Neural regulations of the tumor microenvironment

Restaino, Anthony; Vermeer, Paola D.

doi:10.1096/fba.2021-00066

Cited by 15 publications

(11 citation statements)

References 113 publications

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“…Neurogenesis, similar to angiogenesis, is also an important modulator of cancer cells progression [ 87 ]. Literature data demonstrate the presence of nerves in the tumor microenvironment and their promotion of tumorigenesis and disease progression [ 88 ]. GO molecular function analysis revealed that among the discovered DEGs were those involved in kinase activity and protein binding.…”

Section: Discussionmentioning

confidence: 99%

Expression Profile and Diagnostic Significance of MicroRNAs in Papillary Thyroid Cancer

Rogucki

Sidorkiewicz

Niemira

et al. 2022

Cancers

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The incidence of papillary thyroid cancer (PTC) has increased in recent years. To improve the diagnostic management of PTC, we propose the use of microRNAs (miRNAs) as a biomarker. Our aim in this study was to evaluate the miRNA expression pattern in PTC using NanoString technology. We identified ten miRNAs deregulated in PTC compared with reference tissue: miR-146b-5p, miR-221-3p, miR-221-5p, miR-34-5p, miR-551b-3p, miR-152-3p, miR-15a-5p, miR-31-5p, and miR-7-5p (FDR < 0.05; |fold change (FC)| ≥ 1.5). The gene ontology (GO) analysis of differentially expressed miRNA (DEM) target genes identified the predominant involvement of epidermal growth factor receptor (EGFR), tyrosine kinase inhibitor resistance, and pathways in cancer in PTC. The highest area under the receiver operating characteristic (ROC) curve (AUC) for DEMs was found for miR-146-5p (AUC = 0.770) expression, indicating possible clinical applicability in PTC diagnosis. The combination of four miRNAs (miR-152-3p, miR-221-3p, miR-551b-3p, and miR-7-5p) showed an AUC of 0.841. Validation by real-time quantitative polymerase chain reactions (qRT-PCRs) confirmed our findings. The introduction of an miRNA diagnostic panel based on the results of our study may help to improve therapeutic decision making for questionable cases. The use of miRNAs as biomarkers of PTC may become an aspect of personalized medicine.

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Section: Discussionmentioning

confidence: 99%

Expression Profile and Diagnostic Significance of MicroRNAs in Papillary Thyroid Cancer

Rogucki

Sidorkiewicz

Niemira

et al. 2022

Cancers

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“…Interactions with the peripheral nervous system have been described in many tumors, including pancreatic, colorectal, and head and neck cancers, wherein sympathetic, parasympathetic, or sensory innervation influences tumor proliferation and invasiveness. 80 The unique characteristics of both glioma cells and the native cells of the CNS facilitate even more complex means of interaction ( Figure 2 ). Accumulating evidence suggests that bidirectional communication between the native nervous system cells and glioma cells can alter tumor growth kinetics and behavior.…”

Section: Nervous System Componentmentioning

confidence: 99%

Tumor microenvironment in glioblastoma: Current and emerging concepts

Sharma

Aaroe

Liang

et al. 2023

Neuro-Oncology Advances

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Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex system, which in addition to cancer cells, consists of various resident brain and immune cells as well as cells in transit through the tumor such as marrow derived immune cells. The TME is a dynamic environment which is heavily influenced by alterations in cellular composition, cell-to-cell contact and cellular metabolic products as well as other chemical factors, such as pH and oxygen levels. . Emerging evidence suggests that GBM cells appear to reprogram their the TME, and hijack microenvironmental elements to facilitate rapid proliferation, invasion, migration, and survival thus generating treatment resistance. GBM cells interact with their microenvironment directly through cell-to-cell by interaction mediated by cell-surface molecules, or indirectly through apocrine or paracrine signaling via cytokines, growth factors and extracellular vehicles. The recent discovery of neuron-glioma interfaces and neurotransmitter-based interactions has uncovered novel mechanisms that favor tumor cell survival and growth. Here, we review the known and emerging evidence related to the communication between GBM cells and various components of its TME, discuss models for studying the TME and outline current studies targeting components of the TME for therapeutic purposes.

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“…Therefore, the VN is a critical neuronal communication channel between the CNS and the gut microbiota and is engaged in the bidirectional connection between the gut microbiota and brain [ 136 ]. Multiple types of peripheral nerves in the tumor microenvironment have been shown to influence cancer cell behavior [ 137 ], and the vagus nerve has anti-inflammatory properties mediated through ACh and 7nAChR that have been suggested to slow tumor progression [ 138 , 139 , 140 ]. Consequently, we believe that altering VN function by changing the flora may be a promising strategy for the future treatment of glioma.…”

Section: Impact Of the Local Environmentmentioning

confidence: 99%

Investigational Microbiological Therapy for Glioma

Wang

Liu

Zhang

et al. 2022

Cancers

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Glioma is the most common primary malignancy of the central nervous system (CNS), and 50% of patients present with glioblastoma (GBM), which is the most aggressive type. Currently, the most popular therapies are progressive chemotherapy and treatment with temozolomide (TMZ), but the median survival of glioma patients is still low as a result of the emergence of drug resistance, so we urgently need to find new therapies. A growing number of studies have shown that the diversity, bioactivity, and manipulability of microorganisms make microbial therapy a promising approach for cancer treatment. However, the many studies on the research progress of microorganisms and their derivatives in the development and treatment of glioma are scattered, and nobody has yet provided a comprehensive summary of them. Therefore, in this paper, we review the research progress of microorganisms and their derivatives in the development and treatment of glioma and conclude that it is possible to treat glioma by exogenous microbial therapies and targeting the gut–brain axis. In this article, we discuss the prospects and pressing issues relating to these therapies with the aim of providing new ideas for the treatment of glioma.

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Neural regulations of the tumor microenvironment

Cited by 15 publications

References 113 publications

Expression Profile and Diagnostic Significance of MicroRNAs in Papillary Thyroid Cancer

Expression Profile and Diagnostic Significance of MicroRNAs in Papillary Thyroid Cancer

Tumor microenvironment in glioblastoma: Current and emerging concepts

Investigational Microbiological Therapy for Glioma

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