Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering

Cheng, Tzu Yun; Chen, Ming Hong; Chang, Wen-Han; Huang, Meng; Wang, Tzu‐Wei

doi:10.1016/j.biomaterials.2012.11.043

Cited by 344 publications

(233 citation statements)

References 35 publications

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“…58 Thus, perhaps unsurprisingly, when the RADA16-1 nanofibers were decorated with the laminin-derived sequence Ile-Lys-Val-Ala-Val (IKVAV), 59 the hydrogel not only improved tissue regeneration but also supported the proliferation of NSCs in a rat brain surgery model up to 6 weeks posttransplantation. 60 Very importantly, this IKVAV-decorated RADA16-1 hydrogel was indeed able to reduce glial scar formation. The key indicator of the efficaciousness of the peptide hydrogel, however, is the ability of the hydrogel to promote resection of a transected rat spinal cord with a gap of .4 mm.…”

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confidence: 89%

Harnessing supramolecular peptide nanotechnology in biomedical applications

Chan

Lee

Zhuo

et al. 2017

IJN

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The harnessing of peptides in biomedical applications is a recent hot topic. This arises mainly from the general biocompatibility of peptides, as well as from the ease of tunability of peptide structure to engineer desired properties. The ease of progression from laboratory testing to clinical trials is evident from the plethora of examples available. In this review, we compare and contrast how three distinct self-assembled peptide nanostructures possess different functions. We have 1) nanofibrils in biomaterials that can interact with cells, 2) nanoparticles that can traverse the bloodstream to deliver its payload and also be bioimaged, and 3) nanotubes that can serve as cross-membrane conduits and as a template for nanowire formation. Through this review, we aim to illustrate how various peptides, in their various self-assembled nanostructures, possess great promise in a wide range of biomedical applications and what more can be expected.

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confidence: 89%

Harnessing supramolecular peptide nanotechnology in biomedical applications

Chan

Lee

Zhuo

et al. 2017

IJN

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“…Laminin-derived IKVAV motif was linked to self-assembling peptide RADA (16) to form a functional 3D peptide-based scaffold for NSC encapsulation. Beside differentiation of NSCs into neural cell in in vitro conditions, injection of this hydrogel into damaged brain tissue to fi ll the cavity and form a bridge for the gap eventually led to improvement in brain tissue regeneration (Cheng et al 2013 ).…”

Section: Mechanical and Physical Cuesmentioning

confidence: 99%

Bioactive Nanomaterials for Neural Engineering

et al. 2016

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“…78,79 Furthermore, the scaffolds composed of peptides can encapsulate stem cells and induce their differentiation into normal cells through bioactive peptides at a high density on the scaffold surface. 76,78,80 In a previous study, to improve cartilage regeneration, the hydrogels formed by the peptide KLD12 (KLDLKLD-LKLDL) were cocultured with primary bovine chondrocytes, and the results showed that peptide hydrogel retained the chondrocyte phenotype to produce a cartilage-like extracellular matrix and type II collagen. 35 After 4 weeks of culturing, the material stiffness of the extracellular matrix increased, and therefore, it was suggested that the KLD12 self-assembling peptide scaffold was promising for cartilage tissue repair.…”

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confidence: 99%