Neural substrate for suppression of omnipause neurons at the onset of saccades

Shinoda, Yoshikazu; Sugiuchi, Yuriko; Takahashi, Mamoru; Izawa, Yoshiko

doi:10.1111/j.1749-6632.2011.06171.x

Cited by 22 publications

(16 citation statements)

References 39 publications

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“…In addition, twitch velocities were similar regardless of the presence or absence of coexisting saccades (Supplementary Fig. 2F), suggesting that the twitches were generated independently from the r5 burst neurons 14,15,19 .…”

Section: Resultsmentioning

confidence: 86%

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Development of oculomotor circuitry independent of hox3 genes

Grove

Baker

2014

Nat Commun

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Hox genes have been shown to be essential in vertebrate neural circuit formation and their depletion has resulted in homeotic transformations with neuron loss and miswiring. Here we quantifiy four eye movements in the zebrafish mutant valentino and hox3 knockdowns and find that contrary to the classical model, oculomotor circuits in hindbrain rhombomeres 5-6 develop and function independently from hox3 genes. All subgroups of oculomotor neurons are present as well as their input and output connections. Ectopic connections are also established, targeting two specific subsets of horizontal neurons and the resultant novel eye movements coexist with baseline behaviors. We conclude that the high expression of hox3 genes in rhombomeres 5-6 serves to prevent an aberrant neuronal identity and behaviors, but does not appear to be necessary for a comprehensive assembly of functional oculomotor circuits.

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Section: Resultsmentioning

confidence: 86%

“…The saccadic circuit architecture 14,15,19,22 is shown in Figure 3A and Supplementary Figure 2B. As in fast phase resetting behavior (Fig.…”

Section: Resultsmentioning

confidence: 99%

Development of oculomotor circuitry independent of hox3 genes

Grove

Baker

2014

Nat Commun

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“…The frontal eye fields (FEF) in the cortex have been particularly studied as regions for decision-making in eye movements (Pierrot-Deseilligny et al, 2003). Neurons in these regions project directly to brain stem structures containing ocular motor neurons so that they can directly influence the production of saccades (Segraves, 1992; Shinoda et al, 2011). Following target appearance, there is accumulation of movement-related activity in these regions toward a threshold, and once the threshold is reached a saccade is triggered (Hanes and Schall, 1996).…”

Section: Introductionmentioning

confidence: 99%

LATER models of neural decision behavior in choice tasks

Noorani

2014

Front. Integr. Neurosci.

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Reaction time has been increasingly used over the last few decades to provide information on neural decision processes: it is a direct reflection of decision time. Saccades provide an excellent paradigm for this because many of them can be made in a very short time and the underlying neural pathways are relatively well-known. LATER (linear approach to threshold with ergodic rate) is a model originally devised to explain reaction time distributions in simple decision tasks. Recently, however it is being extended to increasingly more advanced tasks, including those with decision errors and those requiring voluntary control such as the antisaccade task and those where sequential decisions are required. The strength of this modeling approach lies in its detailed, quantitative predictions of behavior, yet LATER models still retain their conceptual simplicity that made LATER initially successful in explaining reaction times in simple decision tasks.

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“…A prediction of this hypothesis is that bilateral cFN inactivation suppresses the electrical elicitation of ipsilateral saccades. Concerning the triggering per se, for both ipsilateral and contralateral saccades, it would be interesting to test whether the premotor burst neurons fire because the omnipause neurons (Iwamoto et al 2009) are inhibited by the electrophysiological recruitment of glycinergic fastigioreticular neurons (Bagnall et al 2009) and/or the recruitment of inhibitory burst neurons contralateral to the stimulated cFN (Shinoda et al 2011).…”

Section: Neural Processes Leading To the Elicitation Of Ipsilateral Smentioning

confidence: 99%

Cerebellar control of saccade dynamics: contribution of the fastigial oculomotor region

Quinet

Goffart

2015

Journal of Neurophysiology

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Quinet J, Goffart L. Cerebellar control of saccade dynamics: contribution of the fastigial oculomotor region. J Neurophysiol 113: 3323-3336, 2015. First published March 5, 2015 doi:10.1152/jn.01021.2014The fastigial oculomotor region is the output by which the medioposterior cerebellum influences the generation of saccades. Recent inactivation studies reported observations suggesting an involvement in their dynamics (velocity and duration). In this work, we tested this hypothesis in the head-restrained monkey with the electrical microstimulation technique. More specifically, we studied the influence of duration, frequency, and current on the saccades elicited by fastigial stimulation and starting from a central (straight ahead) position. The results show ipsilateral or contralateral saccades whose amplitude and dynamics depend on the stimulation parameters. The duration and amplitude of their horizontal component increase with the duration of stimulation up to a maximum amplitude. Varying the stimulation frequency mostly changes their latency and the peak velocity (for contralateral saccades). Current also influences the metrics and dynamics of saccades: the horizontal amplitude and peak velocity increase with the intensity, whereas the latency decreases. The changes in peak velocity and in latency observed in contralateral saccades are not correlated. Finally, we discovered that contralateral saccades can be evoked at sites eliciting ipsilateral saccades when the stimulation frequency is reduced. However, their onset is timed not with the onset but with the offset of stimulation. These results corroborate the hypothesis that the fastigial projections toward the pontomedullary reticular formation (PMRF) participate in steering the saccade, whereas the fastigiocollicular projections contribute to the bilateral control of visual fixation. We propose that the cerebellar influence on saccade generation involves recruiting neurons and controlling the size of the active population in the PMRF.

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Neural substrate for suppression of omnipause neurons at the onset of saccades

Cited by 22 publications

References 39 publications

Development of oculomotor circuitry independent of hox3 genes

Development of oculomotor circuitry independent of hox3 genes

LATER models of neural decision behavior in choice tasks

Cerebellar control of saccade dynamics: contribution of the fastigial oculomotor region

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