Neural state and trait bases of mood-incongruent memory formation and retrieval in first-episode major depression

Wingen, Guido van; Eijndhoven, Philip van; Cremers, Henk R.; Tendolkar, Indira; Verkes, Robbert J.; Buitelaar, Jan K.; Fernández, Guillén

doi:10.1016/j.jpsychires.2009.11.009

Cited by 56 publications

(37 citation statements)

References 53 publications

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“…Thus, patients with MDD have consistently demonstrated worse performance than healthy controls in verbal memory (Kaymak et al, 2010;MacQueen et al, 2003;Vythilingam et al, 2004;Sheline et al, 1999), recollection memory (Kaymak et al, 2010;MacQueen et al, 2003;Sheline et al, 1999), and in tests of visual memory (Kaymak et al, 2010;Reischies and Neu, 2000;Grant et al, 2001;Neu et al, 2005;van Wingen et al, 2010). Similar deficits have been reported in patients with late-onset depression in some (Hickie et al, 2005), but not all (Ballmaier et al, 2008;Greenberg et al, 2008), studies.…”

Section: Introductionsupporting

confidence: 53%

Dentate gyrus volume and memory performance in major depressive disorder

Travis

Coupland

Silversone

et al. 2015

Journal of Affective Disorders

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Section: Introductionsupporting

confidence: 53%

Dentate gyrus volume and memory performance in major depressive disorder

Travis

Coupland

Silversone

et al. 2015

Journal of Affective Disorders

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“…Contrary to our expectation, no differences were observed in the PFC or ACC during emotional encoding or recognition, indicating that activation of these regions during this task may be less related to clinical course. Because the lateral PFC has been found to be hyperactivated during retrieval of mood-incongruent stimuli in symptomatic phases of MDD and after recovery (Van Wingen et al, 2010), our results suggest a trait-related rather than a coursepredictive role of this region in memory processing. Activation of the medial PFC and posterior cingulate cortex during encoding of negative pictures has been associated with worsening of symptoms over an 18-month period (Foland-Ross et al, 2014).…”

Section: Discussionmentioning

confidence: 64%

Brain Activation During Emotional Memory Processing Associated with Subsequent Course of Depression

Opmeer

Veltman

et al. 2015

Neuropsychopharmacol

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Major depressive disorder (MDD) is characterized by a heterogeneous course and identifying patients at risk for an unfavorable course is difficult. Neuroimaging studies may identify brain predictors of clinical course and may help to further unravel the neurobiological processes underlying an unfavorable course. We investigated whether brain activation during an emotional memory paradigm is associated with depressive course. To this end, we followed 74 MDD patients and 45 healthy controls (HCs) for 2 years. At baseline, participants performed an emotional word-encoding and -recognition task during functional magnetic resonance imaging. Activation patterns were compared between patients with fast remission (n = 22), remission with recurrence (n = 23), non-remission (n = 29), and HCs. Additionally, linear relations of brain activation and time to remission during the follow-up period were investigated across patients. We observed that during encoding of negative words, non-remitters showed higher activation of the left insula than HCs. Groups also differed in activation of the right hippocampus and left amygdala during negative encoding, with a trend for higher activation in non-remitters compared with HCs. Furthermore, hippocampal activation during negative word encoding was significantly and positively correlated with time to remission, irrespective of illness severity. Our findings suggest that higher activation in the left insula could serve as a neural marker of a naturalistic non-remitting course, whereas higher hippocampal activation is associated with delayed remission. Longitudinal analyses should clarify whether abnormal activation progresses further as a function of time with depression or may serve as load-independent markers of MDD course.

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“…One study has suggested that the role of the fusiform gyrus and prefrontal cortex in memory processing may contribute to cognitive vulnerability to depression. 36 Right fusiform activation in response to happy faces is reduced in patients with MDD compared with healthy controls, 37 and modulation of activity in this face-processing sensory area has been suggested to contribute to changes in the attentional salience of such emotional stimu li. 38 Our finding of disrupted white matter integrity under this gyrus provides structural evidence of impairment in the neural circuit responsible for face recognition in patients with MDD from a brain connectivity point of view.…”

Section: Discussionmentioning

confidence: 99%