Neural responses to morphological, syntactic, and semantic properties of single words: An fMRI study☆

Davis, Matthew H.; Meunier, Fanny; Marslen–Wilson, William D.

doi:10.1016/s0093-934x(03)00471-1

Cited by 116 publications

(92 citation statements)

References 67 publications

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“…Alternatively, SMG could support semantic feature integration regardless of feature type (Snyder et al, 1995;Corina et al, 1999). Unlike in earlier studies (Davis et al, 2004;Hauk et al, 2008c;Hoenig et al, 2008), we did not observe a modulation of brain activity by visual and action-related features in sensory and motor cortex. This is because of the fact that the stimulus material was optimized for investigating acoustic conceptual features as the main purpose of this study.…”

Section: Discussioncontrasting

confidence: 95%

The Sound of Concepts: Four Markers for a Link between Auditory and Conceptual Brain Systems

Kiefer¹,

Sim²,

Herrnberger³

et al. 2008

J. Neurosci.

270

233

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Traditionally, concepts are conceived as abstract mental entities distinct from perceptual or motor brain systems. However, recent results let assume modality-specific representations of concepts. The ultimate test for grounding concepts in perception requires the fulfillment of the following four markers: conceptual processing during (1) an implicit task should activate (2) a perceptual region (3) rapidly and (4) selectively. Here, we show using functional magnetic resonance imaging and recordings of event-related potentials, that acoustic conceptual features recruit auditory brain areas even when implicitly presented through visual words. Fulfilling the four markers, the findings of our study unequivocally link the auditory and conceptual brain systems: recognition of words denoting objects, for which acoustic features are highly relevant (e.g.,"telephone"), ignited cell assemblies in posterior superior and middle temporal gyri (pSTG/ MTG) within 150 ms that were also activated by sound perception. Importantly, activity within a cluster of pSTG/MTG increased selectively as a function of acoustic, but not of visual and action-related feature relevance. The implicitness of the conceptual task, the selective modulation of left pSTG/MTG activity by acoustic feature relevance, the early onset of this activity at 150 ms and its anatomical overlap with perceptual sound processing are four markers for a modality-specific representation of auditory conceptual features in left pSTG/ MTG. Our results therefore provide the first direct evidence for a link between perceptual and conceptual acoustic processing. They demonstrate that access to concepts involves a partial reinstatement of brain activity during the perception of objects.

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Section: Discussioncontrasting

confidence: 95%

The Sound of Concepts: Four Markers for a Link between Auditory and Conceptual Brain Systems

Kiefer¹,

Sim²,

Herrnberger³

et al. 2008

J. Neurosci.

270

233

View full text Add to dashboard Cite

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“…These activation patterns are consistent with a number of previous investigations in healthy young subjects comparing words to nonwords or to nonverbal stimuli (e.g., tones or letter strings) [Davis et al, 2004;Fiebach et al, 2002;Price et al, 2003]. Moreover, these areas are also activated during judgment tasks that specifically target semantic processing for verbal or nonverbal stimuli [Binder et al, 1997;Demonet et al, 1994;Pugh et al, 1996;Simos et al, 2002].…”

Section: Cortical Activation For Lexicosemantic Representations In Adsupporting

confidence: 90%

“…Then, small volume correction (SVC) was applied (using P 0.05, corrected) on published coordinates for a priori brain regions considered to be involved in either phonological or lexicosemantic processing. For lexicosemantic knowledge, a 10-mm radius spherical volume was used centered on [(255, 14, 221); Majerus et al, 2002] for the anterior superior temporal sulcus, [(254, 248, 26), Davis, 2004] for the posterior middle temporal gyrus, [(261, 222, 217), Majerus et al, 2002] for the inferior temporal gyrus, [(247, 283, 25), Binder et al, 2005] for the inferior parietal lobule (angular gyrus), and [(245, 35, 24), Binder et al, 1996] for the inferior frontal gyrus [Binder, 2000;Binder et al, 1996Binder et al, , 1999Binder et al, , 2005Demonet et al, 1992Demonet et al, , 1994Howard et al, 1992;Majerus et al, 2002;Perani et al, 1996;Petersen et al, 1988;Price et al, 1996;Scott et al, 2000]. Similarly, a priori regions of interest for phonological levels of representation were based on previous studies of sublexical phonological processing of speech: SVC was centered on [(260, 24, 210) and (66, 212, 0), Scott et al, 2000] for the bilateral superior temporal sulci and [(253, 243, 6) and (56 230 4), Binder et al, 2000] for the bilateral posterior superior temporal gyri [Binder, 2000;Binder and Price, 2001;Binder et al, 2000;Burton et al, 2000Burton et al, , 2005Demonet et al, 1992Demonet et al, , 1994Hickok and Poeppel, 2000;Jacquemot et al, 2003;<...>…”

