Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway
Angelisa Frasca,
Federica Miramondi,
Erica Butti
et al.
Abstract:The beneficial effects of Neural Precursor Cell (NPC) transplantation in several neurological disorders are well established and they are generally mediated by the secretion of immunomodulatory and neurotrophic molecules. We therefore investigated whether Rett syndrome (RTT), that represents the first cause of severe intellectual disability in girls, might benefit from NPC-based therapy. Using in vitro co-cultures, we demonstrate that, by sensing the pathological context, NPC-secreted factors induce the recove… Show more
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