Neural recruitment associated with anomia treatment in aphasia

Fridriksson, Julius; Morrow-Odom, K. Leigh; Moser, Dana; Fridriksson, Astrid; Baylis, Gordon C.

doi:10.1016/j.neuroimage.2006.04.194

Cited by 99 publications

(83 citation statements)

References 53 publications

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“…Indeed, the two individuals with chronic Broca's aphasia who participated in the study have shown the potential for improvement, but they are currently not receiving any kind of therapy and have not been doing so for a number of years. The improvements we observed for these patients are particularly striking given that those with chronic nonfluent aphasia are said to achieve minimal recovery of speech production (Fridriksson, et al, 2009;Fridriksson, Morrow-Odom, Moser, Fridriksson, & Baylis, 2006). The findings of significant generalisation are especially promising given the brevity of the intervention and suggest that relatively large gains could be made for relatively little time and effort.…”

Section: Discussionmentioning

confidence: 80%

The impact of phonological versus semantic repetition training on generalisation in chronic stroke aphasia reflects differences in dorsal pathway connectivity

Holland

Johns

Woollams

2016

Neuropsychological Rehabilitation

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Section: Discussionmentioning

confidence: 80%

The impact of phonological versus semantic repetition training on generalisation in chronic stroke aphasia reflects differences in dorsal pathway connectivity

Holland

Johns

Woollams

2016

Neuropsychological Rehabilitation

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“…Furthermore, some studies clearly addressing the functional correlates of language rehabilitation, particularly anomia, performed on chronic patients found LH, 10 bilateral, 9,28 or RH 29 activation. It is worth noting that functional MRI (fMRI) studies using different tasks 8,19,20,24,30,31 also found variable activation patterns within the language-related areas (see Thompson and den Ouden 31 for a review), suggesting that the whole network could be consistently activated by different language modalities.…”

Section: Strokementioning

confidence: 99%

“…Most studies focused on the spontaneous recovery of language, [1][2][3][4][5][6][7] but only a few, often single case descriptions, focused on patients submitted to language rehabilitation. [8][9][10][11][12][13] All of these were conducted on chronic patients. The rate of complete spontaneous (ie, without language therapy) aphasia recovery poststroke has been estimated at ≈33% in the first month, 43% after 4 months, and 50% 12 months later.…”

mentioning

confidence: 99%

Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Mattioli

Ambrosi

Mascaro

et al. 2014

Stroke

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A n important issue for language rehabilitation after stroke is the relationship between the effects of therapeutic interventions and the functional changes observed in brain language-related areas. Most studies focused on the spontaneous recovery of language, [1][2][3][4][5][6][7] but only a few, often single case descriptions, focused on patients submitted to language rehabilitation. [8][9][10][11][12][13] All of these were conducted on chronic patients. The rate of complete spontaneous (ie, without language therapy) aphasia recovery poststroke has been estimated at ≈33% in the first month, 43% after 4 months, and 50% 12 months later.14 However, the concept of spontaneous recovery of language may not be appropriate (as human beings are extensively exposed to language). The term language therapy commonly relates to formal interventions provided by speech therapists aimed at improving different language abilities with specific exercises.Evidence supports the use of language rehabilitation in stroke, particularly if intensively administered for short courses in chronic aphasics. 15,16 In a pilot study, Godecke et al 17 found that daily aphasia therapy in early stroke, that is, mean 3 days poststroke (dps), resulted in improved communication outcomes in moderate to severe aphasia. Brain plasticity induced by language training has not been extensively investigated to date. Several studies, conducted in chronic patients, suggested that functional correlates of aphasia recovery could be either the activation of predominantly left hemisphere (LH) language-related areas [18][19][20][21][22] or of the homologous right hemisphere (RH) areas, 2,23-25 but often the authors do not clarify whether patients were formally treated and to what extent, or not. Saur et al 4 suggest that in the postacute stages of recovery (2 weeks poststroke), the LH areas would be reduced in activation, whereas after months Background and Purpose-Early poststroke aphasia rehabilitation effects and their functional MRI (fMRI) correlates were investigated in a pilot, controlled longitudinal study. Methods-Twelve patients with mild/moderate aphasia (8 Broca, 3 anomic, and 1 Wernicke) were randomly assigned to daily language rehabilitation for 2 weeks (starting 2.2 [mean] days poststroke) or no rehabilitation. The Aachen Aphasia Test and fMRI recorded during an auditory comprehension task were performed at 3 time intervals: mean 2.2 (T1), 16.2 (T2), and 190 (T3) days poststroke. Results-Groups did not differ in terms of age, education, aphasia severity, lesions volume, baseline fMRI activations, and in task performance during fMRI across examinations. Rehabilitated patients significantly improved in naming and written language tasks (P<0.05) compared with no rehabilitation group both at T2 and T3. Functional activity at T1 was reduced in language-related cortical areas (right and left inferior frontal gyrus and middle temporal gyrus, right inferior parietal lobule and superior temporal gyrus) in patients compared with controls. T2 and T3 follow-ups r...

