Neural processing of nouns and verbs in spontaneous speech of patients with schizophrenia

Hahn, Wiebke; Domahs, Frank; Straube, Benjamin; Kircher, Tilo; Nagels, Arne

doi:10.1016/j.pscychresns.2021.111395

Cited by 8 publications

(5 citation statements)

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“…Regarding previous evidence for the German language, we considered self-chosen rests of at least 100 ms ( 20 ). We considered every realized word and did not distinguish between word types and tokens ( 22 ).…”

Section: Methodsmentioning

confidence: 99%

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Neural activation during natural speech and rests in patients with schizophrenia and schizophrenia spectrum disorders—an fMRI pilot trial

Hahn,

Tsalouchidou,

Nagels

et al. 2024

Front. Psychiatry

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BackgroundIn schizophrenia patients, spontaneous speech production has been hypothesized as correlating with right hemispheric activation, including the inferior frontal and superior temporal gyri as speech-relevant areas. However, robust evidence for this association is still missing. The aim of the present fMRI study is to examine BOLD signal changes during natural, fluent speech production in patients with schizophrenia in the chronic phase of their disease.MethodsUsing a case–control design, the study included 15 right-handed patients with schizophrenia spectrum disorders as well as 15 healthy controls. The participants described eight pictures from the Thematic Apperception Test for 1 min each, while BOLD signal changes were measured with 3T fMRI. The occurrence of positive and negative formal thought disorders was determined using standardized psychopathological assessments.ResultsWe found significant BOLD signal changes during spontaneous speech production in schizophrenia patients compared to healthy controls, particularly in the right hemispheric network. A post-hoc analysis showed that this right-hemispheric lateralization was mainly driven by activation during experimental rests. Furthermore, the TLI sum value in patients correlated negatively with BOLD signal changes in the right Rolandic operculum.ConclusionsPossible underlying factors for this inverse right-hemispheric lateralization of speech-associated areas are structural changes and transmitter system alterations, as well as a lack of neural downregulation in schizophrenia patients during rest periods due to dysfunctional executive functions. When examining spontaneous speech as the most natural form of language, other influencing factors, such as social cognition or emotional processing, should be considered. Our results indicate that future studies should consider group differences during rest, which might provide additional information typically covered in differential contrasts.

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Section: Methodsmentioning

confidence: 99%

“…Images were realigned to the first image, as uncorrected subject motion can produce type I or type II errors ( 23 , 24 ). The data analysis and correction procedure were conducted analogously to previous studies on spontaneous speech acquisition in fMRI by Kircher ( 9 ) and the brain-imaging working group ( 22 , 25 ).…”

Section: Methodsmentioning

confidence: 99%

Neural activation during natural speech and rests in patients with schizophrenia and schizophrenia spectrum disorders—an fMRI pilot trial

Hahn,

Tsalouchidou,

Nagels

et al. 2024

Front. Psychiatry

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“…These measures can be derived from speech samples across various contexts -social, written texts, media posts, video interviews, and descriptive speech inside a scanner thus obviating the need for a one-to-one clinical interviewing for rating [112,113]. Hypothesis driven studies utilizing such automated measures in conjunction with brain imaging have already shown promising results, providing leads for readouts that can be employed in focal perturbation studies [114][115][116][117]. As these syntactic (e.g.…”

Section: Future Directionsmentioning

confidence: 99%

Language Network Dysfunction and Formal Thought Disorder in Schizophrenia

Palaniyappan

Homan

Alonso-Sánchez

2022

Schizophrenia Bulletin

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Background Pathophysiological inquiries into schizophrenia require a consideration of one of its most defining features: disorganization and impoverishment in verbal behavior. This feature, often captured using the term Formal Thought Disorder (FTD), still remains to be one of the most poorly understood and understudied dimensions of schizophrenia. In particular, the large-scale network level dysfunction that contributes to FTD remains obscure to date. Study Design In this narrative review, we consider the various challenges that need to be addressed for us to move towards mapping FTD (construct) to a brain network level account (circuit). Study Results The construct-to-circuit mapping goal is now becoming more plausible than it ever was, given the parallel advent of brain stimulation and the tools providing objective readouts of human speech. Notwithstanding this, several challenges remain to be overcome before we can decisively map the neural basis of FTD. We highlight the need for phenotype refinement, robust experimental designs, informed analytical choices, and present plausible targets in and beyond the Language Network for brain stimulation studies in FTD. Conclusions Developing a therapeutically beneficial pathophysiological model of FTD is a challenging endeavor, but holds the promise of improving interpersonal communication and reducing social disability in schizophrenia. Addressing the issues raised in this review will be a decisive step in this direction.

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Section: Moving Beyond Rating Scales For Ftdmentioning

confidence: 99%

Language Network Dysfunction and Formal Thought Disorder in schizophrenia

Palaniyappan¹,

Homan²,

Alonso-Sánchez³

2022

Preprint

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BackgroundPathophysiological inquiries into schizophrenia require a consideration of one of its defining features: disorganisation and impoverishment in verbal behaviour. This feature, often captured using the term Formal Thought Disorder, still remains to be one of the most poorly understood and often understudied dimensions of schizophrenia. AimIn this review, we consider the various challenges that need to be addressed for us to move towards mapping FTD (construct) to a brain network level account (circuit). This construct-to-circuit mapping goal is now becoming more plausible than it ever was, given the advent of tools providing objective readouts of human speech. ConclusionsWe suggest that any comprehensive pathophysiological model of schizophrenia must satisfactorily account for the onset and persistence of FTD and address the nature of Language Network dysfunction in this illness. To this end, we consider the need for phenotype refinement, robust experimental designs, informed analytical choices and suggest specific steps that can be taken towards the deciphering the neural mechanisms underwriting FTD, and the translational promise of improved interpersonal communication and reduced social disability.

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Neural processing of nouns and verbs in spontaneous speech of patients with schizophrenia

Cited by 8 publications

References 37 publications

Neural activation during natural speech and rests in patients with schizophrenia and schizophrenia spectrum disorders—an fMRI pilot trial

Neural activation during natural speech and rests in patients with schizophrenia and schizophrenia spectrum disorders—an fMRI pilot trial

Language Network Dysfunction and Formal Thought Disorder in Schizophrenia

Language Network Dysfunction and Formal Thought Disorder in schizophrenia

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