Neural regulation of endocrine and autonomic stress responses

Ulrich‐Lai, Yvonne M.; Herman, James P.

doi:10.1038/nrn2647

Cited by 2,589 publications

(2,402 citation statements)

References 194 publications

Supporting

Mentioning

2,223

Contrasting

Unclassified

Order By: Relevance

“…These autonomic changes are generated and regulated by evolutionarily conserved brain areas 9, 10, 11. Collectively, these areas are referred to as a “central autonomic network” or, more inclusively, as brain areas for visceral control 12, 13, 14.…”

Section: Introductionmentioning

confidence: 99%

A Brain Phenotype for Stressor‐Evoked Blood Pressure Reactivity

Gianaros

Sheu

Uyar

et al. 2017

JAHA

View full text Add to dashboard Cite

BackgroundIndividuals who exhibit large‐magnitude blood pressure (BP) reactions to acute psychological stressors are at risk for hypertension and premature death by cardiovascular disease. This study tested whether a multivariate pattern of stressor‐evoked brain activity could reliably predict individual differences in BP reactivity, providing novel evidence for a candidate neurophysiological source of stress‐related cardiovascular risk.Methods and ResultsCommunity‐dwelling adults (N=310; 30–51 years; 153 women) underwent functional magnetic resonance imaging with concurrent BP monitoring while completing a standardized battery of stressor tasks. Across individuals, the battery evoked an increase systolic and diastolic BP relative to a nonstressor baseline period (M ∆systolic BP/∆diastolic BP=4.3/1.9 mm Hg [95% confidence interval=3.7–5.0/1.4–2.3 mm Hg]). Using cross‐validation and machine learning approaches, including dimensionality reduction and linear shrinkage models, a multivariate pattern of stressor‐evoked functional magnetic resonance imaging activity was identified in a training subsample (N=206). This multivariate pattern reliably predicted both systolic BP (r=0.32; P<0.005) and diastolic BP (r=0.25; P<0.01) reactivity in an independent subsample used for testing and replication (N=104). Brain areas encompassed by the pattern that were strongly predictive included those implicated in psychological stressor processing and cardiovascular responding through autonomic pathways, including the medial prefrontal cortex, anterior cingulate cortex, and insula.ConclusionsA novel multivariate pattern of stressor‐evoked brain activity may comprise a phenotype that partly accounts for individual differences in BP reactivity, a stress‐related cardiovascular risk factor.

show abstract

Section: Introductionmentioning

confidence: 99%

A Brain Phenotype for Stressor‐Evoked Blood Pressure Reactivity

Gianaros

Sheu

Uyar

et al. 2017

JAHA

View full text Add to dashboard Cite

show abstract

“…Despite the evidence showing that the PFC regulates the activity of the HPA axis [2,10], previous studies had reported conflicting results regarding the role of the medial PFC on basal plasma levels of corticosterone [5,6] probably because they did not distinguish well the prelimbic and infralimbic parts of the medial PFC. As shown, the stimulation of infralimbic cortex by local injections of picrotoxin increased the basal concentrations of corticosterone.…”

Section: Discussionmentioning

confidence: 99%

“…Yet how the PFC exerts this regulation is a matter of debate. Previous studies in rodents suggest that the dorsal (prelimbic) and ventral (infralimbic) parts of the medial PFC exert opposite control on the HPA axis activity and plasma levels of corticosterone in response to stress [2][3][4]. However, most pharmacological and lesion studies are limited to the dorsal part of the medial PFC or do not distinguish between the dorsal and ventral parts [5][6][7][8] and, therefore, the role played by the infralimbic cortex in the regulation of the HPA axis and corticosterone concentrations is still uncertain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Ronzoni

