Neural stem cell therapy for cancer

Bagó, Juli R.; Sheets, Kevin; Hingtgen, Shawn

doi:10.1016/j.ymeth.2015.08.013

Cited by 58 publications

(48 citation statements)

References 104 publications

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“…A number of different cell-based vectors have previously been developed for the targeted delivery of anti-cancer therapeutics to primary and metastatic lesions [25][26][27][28][29][30][31] . While some cell types have shown promise due to their innate homing capabilities (i.e.…”

Section: Discussionmentioning

confidence: 99%

Visualizing tumour self-homing with magnetic particle imaging

Parkins¹,

Melo

Ronald

et al. 2020

Preprint

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Due to their innate tumour homing capabilities, in recent years, CTCs have been engineered to express therapeutic genes for targeted treatment of primary and metastatic lesions. Additionally, previous studies have incorporated optical or PET imaging reporter genes to enable noninvasive monitoring of therapeutic CTCs in preclinical tumour models. Here, we demonstrate for the first time, the ability of magnetic particle imaging (MPI) to sensitively detect systemically administered iron-labeled CTCs and to visualize tumour self-homing in a murine model of human breast cancer.

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Section: Discussionmentioning

confidence: 99%

Visualizing tumour self-homing with magnetic particle imaging

Parkins¹,

Melo

Ronald

et al. 2020

Preprint

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“…NSCs are typified by expression of nestin, Sox2, and other classic markers, together with expansion in culture media rich in epidermal and fibroblast growth factors [ 6 ]. NSCs can self-renew and differentiate into astrocytes, neurons, or oligodendrocytes, and have been widely employed to treat brain, breast [ 7 ], prostate [ 8 ], and lung [ 9 ] tumors.…”

Section: Stem Cell Definitions and Sourcesmentioning

confidence: 99%

“…Possible stem cell migration mechanisms have been extensively studied. NSC migration to tumor foci is triggered by hypoxia, which activates expression of chemoattractants [ 6 ]. Directional HSC migration depends on the interaction between chemokine, CXCL12, and its receptor, CXCR4 [ 17 ].…”

Section: Stem Cell Propertiesmentioning

confidence: 99%

Stem cells in cancer therapy: opportunities and challenges

et al. 2017

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Metastatic cancer cells generally cannot be eradicated using traditional surgical or chemoradiotherapeutic strategies, and disease recurrence is extremely common following treatment. On the other hand, therapies employing stem cells are showing increasing promise in the treatment of cancer. Stem cells can function as novel delivery platforms by homing to and targeting both primary and metastatic tumor foci. Stem cells engineered to stably express various cytotoxic agents decrease tumor volumes and extend survival in preclinical animal models. They have also been employed as virus and nanoparticle carriers to enhance primary therapeutic efficacies and relieve treatment side effects. Additionally, stem cells can be applied in regenerative medicine, immunotherapy, cancer stem cell-targeted therapy, and anticancer drug screening applications. However, while using stem cells to treat human cancers appears technically feasible, challenges such as treatment durability and tumorigenesis necessitate further study to improve therapeutic performance and applicability. This review focuses on recent progress toward stem cell-based cancer treatments, and summarizes treatment advantages, opportunities, and shortcomings, potentially helping to refine future trials and facilitate the translation from experimental to clinical studies.

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“…NSCs can be isolated, genetically engineered and differentiated in vitro and reinstated into the central nervous system (CNS). NSCs have potential for use in cell replacement therapies in various neurologic disorders as has been shown in several academic reports (55,56). NSCs can be defined as cells that self-renew constantly and have the potential to form intermediate and mature cells of neuronal and glial lineages (57).…”

Section: A Promising Novel Therapy For Cancer -Neural Stem Cell Therapymentioning

confidence: 99%

Current treatments for advanced melanoma and introduction of a promising novel gene therapy for melanoma (Review)

et al. 2016

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Metastatic melanoma is a fatal form of skin cancer that has a tendency to proliferate more rapidly than any other solid tumor. Since 2010, treatment options for metastatic melanoma have been developed including chemotherapies, checkpoint inhibition immunotherapies, e.g., anti‑cytotoxic T‑lymphocyte antigen‑4 (CTLA‑4) and anti‑programmed death‑1 (PD‑1), and molecular-targeted therapies, e.g., BRAF and MEK inhibitors. These treatments have shown not only high response rates yet also side‑effects and limitations. Notwithstanding its limitations, stem cell therapy has emerged as a new auspicious therapy for various tumor types. Since stem cells possess the ability to serve as a novel vehicle for delivering therapeutic or suicide genes to primary or metastatic cancer sites, these cells can function as part of gene‑directed enzyme prodrug therapy (GDEPT). This review focuses on introducing engineered neural stem cells (NSCs), which have tumor‑tropic behavior that allows NSCs to selectively approach primary and invasive tumor foci, as a potential gene therapy for melanoma. Therapy using engineered NSCs with cytotoxic agents resulted in markedly reduced tumor volumes and significantly prolonged survival rates in preclinical models of various tumor types. This review elucidates current treatment options for metastatic melanoma and introduces a promising NSC therapy.

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Neural stem cell therapy for cancer

Cited by 58 publications

References 104 publications

Visualizing tumour self-homing with magnetic particle imaging

Visualizing tumour self-homing with magnetic particle imaging

Stem cells in cancer therapy: opportunities and challenges

Current treatments for advanced melanoma and introduction of a promising novel gene therapy for melanoma (Review)

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