Section: Discussionmentioning

confidence: 99%

Neural substrates of phonological and lexicosemantic representations in Alzheimer's disease

Peters

Majerus

Collette

et al. 2007

Human Brain Mapping

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Abstract:The language profile of patients suffering from Alzheimer's disease (AD) is characterized not only by lexicosemantic impairments but also by phonological deficits, as shown by an increasing number of neuropsychological studies. This study explored the functional neural correlates underlying phonological and lexicosemantic processing in AD. Using H 215 O PET functional brain imaging, a group of mild to moderate AD patients and a group of age-matched controls were asked to repeat four types of verbal stimuli: words, wordlike nonwords (WL1), non-wordlike nonwords (WL2) and simple vowels. The comparison between the different conditions allowed us to determine brain activation preferentially associated with lexicosemantic or phonological levels of language representations. When repeating words, AD patients showed decreased activity in the left temporo-parietal and inferior frontal regions relative to controls, consistent with distorted lexicosemantic representations. Brain activity was abnormally increased in the right superior temporal area during word repetition, a region more commonly associated with perceptual-phonological processing. During repetition of WL1 and WL2 nonwords, AD patients showed decreased activity in the middle part of the superior temporal gyrus, presumably associated with sublexical phonological information; at the same time, AD patients showed larger activation than controls in the inferior temporal gyrus, typically associated with lexicosemantic levels of representation. Overall, the results suggest that AD patients use altered pathways to process phonological and lexicosemantic information, possibly related to a progressive loss of specialization of phonological and lexicosemantic neural networks. Hum Brain Mapp 30: [185][186][187][188][189][190][191][192][193][194][195][196][197][198][199] 2009. V V C 2007 Wiley-Liss, Inc.

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“…In contrast with these neuroimaging and neuropsychological results, Davis, Meunier, and Marslen-Wilson (2004) found no effects of morphological structure in an event-related f MRI study. The participants in their study were asked to perform a semantic task, to judge whether or not each item in a trial was a synonym of the preceding item.…”

contrasting

confidence: 91%

Dual-route processing of complex words: New fMRI evidence from derivational suffixation

Vannest

Polk

Lewis

2005

Cognitive, Affective, & Behavioral Neuroscience

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Many behavioral models of the comprehension of suffixed words assume a dual-route mechanism in which these words are accessed sometimes from the mental lexicon as whole units and sometimes in terms of their component morphemes (such as happiϩness). In related neuropsychological work, Ullman et al. (1997) proposed a dual-route model for past tense processing, in which the lexicon (used for access to irregularly inflected forms) corresponds to declarative memory and a medial temporal/ parietal circuit, and the rule system (used for computation of regularly inflected forms) corresponds to procedural memory and a frontal (including Broca's area)/basal ganglia circuit. We used functional MRI and a memory encoding task to test this model for derivationally suffixed words, comparing those words that show evidence of decompositional processing in behavioral studies (-ness, -less, and -able words) with derived words that do not show decomposition effects (-ity and -ation words). By examining Broca's area and the basal ganglia as regions of interest, we found that "decomposable" derived and inflected words showed increases in activity relative to nondecomposable suffixed words. Results support a dual-route model of lexical access of complex words that is consistent with the Ullman et al. proposal.

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Neural responses to morphological, syntactic, and semantic properties of single words: An fMRI study☆

Cited by 116 publications

References 67 publications

The Sound of Concepts: Four Markers for a Link between Auditory and Conceptual Brain Systems

The Sound of Concepts: Four Markers for a Link between Auditory and Conceptual Brain Systems

Neural substrates of phonological and lexicosemantic representations in Alzheimer's disease

Dual-route processing of complex words: New fMRI evidence from derivational suffixation

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