Antón

Mora

et al. 2016

Behavioural Brain Research

View full text Add to dashboard Cite

2 HIGHLIGHTS-Infralimbic stimulation increases basal plasma levels of corticosterone.-Environmental enrichment enhances the effects of infralimbic stimulation.-Infralimbic inhibition reduces stress-induced corticosterone in control animals.-Infralimbic cortex contributes to HPA activation during stress and aversive memory. 3 ABSTRACTThe aim of the present study was to investigate the effects of the stimulation and inhibition of the ventral part of the medial prefrontal cortex (infralimbic cortex) on basal and stress-induced plasma levels of corticosterone and on the acquisition of aversive memory in animals maintained in control and environmental enrichment (EE) conditions. Intracortical microinjections of the GABA A antagonist picrotoxin and agonist muscimol were performed in male Wistar rats to stimulate and inhibit, respectively, the activity of the infralimbic cortex. Injections were performed 60 min before foot shock stress and training in the inhibitory avoidance task. Picrotoxin injections into the infralimbic cortex increased basal plasma levels of corticosterone.These increases were higher in EE rats which suggest that EE enhances the control exerted by infralimbic cortex over the hypothalamus-pituitary-adrenal (HPA) axis and corticosterone release. Muscimol injections into the infralimbic cortex reduced the stress-induced plasma levels of corticosterone and the retention latency 24 h after training in the inhibitory avoidance performance in control and EE animals, respectively. These results further suggest that the infralimbic cortex is required for the activation of the HPA axis during stress and for the acquisition of contextual aversive memories.

show abstract

“…Stress activates neuroendocrine systems and affects the activity of the relative brain area, causing physiological and behavioral responses (Chrousos, 2009; Ulrich‐Lai & Herman, 2009). The most commonly activated neuroendocrine system is the hypothalamus–pituitary–adrenal (HPA) axis, which plays important roles in the response to stressful conditions (Herman et al., 2003; Lupien, McEwen, Gunnar, & Heim, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of Hint1 deficiency on emotional‐like behaviors in mice under chronic immobilization stress

Sun

Liu

et al. 2017

Brain and Behavior

View full text Add to dashboard Cite

BackgroundHistidine triad nucleotide‐binding protein 1 (HINT1) is regarded as a haplo‐insufficient tumor suppressor and is closely associated with diverse neuropsychiatric diseases. Moreover, HINT1 is related to gender‐specific acute behavior changes in schizophrenia and in response to nicotine. Stress has a range of molecular effects in emotional disorders, which can cause a reduction in brain‐derived neurotrophic factor (BDNF) expression in the hippocampus, resulting in hippocampal atrophy and neuronal cell loss.MethodsThis study examined the role of HINT1 deficiency in anxiety‐related and depression‐like behaviors and BDNF expression in the hippocampus under chronic immobilization stress, and investigated whether the sex‐specific and haplo‐insufficient effects exist in emotional‐like behaviors under the same condition.ResultsIn a battery of behavior tests, the results of the control group, not exposed to stress, showed that knockout (KO) and heterozygosity (HT) of Hint1 had anxiolytic‐like and antidepression‐like effects on the male and female mice. However, both male and female Hint1‐KO mice showed elevated anxiety‐related and antidepression‐like behavior under chronic immobilization stress; moreover, both male and female Hint1‐HT mice displayed elevated anxiety‐related behavior and increased depression‐like behavior under chronic immobilization stress. There were no significant differences in general locomotor activity between Hint1‐KO and ‐HT mice and their wild‐type (WT) littermates. Hint1‐KO mice under basal and chronic immobilization stress conditions expressed more BDNF in the hippocampus than did Hint1‐HT and WT mice; overall, there were no significant sex differences in emotional‐like behaviors of Hint1‐KO and ‐HT mice. Additionally, Hint1‐HT mice showed haplo‐insufficient effects on emotional‐like behaviors under basic conditions, rather than under chronic immobilization stress.ConclusionsBoth male and female HINT 1 KO and HT mice had a trend of anxiolytic‐like behavior and antidepression‐like behavior at control group. However, both male and female HINT1 KO mice showed elevated anxiety‐related and antidepression‐like behavior under chronic immobilization stress; moreover, both male and female HINT1 HT mice displayed elevated anxiety‐related behavior and increased depression‐like behavior under chronic immobilization stress.

show abstract

Neural regulation of endocrine and autonomic stress responses

Cited by 2,589 publications

References 194 publications

A Brain Phenotype for Stressor‐Evoked Blood Pressure Reactivity

A Brain Phenotype for Stressor‐Evoked Blood Pressure Reactivity

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Effects of Hint1 deficiency on emotional‐like behaviors in mice under chronic immobilization stress

Contact Info

Product

Resources

About