Neural progenitors, neurons and oligodendrocytes from human umbilical cord blood cells in a serum-free, feeder-free cell culture

Schwann cell-like remyelination following transplantation of human umbilical cord blood (hUCB)-derived mesenchymal stem cells in dogs with acute spinal cord injury

“…It has been shown that hUCB-MSCs can differentiate into neuronal cells in vitro [7,[11][12][13][14]. Moreover, Dasari et al [12] recently reported that many transplanted-hUCB differentiated into oligodendrocytes in rats, and they were able to produce neurotrophins (NT-3 and BDNF) that enhanced myelinogenesis.…”

Cord Blood as a Treatment for Stroke

“…In another study, CD45-cells exposed to fibroblast growth factor (FGF)2 and human epidermal growth factor (hEGF) for 7 days could express β-tubulin III, GFAP, and galactocerebroside (Gal-C) (Bicknese et al 2002). Similarly, lineage negative cells from UCB exposed to FGF4, SCF and flt3-ligand expressed nestin, neurofilament, A2B5 and Sox2 (Chua et al 2009). Brain-derived neurotrophic factor (BDNF) was shown to induce neural-like differentiation of UCB MSCs (Lim et al 2008).…”

1980-2011: Parkinson's Disease and Advance in Stem Cell Research

“…Transplantation of naïve human umbilical vein-derived dopaminergic-like cell in a rat model of PD did not improve motor dysfunction, and required administration of a neurotrophin, nerve growth factor, to induce substantial recovery (Li et al, 2010a). Lineage negative cells from umbilical cord blood efficiently gave rise to neuronal cells and oligodendrocytes in vitro (Chua et al, 2009) while lineage specific (cKit+) amniotic-derived SCs fail to acquire a dopaminergic phenotype after epigenetic stimuli both in vitro and in an animal model of PD (Donaldson et al, 2009). Concordantly, upon neuronal induction bone marrow-derived MSC downregulate markers of other lineages, but fail to differentiate into functional neurons (Thomas et al, 2011).…”