Neural representation and generation for RNA secondary structures
Zichao Yan,
William L. Hamilton,
Mathieu Blanchette
Abstract:Our work is concerned with the generation and targeted design of RNA, a type of genetic macromolecule that can adopt complex structures which influence their cellular activities and functions. The design of large scale and complex biological structures spurs dedicated graph-based deep generative modeling techniques, which represents a key but underappreciated aspect of computational drug discovery. In this work, we investigate the principles behind representing and generating different RNA structural modalitie… Show more
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