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“…35 In addition, Crosson et al 35 raised the possibility that under some circumstances, activation of either the right or left hemisphere may actually interfere with rather than promote recovery of language function. Only a few studies using fMRI to monitor aphasia therapy have been published to date (eg, Wierenga et al, 39 Crosson et al, 40 Meinzer et al, 41 Peck et al, 42 Fridriksson et al, 43 and Vitali et al, 38 ), but unfortunately these studies included only small sample sizes and demonstrated divergent results regarding predominance of left-versus-right hemispheric recruitment as manifestation of posttreatment language plasticity.…”

Section: 22mentioning

confidence: 99%

Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging

Pillai

2009

AJNR Am J Neuroradiol

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SUMMARY: BOLD fMRI has provided new insights into postlesional brain language plasticity by providing a noninvasive in vivo approach to evaluate longitudinal changes in brain cortical activation during performance of language tasks. Specifically, BOLD fMRI has provided the opportunity to investigate not only changes in eloquent language cortex resulting from different types of brain pathology such as brain tumors, stroke, and epilepsy but also changes in eloquent language cortex occurring as a result of actual surgical resection of diseased but, nevertheless, partially functional tissue. In addition to reviewing the literature relating to stroke and epilepsy-related language plasticity as well as the more intriguing phenomenon of postsurgical plasticity in the setting of brain tumors, 2 unusual cases illustrating this latter manifestation of language plasticity are briefly described in this review article.ABBREVIATIONS: BOLD ϭ blood oxygen levelϪdependent; DECS ϭ direct electrical cortical stimulation (intraoperative mapping); fMRI ϭ functional MR imaging; GABA ϭ gamma-aminobutyric acid (neurotransmitter); L ϭ left; LI ϭ laterality index; LIFG ϭ left inferior frontal gyrus; MPRAGE ϭ magnetization-prepared rapid acquisition gradient echo; NV ϭ noun-verb (association); P ϭ phonological (rhyming); PET ϭ positron-emission tomography; R ϭ right; RIFG ϭ right inferior frontal gyrus; S1 ϭ first (preoperative) fMRI scanning session; S2 ϭ second (first postoperative) fMRI scanning session; S3 ϭ third (second postoperative) fMRI scanning session; SPM ϭ Statistical Parametric Mapping; TLE ϭ temporal lobe epilepsy B

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Neural recruitment associated with anomia treatment in aphasia

Cited by 99 publications

References 53 publications

The impact of phonological versus semantic repetition training on generalisation in chronic stroke aphasia reflects differences in dorsal pathway connectivity

The impact of phonological versus semantic repetition training on generalisation in chronic stroke aphasia reflects differences in dorsal pathway connectivity

Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging

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