was extracted from four seed regions, i.e. primary (S1) and secondary (S2) somatosensory cortices in both hemispheres. Whole brain FC maps and Laterality Indices (LI) were calculated for subgroups. Inter-hemispheric FC was greater in healthy controls compared to the combined stroke cohort from the left S1 seed and bilateral S2 seeds. The left lesion subgroup showed decreased FC, relative to controls, from left ipsi-lesional S1 to contra-lesional S1 and to distributed temporal, occipital and parietal regions. In comparison, the right lesion group showed decreased connectivity from contra-lesional left S1 and bilateral S2 to ipsi-lesional parietal operculum (S2), and to occipital and temporal regions. The right lesion group also showed increased intra-hemispheric FC from ipsi-lesional right S1 to inferior parietal regions compared to controls. In comparison to the left lesion group, those with right lesion showed greater intra-hemispheric connectivity from left S1 to left parietal and occipital regions and from right S1 to right angular and parietal regions. Laterality Indices were significantly greater for stroke subgroups relative to matched controls for contra-lesional S1 (left lesion group) and contra-lesional S2 (both groups). We provide evidence of altered functional connectivity within the somatosensory network, across both hemispheres, and to other networks in stroke survivors with impaired touch sensation. Hemisphere of lesion was associated with different patterns of altered functional connectivity within the somatosensory network and with related function was associated with different patterns of altered functional connectivity within the somatosensory network and with related functional networks.

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Somatosensory cortical representations of assimilation effect by vibrotactile stimulation

Kim,

Jung,

Kim

et al. 2023

Preprint

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This study investigated neural activity related to the assimilation effect in the perception of vibrotactile stimuli. The assimilation effect refers to a tactile perceptual bias in which the perception of the vibrotactile frequency on one finger is biased towards a distracting vibrotactile stimulus targeting other types of mechanoreceptors on the different finger. The assimilation effect occurs not only between fingers on the same hand (in-hand) but also between fingers on different hands (across-hand). These behavioral aspects of the assimilation effect lead to an assumption that neural processes related to the assimilation effect would involve the integration of different tactile information mediated by the somatosensory cortex. We addressed this hypothesis by investigating brain responses using functional magnetic resonance imaging (fMRI) to vibrotactile stimuli that induced assimilation effect under in-hand and across-hand conditions. We first observed that the vibrotactile stimuli presented in this study activated primary (S1) and secondary (S2) somatosensory cortices. Yet, neural responses in these regions did not show correlations with individual assimilation effects, indicating that neural processing of vibrotactile signals in S1 and S2 would not be directly linked to the assimilation effect. Instead, we found that connectivity between S1 and medial prefrontal cortex (mPFC) was correlated with individual in-hand assimilation effects and that connectivity between S2 and posterior parietal cortex (PPC) was correlated with individual across-hand assimilation effects. These results suggest that the assimilation effect may be related to tactile information integration via functional connections between the somatosensory cortex and higher-order brain regions.Significant StatementThis study found that the vibrotactile assimilation effect is influenced by the functional connections between the somatosensory cortex and higher-order brain regions, with distinct neural correlates observed between conditions of stimuli applied across fingers or across hands. Individual differences in the degree of the assimilation effect were related to connectivity between somatosensory regions and mPFC/IPL. These results suggest that integrating different types of tactile information received from different locations would engage cortical networking of the somatosensory cortex with frontal and parietal regions.

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Neural substrates in secondary somatosensory area for the perception of different tactile sensations

Cited by 7 publications

References 39 publications

Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound

Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound

Altered functional connectivity differs in stroke survivors with impaired touch sensation following left and right hemisphere lesions

Somatosensory cortical representations of assimilation effect by vibrotactile stimulation

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